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Tulathromycin composition used for treating or preventing pet bacterial diseases and preparation method thereof

A technology of telamycin and its composition, which is applied in the direction of drug combination, antibacterial drugs, skin diseases, etc., can solve the problems of inconvenient administration, reduced breeding income, and high cost of injection, so as to avoid zoonotic diseases, The effect of good curative effect and simple preparation method

Active Publication Date: 2011-05-11
LUOYANG HUIZHONG ANIMAL MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, telamycin preparations are only in the form of injections, and there is a problem of inconvenient administration during large-scale breeding, and the cost of injections is relatively high, resulting in a reduction in breeding income

Method used

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  • Tulathromycin composition used for treating or preventing pet bacterial diseases and preparation method thereof
  • Tulathromycin composition used for treating or preventing pet bacterial diseases and preparation method thereof
  • Tulathromycin composition used for treating or preventing pet bacterial diseases and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 15

[0035] Application of Example 15% W / V Tyramycin Composition in the Preparation of Injection Pharmaceutical Composition for the Treatment of Bacterial Diseases in Pets

[0036] Preparation of 1.5% W / V Tyramycin Injection

[0037] Tyramycin (mass percentage 90% compound of formula I and mass percentage 10% compound of formula II) 5%W / V

[0038] Citric Acid 1%W / V

[0039] Propylene Glycol 30% V / V

[0040] Thioglycerol 0.5%W / V

[0041] Add water for injection to the full volume of 1000ml

[0042] Preparation method: Take 10g of citric acid, add 500ml of water for injection, stir to dissolve, add 50g of gatilamycin, adjust pH to 7.0 with dilute hydrochloric acid, keep warm at 70°C for 30min, stir while keeping warm, place it at room temperature after stirring, add Propylene glycol 300ml, hydrochloric acid to adjust the pH to 5.5, add thioglycerol 5g, add water for injection to 1000ml, mix well, filter through a 0.22μm filter membrane, fill, and sterilize.

[0043] Therapeutic Ef...

Embodiment 210

[0064] Embodiment 210%W / V Tyramycin oral liquid preparation method and its application

[0065] 1.10% W / V Tyramycin Oral Liquid Preparation Method

[0066] Tyramycin phosphate (the phosphate of the compound of formula I of 95% by mass percentage and the phosphate of the compound of formula II of 5% by mass percentage) 10%W / V

[0067] Propylene Glycol 50% V / V

[0068] Sucrose 20%W / V

[0069] Sodium Benzoate 0.1%W / V

[0070] Add purified water to full volume

[0071] Preparation method: Take 300ml of purified water, 100g of gatyramycin phosphate, adjust the pH to 8.0 with 10% aqueous sodium hydroxide solution, keep it warm at 80°C for 20min, stir while keeping warm, place it at room temperature after stirring, add 500ml of propylene glycol, Adjust the pH to 5.5 with hydrochloric acid, add 200g of sucrose to dissolve, add 1g of sodium benzoate, add purified water to 1000ml, mix well, fill, and sterilize.

[0072] 2. Therapeutic effect of Tyramycin oral liquid on canine infec...

Embodiment 3

[0091] The preparation method of embodiment 3 telamycin capsules and its application

[0092] 1. The preparation method of Tyramycin Capsules

[0093] Tyramycin meter Tyramycin tartrate (the tartrate of the compound of formula I of 90% mass percentage and the tartrate of the compound of formula II of 10% mass percentage) 10%W / W

[0094] Dextrin 20%W / W

[0095] Add sucrose to full amount

[0096] Preparation method: Take 100g of Tyramycin tartrate, 200g of dextrin, and 700g of sucrose, mix them evenly, prepare them into granules, dry them, put them into capsules, and get 0.5g / granule.

[0097] 2. Therapeutic effect of Tyramycin Capsules on feline bacterial diarrhea

[0098] Test pets: 24 dogs and 16 cats were all diagnosed with bacterial diarrhea. These samples were collected from pet hospitals from 2009 to 2010.

[0099] Clinical symptoms: acute diarrhea (sometimes diarrhea also contains blood and mucus), vomiting, elevated body temperature, anorexia, depression, abdominal...

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Abstract

The invention discloses an application of a tulathromycin composite in treating or preventing pet bacterial diseases, and also discloses a tulathromycin composite used for treating or preventing pet bacterial diseases and a preparation method thereof. The composite disclosed by the invention has the characteristics of less dosage and good curative effect, and is used for preparing medicament widely used clinically.

Description

technical field [0001] The invention relates to a telamycin composition for treating or preventing pet bacterial diseases and a preparation method thereof, belonging to the field of animal medicine. Background technique [0002] With the improvement of people's living standards, more and more people start to keep pets. Due to the close contact between people and pets, the spread of zoonotic diseases is also becoming more and more serious. Because the zoonotic pathogens carried by pets have not been detected Enough attention, the use of antibiotics to fight against pathogenic bacteria is undoubtedly a favorable weapon, but the accompanying problem of bacterial drug resistance is also becoming more and more serious. According to the survey, there is a common problem of misuse of human antibiotics in pet veterinary clinical treatment, which leads to the emergence of many drug-resistant zoonotic pathogens in animals, which may lead to serious public health problems. [0003] Tu...

Claims

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Application Information

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IPC IPC(8): A61K31/7052A61P31/04A61P1/12A61P11/00A61P1/00A61P13/02A61P27/16A61P13/08A61P17/00
Inventor 刘兴金张许科李兴国
Owner LUOYANG HUIZHONG ANIMAL MEDICINE
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