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Preparation method of molecularly imprinted polymer for Cyromazine

A molecular imprinting and cyromazine technology, applied in the field of material chemistry, can solve the problems of low specificity, affecting the sensitivity and quantitative accuracy of the detection method, and the small column cannot be regenerated and used.

Inactive Publication Date: 2011-05-18
SOUTH CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, in terms of sample pretreatment, traditional solid-phase extraction cartridges (such as SCX, C18, MCX, etc.) are used for purification, which lacks selectivity and specificity, thus affecting the sensitivity and quantitative accuracy of the entire detection method. Columns are generally not recyclable

Method used

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  • Preparation method of molecularly imprinted polymer for Cyromazine
  • Preparation method of molecularly imprinted polymer for Cyromazine
  • Preparation method of molecularly imprinted polymer for Cyromazine

Examples

Experimental program
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Embodiment 1

[0028] 1. Preparation of Molecularly Imprinted Prepolymer of Cyromazine

[0029] Weigh 0.166g (1mmol) cyromazine into a test tube, add 5mL methanol / water (10 / 1, v / v), after ultrasonic dissolution, add methacrylic acid 0.690mL (8mmol), ultrasonic 5min, 4 ℃ static Let stand overnight, add ethylene glycol dimethacrylate 5.00mL (10mmol) and azobisisobutyronitrile 30mg, sonicate for 5min, blow nitrogen for 5min, and seal. Polymerize in a water bath at 60°C for 24 hours to obtain block polymer.

[0030] 2. Preparation of Molecularly Imprinted Polymer Particles of Cyromazine

[0031] Grind the massive polymer, pass through a 200-mesh sieve, and repeatedly settle with acetone to remove fine particles, put it into a 15×200mm plugged glass chromatography column, and wash it with 200mL of 10% acetic acid methanol solution to remove the simulated template cyromazine , the flow rate was controlled within 1mL / min, and then washed with 100mL of methanol to remove acetic acid, the particles...

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Abstract

The invention discloses a preparation method of a molecularly imprinted polymer for Cyromazine. In the invention, a molecular imprinting technique is utilized to synthesize a molecularly imprinted polymer with high selectivity and high affinity for Cyromazine. The polymer has high affinity and selectivity for Cyromazine in water and a water solution containing less than 10% of acetonitrile or methanol, and the recovery rate of the polymer is higher than 90%. The molecularly imprinted polymer prepared by the method disclosed by the invention has obvious selectivity for Cyromazine, and has wide application prospects as a sample pretreating material for analyzing Cyromazine in substrates, such as feed, milk and the like.

Description

technical field [0001] The invention relates to the field of material chemistry, in particular to a method for preparing a molecularly imprinted polymer of cyromazine. Background technique [0002] Cyromazine (Cyromazine) belongs to triazine compounds, also known as cyromazine, maggots, chemical name (2-cyclopropylamino-4,6-diamino-1,3,5-triazine), It is a slow-acting insect growth regulator, which is widely added to animal feed to control the growth and development of fly maggots in animal stables and improve the environmental sanitation of livestock and poultry farms. Because many farmers feed food animals with the feed that adds cyromazine for a long time, it will inevitably cause drug residues of cyromazine in animal source food, which will affect people's health. Cyromazine can be metabolized into melamine in animals and in the environment, and long-term enrichment will cause greater harm to humans and the environment. [0003] Establishing a reliable and effective de...

Claims

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Application Information

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IPC IPC(8): C08F220/06C08F222/14C08F4/04C08F2/44C08J9/26B01J20/285B01J20/30B01D15/08
Inventor 贺利民魏艳玲方炳虎郭宏斌张青杰刘敏贺倩倩
Owner SOUTH CHINA AGRI UNIV