Method for preparing glucose raw material for injection from broken rice and preparations
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A technology for glucose and injection, which is applied in the fields of biology and pharmacy, can solve the problems of many impurities, high cost, and loss, and achieve the effect of solving incomplete enzymatic hydrolysis and improving purity
Active Publication Date: 2013-04-24
HUNAN UNIV OF CHINESE MEDICINE
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Problems solved by technology
After liquefaction and saccharification of corn starch, the DE reaches more than 98%, while the liquefaction and saccharification of rice starch is difficult to complete, and there are many impurities, so it is difficult to make glucose for injection
[0003] The source of rice is more extensive. If it can be used as raw material to prepare glucose for injection, the application prospect will be broader. Therefore, there are currently patents for the method of making glucose for injection from rice. The cost of the process is relatively high. If industrial production is carried out, based on the price of glucose for injection in the domestic market, there will be almost no profit or even a loss. Therefore, it is necessary to open up the international market
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Embodiment 1
[0027] Determination of α-BHC, β-BHC, γ-BHC, δ-BHC, pentachloronitrobenzene, PP'-DDE, PP'-DDD OP in broken rice according to the GC method under Appendix VIE of the 2010 edition of "Chinese Pharmacopoeia" '-DDT, PP'-DDT, permethrin, valerate, bromathrin, dichlorvos, methamidophos, acephate, omethoate, diazinon, monocrotophos, dimethoate, Malathion, parathion, methyl parathion, methion, ethion and other 24 kinds of pesticide residue limits are less than 0.05, 0.05, 0.05, 0.05, 0.1, 0.05, 0.05, 0.05, 0.05, 0.05, 0.2, 0.5, 0.1, 0.1, 0.2, 0.05, 0.1, 0.02, 0.05, 8, 0.1, 0.1, 2, 0.2ppm; According to the HPLC method under the appendix VID of the 2010 edition of "Chinese Pharmacopoeia", determine aflatoxin in broken rice B 1 , B 2 , G 1 , G 2 , the limits are less than 25ng·ml -1 According to GB / T5009.9-2003 acid hydrolysis method and GB / T5009.7-2008 reducing sugar direct titration method, the content of starch in broken rice is more than 40%; The protein content is above 3.5%. ...
Embodiment 2
[0040] Take the broken rice that has passed the quality inspection, crush it through a 60-mesh sieve, wash it directly with water 3 times to remove suspended solids, ash, foreign matter, etc., add pure water to soak for 4 hours, the pulping concentration is 25%, and add 0.2% CaCl 2 , the liquefaction temperature is at 95°C, the dosage of α-amylase is 50U·(g rice flour weight) -1 , the pH of the powder slurry is 5.0, the liquefaction time is 45min, and the centrifugal speed is 3000rmp·min -1 Separate the liquefied liquid; the amount of glucoamylase used in the saccharification process is 170U (g rice flour weight) -1 , pullulanase is 0.20ASPU·g -1 , adjust the pH to 5.0 with hydrochloric acid, the temperature is 65°C, and the time is 48h. The first activated carbon impurity removal: the amount of activated carbon is 5.0% of the dry matter, the pH is 3.7, the temperature is 55°C, and the time is 35min. -1 , and then use No. 5 vertical fused glass filter to remove impurities. ...
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Abstract
The invention discloses a method preparing glucose raw material from broken rice for injection and preparations. The broken rice is generated by milling rice and contains bran powder. The method comprises the following steps: performing quality analysis of broken rice; pulverizing acceptable material, pretreating to remove impurities, blending, and liquefying with alpha-amylase; and saccharifying with saccharifying enzyme and pullulanase; removing impurities with activated carbon, performing ion exchange' removing impurities with activated carbon again; and performing nanofiltration and refinement to remove macromolecular compounds, and crystallizing to obtain glucose. From the second impurity removal with activated carbon, the procedures are all conducted under the environment meeting injection preparation requirements. Glucose raw material meeting injection standards is firstly prepared and then blended with liquid under the environment meeting transfusion requirements to be prepared into different types of injections. The broken rice as the raw material is easily-accessible, has low cost, and can be changed into valuables. The method has simple operation process and high product purity, is applicable to industrial production, and has broad application prospects.
Description
technical field [0001] The invention belongs to the technical field of biology and pharmacy, and in particular relates to a production process for making glucose raw materials and preparations for injection from crushed rice. Background technique [0002] Most of the currently used glucose raw materials for injection are made from corn, which is prepared by double-enzymatic hydrolysis of starch, and some are prepared from starch from cassava. Corn contains less protein and has a large starch particle size, while broken rice and rice contain 6.0-10.0% protein, the starch particle size is small, and the starch and protein combine to form a tight network structure that hinders the hydrolysis of starch by α-amylase The disadvantage of incomplete hydrolysis occurs, so the gelatinization temperature is required to be high, above 85°C; while the gelatinization temperature of corn starch is low, and it is easy to liquefy. After liquefaction and saccharification of corn starch, the ...
Claims
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Application Information
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