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Preparation method of forsythoside A

A technology of forsythiaside and herbal medicines, which is applied in the preparation of forsythiaside A and the preparation of active monomers of traditional Chinese medicine, which can solve the problems of non-compliance with environmental protection requirements, expensive materials, and high production costs, and achieve low cost, The effect of good reproducibility and convenient production and operation

Inactive Publication Date: 2011-05-18
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage is that the process is complicated, and a large amount of organic solvent is required to be washed during the separation process.
Chinese patents 200610027024.1, 200610027036.4, and 200610027037.9 also use organic solvents in large quantities, and the materials used are expensive and the production cost is high
[0004] The extraction and separation technology of forsythiaside A is now developing in a simple and environmentally friendly modern direction, but most of the processes in the literature and patents are still in the stage of organic reagent extraction and silica gel column separation. Environmental protection requirements, and, in the production operation process, it is also extremely inconvenient

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Take Qingqiao medicinal material, add 5 times of 50% ethanol, reflux extraction twice, each time for 2 hours, filter at 200-300 mesh, combine the extract; concentrate the extract under reduced pressure below 60°C until the crude drug content is 0.1g / ml The concentrated solution was left to cool; the concentrated solution was stirred while adding ethanol until the alcohol content of the supernatant was 25%, and after standing for 8 hours, the supernatant was absorbed and concentrated under reduced pressure below 60°C until the crude drug content was 0.3g / ml of concentrate, let cool. Add dilute hydrochloric acid to the concentrated solution while stirring, adjust the pH value to 1, put the acid solution on the treated AB-8 macroporous adsorption resin column, wash the column with 1 to 2 times the volume of water, discard the washing solution, and the AB-8 column Then wash with 6-10 times volume of 30% ethanol, collect the washing solution; concentrate the washing solutio...

Embodiment 2

[0027] Take Qingqiao medicinal material, add 10 times of 70% ethanol, reflux extraction 3 times, each time for 3 hours, filter at 200-300 mesh, combine the extract; concentrate the extract under reduced pressure below 60°C until the crude drug content is 0.5g / ml The concentrated solution was left to cool; the concentrated solution was stirred while adding ethanol until the alcohol content of the supernatant was 35%, and after standing for 24 hours, the supernatant was absorbed and concentrated under reduced pressure below 60°C until the crude drug content was 0.5g / ml of concentrate, let cool. Stir the concentrated solution and add dilute hydrochloric acid to adjust the pH value to 2. Put the acid solution on the treated AB-8 macroporous adsorption resin column, wash the column with 1 to 2 times the volume of water, discard the washing solution, and use the AB-8 column Then wash with 6-10 times volume of 30% ethanol, collect the washing solution; concentrate the washing soluti...

Embodiment 3

[0030] Take Qingqiao medicinal material, add 8 times of 60% ethanol, reflux extraction twice, each time for 2.5 hours, filter at 200-300 mesh, combine the extract; concentrate the extract under reduced pressure below 60°C until the crude drug content is 0.3g / ml of concentrated solution, let it cool; add ethanol to the concentrated solution while stirring until the supernatant has an alcohol content of 30%. 0.5g / ml concentrate, let cool. Stir the concentrate and add dilute hydrochloric acid to adjust the pH value to 1.5. Put the acid solution on the treated AB-8 macroporous adsorption resin column, wash the column with 1 to 2 times the volume of water, discard the washing solution, and use the AB-8 column Then wash with 6-10 times volume of 30% ethanol, collect the washing solution; concentrate the washing solution below 60°C under reduced pressure until it has no alcohol smell; Wash the column with water, discard the washing solution, and then wash with 4 to 8 times the volu...

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Abstract

The invention discloses a preparation method of forsythoside A, comprising the following steps of: (1) extraction; (2) alcohol precipitation; (3) separation; (4) purification; and (5) enrichment. The preparation method has the advantages of simple and safe process, no pollution, more convenience for production and operation, capability of realizing mass production, conformity to industrial requirement, lower cost, reliable and stable process data, good reproducibility, strong controllability for process, and conformity to GMP (Good Manufacturing Practice) production requirement.

Description

technical field [0001] The invention relates to a method for preparing active monomers of traditional Chinese medicines, in particular to a method for preparing forsythiaside A, which belongs to the field of medicine. Background technique [0002] Forsythia is a deciduous shrub of Forsythiaceae Oleaceae. Its fruit can be used as medicine, which has the functions of clearing away heat and detoxification, dispelling stagnation and reducing swelling, and resisting bacteria and fungi. Forsythiaside A is the main component of forsythia, not only has inhibitory effect on Staphylococcus aureus and other pathogenic bacteria, but also can inhibit phosphodiesterase, fungus and active oxygen, so it is used in natural preservatives and natural The field of antioxidants has a wide range of application prospects. [0003] At present, the extraction and separation methods of forsythiaside A have been reported in various literatures. The method adopted in the prior art directly extracts w...

Claims

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Application Information

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IPC IPC(8): C07H15/18C07H1/08
Inventor 胡晨旭靳元鹏
Owner TIANJIN TASLY PHARMA CO LTD
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