Preparation for promoting stability of ceftriaxone sodium granules

Abstract

The invention discloses a preparation for promoting the stability of ceftriaxone sodium granules, which consists of ceftriaxone sodium serving as an active ingredient, a stabilizer and pharmaceutically acceptable soluble auxiliary materials according to a weight ratio of 1: 0.01-1: 15-50, preferably 1: 0.05-0.2: 15-30. The medicament composition prepared by the invention avoids the unstable phenomenon that the chemical reaction of ceftriaxone sodium and monosaccharide or polysaccharide, in particular lactose, which are mixed, is performed to produce brown blocks; and operation is simple and convenient, cost is saved, and the medicament composition is more suitable for mass industrial production.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to a granule of ceftriaxone sodium. Background technique [0002] Ceftriaxone Sodium (Rocephin) is a third-generation cephalosporin antibiotic, used for lower respiratory tract infection, urinary tract, biliary tract infection caused by sensitive pathogenic bacteria, as well as abdominal infection, pelvic infection, skin and soft tissue infection, Bone and joint infection, sepsis, meningitis, etc. and infection prevention during surgery. Similar drugs include ceftriaxone, ceftriaxone, junbizhi, thiatriazine, cephalosporins, ceftaxone, etc. Strong activity against Enterobacteriaceae bacteria. The MIC90 for Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, Citrobacter freundii, indole-positive Proteus, Pruvidenella and Serratia is between 0.12 and 0.25mg / Between L. Enterobacter cloacae, Acinetobacter and Pseudomonas aeruginosa were less sensitive to the d...

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Problems solved by technology

Enterobacter cloacae, Acinetobacter spp and Pseudomonas aeruginosa have poor susceptibility to the drug

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