Method for detecting salvia heart-soothing capsules

A technology of Danshen Shuxin Capsules and detection methods, which can be used in capsule delivery, measuring devices, and pharmaceutical formulations, and can solve problems such as difficult product quality control

Inactive Publication Date: 2011-03-02
SICHUAN FENGCHUN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The present invention aims at the disadvantages that the existing quality control standards are simple and the product quality is not easy to control. According to the content, characteristics and preparation process of the Danshen medicinal material and its extract in this prescription, a specific and feasible identification and content determination method is researched and customized, so as to effectively Control the quality of Danshen Shuxin Capsules accurately, so as to ensure the clinical efficacy of the preparation

Method used

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  • Method for detecting salvia heart-soothing capsules
  • Method for detecting salvia heart-soothing capsules
  • Method for detecting salvia heart-soothing capsules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0165] Embodiment 1: the detection method of Danshen Shuxin Capsules

[0166] Properties: This product is a capsule, the content is dark brown powder; tasteless, slightly astringent.

[0167] Identification: Take 3g of the content of this product, grind it finely, add 5ml of diethyl ether, shake, stand for 1 hour, filter, evaporate the filtrate to dryness, add 1ml of ethyl acetate to the residue to dissolve, and use it as the test solution; take 1g of Danshen reference drug , grind finely, add 5ml of ether, shake, stand for 1 hour, filter, evaporate the filtrate to dryness, add 1ml of ethyl acetate to the residue to dissolve, and use it as a reference medicinal solution; Take 5 μl of each of the above two solutions, respectively spot on the same silica gel G thin-layer plate, use benzene: ethyl acetate = 19: 1 as the developer, develop, take out, and dry in the air; On the corresponding position of the color spectrum, the spots of the same color are displayed.

[0168] Inspe...

Embodiment 2

[0176] Embodiment 2: the detection method of Danshen Shuxin Capsules

[0177] Properties: This product is a capsule, the content is dark brown powder; tasteless, slightly astringent.

[0178] Identification: Take 3g of the content of this product, grind it finely, add 5ml of diethyl ether, shake, stand for 1 hour, filter, evaporate the filtrate to dryness, add 1ml of ethyl acetate to the residue to dissolve, and use it as the test solution; take 1g of Danshen reference drug , grind finely, add 5ml of ether, shake, stand for 1 hour, filter, evaporate the filtrate to dryness, add 1ml of ethyl acetate to the residue to dissolve, and use it as a reference medicinal solution; Take 5 μl of each of the above two solutions, respectively spot on the same silica gel G thin-layer plate, use benzene: ethyl acetate = 19: 1 as the developer, develop, take out, and dry in the air; On the corresponding position of the color spectrum, the spots of the same color are displayed.

[0179] Inspe...

Embodiment 3

[0183] Embodiment 3: the detection method of Danshen Shuxin capsule

[0184] Properties: This product is a capsule, the content is dark brown powder; tasteless, slightly astringent.

[0185] Identification: Take 3g of the content of this product, grind it finely, add 5ml of diethyl ether, shake, stand for 1 hour, filter, evaporate the filtrate to dryness, add 1ml of ethyl acetate to the residue to dissolve, and use it as the test solution; take 1g of Danshen reference drug , grind finely, add 5ml of ether, shake, stand for 1 hour, filter, evaporate the filtrate to dryness, add 1ml of ethyl acetate to the residue to dissolve, and use it as a reference medicinal solution; Take 5 μl of each of the above two solutions, respectively spot on the same silica gel G thin-layer plate, use benzene: ethyl acetate = 19: 1 as the developer, develop, take out, and dry in the air; On the corresponding position of the color spectrum, the spots of the same color are displayed.

[0186] Inspec...

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Abstract

The invention provides a method for detecting the quality of salvia heart-soothing capsules. The method comprises all or partial items of character detection, identification, inspection and content measurement, wherein the character is capsules which are filled with dark brown powder, and have mild and subastringent taste; the identification means to use salvia contrast medicament as contrast, and a thin-layer chromatography method is adopted for salvia qualitative identification; the inspection needs to accord with regulations related to capsule item in the appendix IL of Chinese pharmacopoeia 2010 (vol.1); and the content measurement is to detect the content of main components tanshinone IIA and salvianolic acid B of the capsules by adopting high-efficiency liquid chromatography method. The quality detecting method has the advantages of strong specificity, high accuracy, good stability, good reproducibility, high reclamation rate, accurate measurement and simpleness and convenience, measures the contents of water-soluble ingredients and ethanol soluble ingredients of the capsules, improves the quality control standard of the salvia heart-soothing capsules, and can effectively control fake salvia heart-soothing capsule production of illegal manufacturers or manufacturers with low level of process control technology so as to ensure the clinical curative effect of the preparation.

Description

technical field [0001] The invention relates to a detection method of Danshen Shuxin Capsule medicine, which belongs to the technical field of quality control of medicines. Background technique [0002] Danshen Shuxin Capsule is a variety recorded in the seventh volume of traditional Chinese medicine preparations in the "Drug Standards of the Ministry of Health". The standard number is WS3-B-1294-93. It has the functions of promoting blood circulation, removing blood stasis, calming the nerves, and is clinically used to treat angina pectoris, chest tightness and palpitations caused by coronary heart disease. However, the existing quality control standard is simple, and the product quality is not easy to control. Only Tanshinone II A reference substance was used as a contrast to the TLC identification of Danshen Shuxin Capsules, but the main components of Tanshinone II A and salvianolic acid B were not identified. The content is determined, and the identification method is n...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61K9/48G01N30/02G01N30/90A61P9/10
Inventor 钟茂团黎勇温国梁古莉邓元平邓元凤
Owner SICHUAN FENGCHUN PHARMA
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