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Method for extracting pseudoginsenoside RT5 and medical application

A technique of imitating ginsenosides and extraction methods, which is applied in the direction of drug combinations, medical preparations containing active ingredients, and pharmaceutical formulas, which can solve problems such as high cost and poor safety, and achieve low cost, simple steps, and high product purity. Effect

Active Publication Date: 2011-04-13
吉林圣亚医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The present invention provides a method for extracting pseudoginsenoside RT5 and its medicinal use, so as to solve the problems of high cost and poor safety in the current extraction and separation method of pseudoginsenoside RT5, and at the same time provide a new effect of pseudoginsenoside RT5 against myocardial ischemia

Method used

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  • Method for extracting pseudoginsenoside RT5 and medical application

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Experimental program
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Effect test

Embodiment 1

[0020] After adding 1000g of total saponins of American ginseng to the macroporous resin, it was eluted with water and 30% ethanol in sequence until no saponin reaction was detected, and then continued to be eluted with 40% ethanol, the eluate was collected, the solvent was recovered, and evaporated to dryness , recrystallized to obtain pseudoginsenoside RT 5 ;

[0021] The macroporous resin is AB-8; the recrystallization reagent is methanol.

Embodiment 2

[0023] After adding 1000g of total saponins of American ginseng to the macroporous resin, elution is carried out with water and 40% ethanol in sequence, until no saponin reaction is present, and then elution is continued with 45% ethanol, the eluate is collected, the solvent is recovered, and evaporated to dryness , recrystallized to obtain pseudoginsenoside RT 5 ;

[0024] Macroporous resin adopts D 101 ; The recrystallization reagent uses ethanol.

Embodiment 3

[0026] After adding 1000 total saponins of American ginseng to the macroporous resin, elution was performed with water and 35% ethanol in sequence until no saponin reaction was detected, and then continued to be eluted with 55% ethanol, the eluate was collected, the solvent was recovered, and evaporated to dryness , recrystallized to obtain pseudoginsenoside RT 5 ;

[0027] Macroporous resin adopts D 4020 ; The recrystallization reagent uses ethyl acetate.

[0028] The present invention will be further described below in conjunction with pharmacodynamic experiments.

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Abstract

The invention relates to a method for extracting pseudoginsenoside RT5 and medical application, which belong to the field of medicaments. The method comprises the following steps of: after total saponins of American ginseng are added into macroporous resin, eluting by using water and 25 to 45 percent ethanol in turn till saponins are not reacted; continuously eluting by using 35 to 55 percent ethanol; collecting eluent; recycling a solvent; drying by distillation; and recrystallizing to obtain the pseudoginsenoside RT5. The pseudoginsenoside RT5 is applied to the preparation of anti-myocardial ischemia medicaments.

Description

technical field [0001] The invention belongs to the field of medicine. Background technique [0002] Panax ginseng is a plant of Araliaceae Panax quinquefolium L. dry roots. Chinese medicine believes that American ginseng has the functions of nourishing qi and nourishing yin, clearing away heat and promoting body fluid. For qi deficiency and yin deficiency, internal heat, cough and asthma with phlegm and blood, asthenia heat, dysphoria, thirst, dry mouth and throat. Modern studies have proved that American ginseng has the functions of anti-fatigue, anti-oxidation, anti-stress, inhibition of platelet aggregation, and reduction of blood coagulation. In addition, it also has the effect of regulating blood sugar for diabetic patients. [0003] The main active ingredient in American ginseng is ginsenoside, which is also the substance with the most significant physiological activity. According to the different structures of saponins, ginsenosides mainly include the following...

Claims

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Application Information

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IPC IPC(8): C07J17/00A61K31/7048A61P9/10
Inventor 李平亚刘金平田旭刘传贵朱继忠李丰
Owner 吉林圣亚医药科技有限公司