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Drug combination

A composition and drug technology, applied in the direction of drug combination, active ingredients of heterocyclic compounds, pharmaceutical formulations, etc., can solve problems such as adverse reactions, short action time, slow onset of action, etc. rate reduction effect

Active Publication Date: 2011-05-11
SHANDONG NEWTIME PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to solve the defects of adverse reactions and short action time or slow onset of existing drugs for treating male erectile dysfunction, the present invention provides an ED treatment method with quick onset, long action time and fewer side effects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Clavulanic acid 0.5g

[0033] Sildenafil 50g

[0034] Starch 25g

[0035] Dextrin 35g

[0036] Low-substituted hydroxypropyl cellulose 5g

[0037] 60% ethanol appropriate amount

[0038] Magnesium Stearate 1g

[0039] Preparation process: Weigh clavulanic acid, clavulanic acid, sildenafil, starch, dextrin and low-substituted hydroxypropyl cellulose in the prescribed amount and mix them evenly. Another appropriate amount of 60% ethanol is added to the mixed powder, mixed evenly to make a soft material, granulated through a 16-mesh sieve, and dried below 60°C. After drying, use an 18-mesh sieve to carry out granulation, sieve out the fine powder in the dry granules, mix with the sieved magnesium stearate, and then mix with the dry granules evenly, and press into tablets to obtain the product.

Embodiment 2

[0041] Clavulanate 100g

[0042] Sildenafil 25g

[0043] Microcrystalline Cellulose 180

[0044] Hydroxypropyl Cellulose 15g

[0045] 8% starch slurry appropriate amount

[0046] Magnesium Stearate 1.5g

[0047] Preparation process: Weigh clavulanic acid clavulanic acid, sildenafil, microcrystalline cellulose and hydroxypropyl cellulose and mix uniformly. Take another appropriate amount of 8% starch slurry solution, add it to the mixed powder, mix evenly to make a soft material, pass through a 16-mesh sieve to granulate, and dry below 60°C. After drying, use an 18-mesh sieve to carry out granulation, sieve out the fine powder in the dry granules, mix with the sieved magnesium stearate, and then mix with the dry granules evenly, and press into tablets to obtain the product.

Embodiment 3

[0049] Clavulanate 5g

[0050] Sildenafil 25g

[0051] Starch 25g

[0052] Dextrin 35g

[0053] Low-substituted hydroxypropyl cellulose 5g

[0054] 60% ethanol appropriate amount

[0055] Magnesium Stearate 1g

[0056] Preparation process: Weigh clavulanic acid, clavulanic acid, sildenafil, starch, dextrin and low-substituted hydroxypropyl cellulose in the prescribed amount and mix them evenly. Another appropriate amount of 60% ethanol is added to the mixed powder, mixed evenly to make a soft material, granulated through a 16-mesh sieve, and dried below 60°C. After drying, use an 18-mesh sieve to carry out granulation, sieve out the fine powder in the dry granules, mix with the sieved magnesium stearate, and then mix with the dry granules evenly, and press into tablets to obtain the product.

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Abstract

The invention relates to a drug combination treating male erective dysfunction, in particular to a drug combination containing two foreign medicine active ingredients including Clavulanic acid or salt and phosphodiesterase 5(PDE5) suppressing agents. The combination provided by the invention can overcome the defects of the conventional medicine treating male erective dysfunction such as poor reaction, short action time and slow effect.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating male erectile dysfunction, in particular to a pharmaceutical composition for treating male erectile dysfunction containing two western medicine active ingredients, which belongs to the field of medicine. Background technique [0002] Erectile dysfunction (Erectile Dysfunction, ED) refers to the continuous (more than 3 months) inability of a man to achieve or maintain a penile erection with sufficient hardness to complete satisfactory sexual intercourse under sexual stimulation. According to statistics, 52% of men aged 40 to 70 have different degrees of ED. It is estimated that by 2025, 322 million men worldwide will have ED problems. Erectile dysfunction often involves multiple systems throughout the body, and the etiology is complex, including vascular, neurological, endocrine, psychological and senile factors, so the clinical efficacy is not ideal. [0003] There are three main type...

Claims

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Application Information

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IPC IPC(8): A61K45/00A61K31/424A61K31/519A61K31/53A61K31/4985A61P15/10
Inventor 赵志全强红刚
Owner SHANDONG NEWTIME PHARMA
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