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Linimentum containing mussel polysaccharide, preparation method and application thereof

A technology of polysaccharides and mussels, applied to medical preparations containing active ingredients, anti-inflammatory agents, pharmaceutical formulas, etc., can solve the problems of reduced pain, inconvenience, etc., achieve fragrant smell, fast onset, and good curative effect Effect

Inactive Publication Date: 2011-03-16
ZHEJIANG HUASHENG BIO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Acupuncture or electroacupuncture can produce analgesic effect and significantly reduce the pain sensation, but it requires experienced doctors to operate, which is very inconvenient

Method used

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  • Linimentum containing mussel polysaccharide, preparation method and application thereof
  • Linimentum containing mussel polysaccharide, preparation method and application thereof
  • Linimentum containing mussel polysaccharide, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] A preparation method of a liniment containing mussel polysaccharide, which comprises the following steps in sequence:

[0057] A. Take 40g mussel polysaccharide and set aside;

[0058] B. Take 20g of Panax notoginseng, crush it into coarse powder and impregnate it with 30ml of 75% ethanol as solvent for 24 hours, percolate after soaking, and collect the filtrate at a speed of 3.0ml per minute per kilogram of Panax notoginseng, and collect the filtrate to 200ml reserve;

[0059] C, get propylene glycol 60.0ml, 95% (concentration) ethanol 80.0ml, laurocaprone 10.0ml, ethyl p-hydroxybenzoate 0.05g, 31108 floral essence 0.05ml and polysorbate 80 of 15.0ml, after mixing and dissolving Add the notoginseng liquid obtained in step B, mix again and set aside;

[0060] D. Add the mussel polysaccharide described in step A to 400ml of water to dissolve, then slowly add it to the mixture obtained in step C and mix evenly, add water to 1000.0ml, and then pack it.

Embodiment 2

[0062] A preparation method of a liniment containing mussel polysaccharide, which comprises the following steps in sequence:

[0063] A, take mussel polysaccharide 50g, set aside;

[0064]B. Take 20g of Panax notoginseng, crush it into a coarse powder and soak it with 20ml of 75% ethanol as a solvent for 24 hours, percolate after soaking, and collect the filtrate at a percolation speed of 3.0ml per kilogram of Panax notoginseng, and collect 200ml of the filtrate reserve;

[0065] C, get propylene glycol 60.0ml, 95% (concentration) ethanol 80.0ml, laurocaprolactone 10.0ml, ethyl p-hydroxybenzoate 0.05g, the polysorbate 80 of 31108 floral essence 0.05ml and 15.0ml, after mixing and dissolving Add the notoginseng liquid obtained in step B, mix again and set aside;

[0066] D. Add the mussel polysaccharide in step A to 550ml of water

[0067] After dissolving, slowly add to the mixture obtained in step C and mix well, add water to 1000.0ml, and then pack it.

Embodiment 3

[0069] A preparation method of a liniment containing mussel polysaccharide, which comprises the following steps in sequence:

[0070] A, take mussel polysaccharide 43.7g, set aside;

[0071] B. Take 10g of Panax notoginseng, crush it into a coarse powder and soak it with 18ml of 75% ethanol as a solvent for 24 hours, percolate after soaking, and collect the filtrate at a percolation speed of 2.0ml per kilogram of Panax notoginseng per minute, and collect 100ml of the filtrate reserve;

[0072] C. Take 40.0ml of propylene glycol, 60.0ml of absolute ethanol, 5.0ml of lauroazepam, 0.3g of ethyl p-hydroxybenzoate, 0.05ml of 31108 floral essence and 10.0ml of polysorbate 80, mix and dissolve, then add to step C The prepared Panax notoginseng eluate is mixed again for later use;

[0073] D. After adding the mussel polysaccharide described in step A to 437ml of water to dissolve, slowly add it to the mixture obtained in step C and mix evenly, add water to 1000.0ml, and then pack it...

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Abstract

The invention provides linimentum containing mussel polysaccharide, which comprises the following components in part by weight; 0.01 to 30 parts of mussel polysaccharide, 0.001 to 4 parts of notoginseng root, 0.1 to 10 parts of solvent, 0.01 to 10 parts of transdermal accelerator, 0.01 to 0.5 part of preservative, 0.01 to 10 parts of surfactant, 0.01 to 0.5 part of essence and 50 to 99 parts of purified water. The linimentum has the characteristics of quick effectiveness and good curative effect, and has the excellent effects on symptoms such as local swelling, ecchymosis, pain, dysfunction, local pyrexia and the like which are caused by orthopedics and traumatology. The invention provides a preparation method, which reduces production cost, improves production efficiency and can be used for large-scale production.

Description

technical field [0001] The invention relates to biological preparations, in particular to a liniment containing mussel polysaccharide and its preparation method and application. Background technique [0002] The occurrence of pain is the result of harmful stimulation to the body, which not only affects the work, rest and sleep of the patient, but also increases the mental and psychological burden of the patient. Therefore, effective control and pain relief, methods for relieving or relieving patients' misery are desired by clinicians and patients. [0003] Currently commonly used analgesic drugs to solve pain, commonly used drugs are non-opioids, such as aspirin, ibuprofen, indomethacin, naproxen, etc.; weak opioids, such as codeine, dextropropoxyphene, etc.; strong opioids Such as morphine, diacetylmorphine, mesantong, pethidine, etc.; traditional Chinese medicines such as yanghua, poppy, etc. Although these medicines have good analgesic effects, they also have certain si...

Claims

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Application Information

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IPC IPC(8): A61K36/258A61P17/02A61P29/00A61K31/715
Inventor 陆方明吴恒
Owner ZHEJIANG HUASHENG BIO PHARMA
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