Unlock instant, AI-driven research and patent intelligence for your innovation.

Preparation method and application of water-soluble chitosan micro-particles

A technology of water-soluble chitosan and microparticles, which is applied in the fields of application, food preparation, and medical preparations containing active ingredients, etc., and can solve the problems of reducing blood lipid levels and reducing body weight in hyperlipidemic rats

Active Publication Date: 2012-12-12
GUANGDONG PHARMA UNIV
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the studies provided by the patent applications 200910214313.6 and 200910214314.0 are based on hyperlipidemia animal models rather than obesity models. According to common technical knowledge in the field, there are significant differences in physiology and mechanism of action between hyperlipidemia models and obesity models. Although the applicant's above-mentioned technical research results have been successfully applied to the lipid-lowering model by chitosan and water-soluble chitosan particles, chitosan and water-soluble chitosan particles can well reduce hyperlipidemia. The blood lipid level of mice can be applied to the preparation of lipid-lowering drugs or food, but it does not involve whether it can be applied to the preparation of drugs or food with weight-reducing effects

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method and application of water-soluble chitosan micro-particles
  • Preparation method and application of water-soluble chitosan micro-particles
  • Preparation method and application of water-soluble chitosan micro-particles

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] The preparation of embodiment 1 water-soluble chitosan microspheres

[0022] Take by weighing 27.2g water-soluble chitosan (self-made according to existing method or commercially available product, molecular weight is 10~300,000, deacetylation degree is at 85%~99%) is added to 1800ml deionized water mechanical stirrer stirring, is placed to Spray drying after no air bubbles; use the domestic L-117 laboratory spray dryer (Beijing Laiheng Technology Trade Co., Ltd., and similar equipment from other manufacturers can also be used) to prepare micron particles. The preparation process uses a standard 0.7mm nozzle. The air inlet temperature of the drying tower is 160°C, the outlet temperature is 80-85°C, and the hot air flow rate is 90% (about 35m 3 / h), peristaltic pump flow 50% (about 600ml / h), compressed air pressure 120kPa. The preparation method can also refer to the preparation scheme of the applicant in the patent application number 200910214313.6.

[0023] 16.6 g of...

Embodiment 2

[0024] The preparation of embodiment 2 water-soluble chitosan microspheres

[0025] Get 28g of water-soluble chitosan (made by existing methods or commercially available products, molecular weight is 200,000 to 300,000, deacetylation degree is 80% to 85%), add it to 1800ml of deionized water with a mechanical stirrer, place until there are no bubbles Finally, the spray drying method is used to prepare micron particles. The preparation process uses a standard 0.7mm nozzle. The air inlet temperature of the drying tower is 190°C, the outlet temperature is 85-90°C, and the hot air flow rate is 90% (about 35m 3 / h), peristaltic pump flow rate 500ml / h, compressed air pressure 100kPa.

[0026] 17.4 g of water-soluble chitosan microspheres were prepared with a yield of 62.3%. The particle size was measured by a laser particle size analyzer, and the average particle size was 1.58 μm.

Embodiment 3

[0027] The preparation of embodiment 3 water-soluble chitosan microspheres

[0028] Get 27.2g water-soluble chitosan (made by existing methods or commercial products, molecular weight is 400,000-500,000, deacetylation degree 60%-80%), other experimental methods are the same as in Example 1.

[0029] 16.9 g of water-soluble chitosan microspheres were prepared with a yield of 62.1%. The particle size was measured using a laser particle size analyzer, and the average particle size was 1.32 μm.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle sizeaaaaaaaaaa
particle sizeaaaaaaaaaa
particle sizeaaaaaaaaaa
Login to View More

Abstract

The invention discloses a preparation method and application of water-soluble chitosan micro-particles. The water-soluble chitosan micro-particles comprise water-soluble chitosan micro-spheres and water-soluble chitosan nano-particles. The invention provides the application of the water-soluble chitosan micro-particles in preparing weight-loss or lipid lowering medicaments or foods. It is summarized through researches that when applied to the preparation of medicaments or foods for inhibiting appetite or reducing internal fat, the water-soluble chitosan micro-particles have a good effect. Theinvention provides a technical support for better applying water-soluble chitosan to the preparation of the foods or the medicaments for losing weight, realizing effective reduction of food feeding quantity or administration dosage, and obtaining a good weight-losing effect.

Description

technical field [0001] The invention belongs to the technical field of medicine and functional food, and in particular relates to the preparation and application of water-soluble chitosan particles. Background technique [0002] Chitosan (CTS) is obtained by deacetylation of chitin. It is a natural cationic polysaccharide that exists in large quantities in the shells of marine arthropods (shrimp, crab, etc.) and also in lower animal fungi. , insects, and algae cell membranes are rich in resources. Chitosan itself has a positive charge so that it can combine with negatively charged fats and bile acids; chitosan can also combine with neutral fats through hydrophobic bonds to emulsify them. A large number of animal and human experiments have proved that chitosan can significantly reduce blood cholesterol and fat content. [0003] Even though most researchers currently believe that chitosan as a dietary fiber and food additive has almost no toxic side effects on the human body...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K9/14C08J3/12C08L5/08C08J3/24C08K3/32A61K31/722A61P3/04A61P3/06A23L1/09A23L29/30
Inventor 苏政权陶毅张宏亮高冰郭姣胡因铭宛硕
Owner GUANGDONG PHARMA UNIV