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Method for separating astragalus polysaccharide and astragalin astragaloside by ultrasonic film chromatography

A technology of astragalus polysaccharides and astragalus saponins, which is applied in the field of extraction and separation of active ingredients of medicinal plants, can solve the problems of long process time, low efficiency, and complicated steps, and achieve the effect of controllable separation process, high purity, and simple operation

Inactive Publication Date: 2011-05-04
西安保赛天恒生物技术股份有限公司
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Problems solved by technology

[0003] Aiming at the current problems of extracting and separating astragalus polysaccharides and astragalosides from astragalus, the steps are complicated, the process time is long, and the efficiency is low, the present invention is proposed

Method used

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Effect test

Embodiment 1

[0018] Take 5 kg of Astragalus mongolica medicinal material, pulverize it, extract twice with 12 times the amount of 90% ethanol and water at 70°C and 100°C, respectively, for 1.5 hours each time, and combine all the extracts. The combined filtrate was separated by BCSM-1 ultrasonic membrane separator. When the membrane flux decreased by 5%, the ultrasonic was turned on and adjusted to a weak ultrasonic state. The continuous decrease of the membrane flux could be adjusted to a strong ultrasonic state to collect the filtrate containing small molecules. The liquid is passed and concentrated, and the macromolecular polysaccharides that do not pass through the membrane are circulated and filtered to improve the purity. The circulating concentrate containing macromolecules was collected, precipitated with alcohol, and dried to obtain 431.9 grams of astragalus polysaccharides with a purity of 84.2% (as determined by the phenol-sulfuric acid method).

[0019] The supernatant in the a...

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Abstract

The invention discloses a method for separating astragalus polysaccharide and astragalin astragaloside. The method is characterized by adopting the process combining the separation of an ultrasonic film separator and the separation of reversed-phase preparative column chromatography. The whole technological process is simple, quick and large in processing amount and purifies two active ingredients, namely the astragalus polysaccharide and the astragalin astragaloside, at the same time. The obtained product has high purity. The method has the advantages of simple process, high automation control degree and simple industrial application.

Description

technical field [0001] The invention belongs to a method for extracting and separating two effective components of astragalus astragalus polysaccharide and astragaloside, and belongs to the technical field of extraction and separation of effective components of medicinal plants. Background technique [0002] Astragalus is the dried root of Astragalus mongholicus (Bge.) Hsiao] or Astragalus membranaceus (Fisch.) Bge. of the leguminous plant. Astragalus membranaceus (Fisch.) Bge. Efficacy of purging pus, suppressing sores and promoting muscle growth. Modern pharmacological studies have shown that astragalus polysaccharides and astragalosides are the main active ingredients in medicinal astragalus. Aging and anti-radiation, two-way regulation of blood sugar and other effects, astragaloside also has anti-inflammatory, antihypertensive, analgesic, sedative effects, can promote the normal body's antibody production, and increase the phagocytosis rate of macrophages. At present, t...

Claims

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Application Information

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IPC IPC(8): C08B37/00C07J53/00
Inventor 郭立安赵彦鼎常建华
Owner 西安保赛天恒生物技术股份有限公司
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