Application of effective part of Chinese dates and rutin in preparation of antilipemic drug and antilipemic drug

A technology of blood lipid-lowering drugs and effective parts, which is applied in the field of blood-lipid-lowering drugs and can solve problems such as muscle toxicity, side effects, and single action target

Inactive Publication Date: 2011-05-04
HENAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, although Western medicine has a certain effect on regulating blood lipids, it has side effects of varying degrees, and the target is single.
Western medicine statins are currently recognized as the most effective and widely used drugs for lipid-lowering, but they have side effects such as liver and muscle toxicity

Method used

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  • Application of effective part of Chinese dates and rutin in preparation of antilipemic drug and antilipemic drug
  • Application of effective part of Chinese dates and rutin in preparation of antilipemic drug and antilipemic drug
  • Application of effective part of Chinese dates and rutin in preparation of antilipemic drug and antilipemic drug

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Experimental program
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Embodiment 2

[0038] The blood lipid-lowering drug of this embodiment is jointly prepared from the effective part of jujube for lowering blood fat and rutin, wherein the extraction method of the effective part of jujube for lowering blood fat is as follows: remove the core of jujube, and use 90% edible ethanol to press the volume Repeat the cold soaking 3 times at a ratio of 5:1, each time for 7 days, filter, air-dry the filter residue, and boil the air-dried filter residue in water three times for 15 minutes each time, filter the extract, combine the filtrates to concentrate under reduced pressure, dry, and then Jujube polysaccharide DW was obtained by deproteinizing with trichloroacetic acid.

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Abstract

The invention discloses an application of an effective part of Chinese dates and rutin in the preparation of an antilipemic drug and an antilipemic drug. The antilipemic drug is prepared from the antilipemic effective part of Chinese dates and rutin. The combination use of the antilipemic effective parts of Chinese dates, namely polysaccharides of Chinese dates, and rutin can obviously lower the TC (Total Cholesterol) and LDL-C (Low-Density Lipoprotein Cholesterol) levels in the serum of a mouse with hyperlipoidemia, and can obviously increase the HDL-C (High-Density Lipoprotein Cholesterol) level, wherein the dosage of the antilipemic effective parts of Chinese dates and the rutin are respectively reduced by 50%. The polysaccharides of Chinese dates and rutin have good synergistic action on the aspect of TC and LDL-C; the combination use of the polysaccharides of Chinese dates and the rutin can be used for treating IIa and IIb hyperlipoproteinemia with normal or slightly increased TG (Triglyceride) and obviously increased TC and LDL-C.

Description

technical field [0001] The present invention relates to a blood lipid-lowering drug jointly prepared by jujube blood lipid-lowering effective fraction and rutin, and also relates to the application of jujube blood-lipid-lowering effective fraction and rutin in preparing blood lipid-lowering and anti-lipid peroxidation active medicine . Background technique [0002] Jujube is the ripe fruit of the rhamnaceae plant jujube (ziziphus Jujube Mill), which is warm in nature, sweet in taste and non-toxic. It is mainly used to treat evil qi in trusted subordinates, tranquilize the middle, nourish the temper, calm the stomach qi, unblock the nine orifices, help the twelve meridians, replenish less qi, less body fluid, insufficiency in the body, severe shock and heavy limbs, and hundreds of medicines, long-term use to lighten the body and prolong the body. Jujube is delicious and sweet, and its sugar content ranks first in all kinds of fruits. The sugar content of fresh dates is more ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/725A61P3/06A61K31/7048A61K131/00
Inventor 康文艺李晓梅郭曙光
Owner HENAN UNIVERSITY
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