Method for preparing mangiferin

A mangiferin and aqueous solution technology, applied in the direction of organic chemistry, can solve the problems of operator and environmental damage, many mangiferin impurities, complicated operation process and other problems, and achieve the effects of low production cost, less impurities and simple operation process

Inactive Publication Date: 2011-02-16
广西中医学院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] The existing problems of mangiferin extraction methods are: using organic solvents for extraction may cause harm to operators and the environment; using alkali adjustment process, the operation process is complicated, and the impurity removal process is various, resulting in many mangiferin impurities and low product purity

Method used

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  • Method for preparing mangiferin

Examples

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Embodiment 1

[0027] Will be weighed as 500kg of mango leaves, placed in the extraction pot, add 5000L of 5% sodium hydroxide aqueous solution, boil for 50 minutes, filter the extract for use, then add 5000L of 5% sodium hydroxide solution Sodium hydroxide aqueous solution, boiled for 30 minutes, combined the two filtered extracts, then added hydrochloric acid to it, until the pH of the filtered extract was about 1, let it stand for 2 hours, precipitated impurities, filtered to remove impurities , the filtrate is enriched through a neutral macroporous resin column, and then the mangiferin enriched on the neutral macroporous resin column is eluted with a volume concentration of 70% ethanol aqueous solution 2000L, and the eluate is passed through another A kind of basic macroporous resin column is carried out decolorization treatment, the eluent after decolorization treatment is concentrated, reclaims ethanol wherein, the semi-finished product obtained at this moment already is to contain 75% ...

Embodiment 2

[0029] Put 300kg of almond leaves in the extraction pot, add 3000L of 7% sodium hydroxide aqueous solution, boil for 50 minutes, filter the extract for later use, then add 3000L of 7% sodium hydroxide Aqueous solution, boiled for 30 minutes, combined the two filtered extracts, then added hydrochloric acid to it, until the pH of the filtered extract was about 2, let it stand for 3 hours, precipitated impurities, filtered to remove impurities, and the filtrate was passed through The neutral macroporous resin column is enriched, and then the mangiferin enriched on the neutral macroporous resin column is eluted with a volume concentration of 70% ethanol aqueous solution 1500L, and the eluate is passed through another alkaline The macroporous resin column is subjected to decolorization treatment, the eluent after the decolorization treatment is concentrated, and the ethanol therein is recovered, and the semi-finished product obtained contains 71% mangiferin, and is then dissolved in...

Embodiment 3

[0031]Weigh 400kg of immature fruit of almond leaves, remove the core, place in the extraction pot, add 4000L of 9% sodium hydroxide aqueous solution, boil for 50 minutes, filter the extract for later use, then add 4000L of 9% sodium hydroxide solution It is 9% sodium hydroxide aqueous solution, boil for 30 minutes, combine the extracts filtered out twice, then add hydrochloric acid to it, until the pH of the filtered extract is about 1.5, let it stand for 2 hours, and precipitate impurities , filter to remove impurities, and the filtrate is enriched through a neutral macroporous resin column, and then 2000L of ethanol aqueous solution with a volume concentration of 70% is used to elute the mangiferin enriched on the neutral macroporous resin column, and the eluent Then pass another basic macroporous resin column for decolorization treatment, concentrate the eluate after decolorization treatment, and precipitate crystals to obtain the crude product, then dissolve it to saturati...

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Abstract

The invention discloses a method for preparing mangiferin. The method comprises the following steps of: taking a natural plant as a raw material; and performing the processes of solvent extraction, concentration, separation and purification. The method is characterized in that: the solvent is the aqueous solution of an alkali; and the processes comprise the following steps of: adding the natural plant into the aqueous solution of the alkali in an amount of 8 to 10 times based on the weight part of the natural plant; heating for boiling for 30 to 50 minutes; filtering extracting solution for later use; adding the aqueous solution of the alkali in the amount of 8 to 10 times based on the weight part of the natural plant again; boiling for 10 to 30 minutes; merging the extracting solution obtained from twice filtering; adding the aqueous solution of an acid into the merged solution for precipitating; filtering for removing impurities; and obtaining the mangiferin with the purity of over 95 percent by performing the processes such as enriching, decoloring and refining on the filtrate. The method has a simple process and is suitable for industrial production.

Description

technical field [0001] The invention relates to a method for extracting active ingredients from plants, in particular to a method for extracting mangiferin from natural plants. technical background [0002] Mangiferin (mangiferin, I), also known as mangiferin and anemarrhena, is a carbon glycoside of tetrahydroxypyridine, which belongs to the biphenylpyrazone compound. Mangiferin can be extracted from the leaves, fruits, bark and lilies of mango trees and almond trees in the Anacardiaceae family, Anemarrhena chinensis, Northeast Gentiana, Swert sprouts, Hypericum sampsonii Hance, etc. Its molecular formula is C 19 h 18 o 11 The molecular weight is 422, and the structural formula is as follows: [0003] [0004] Modern pharmacology and clinical studies have proved that mangiferin has many physiological activities and pharmacological effects, such as anti-tumor effect, anti-lipid peroxidation, immune regulation, anti-diabetes, anti-inflammatory, pain relief, anti-virus,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D407/04
Inventor 邓家刚李学坚杜正彩
Owner 广西中医学院
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