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Analgesic anti-inflammatory preparation for external application

An anti-inflammatory analgesic and topical technology, applied in anti-inflammatory, non-central analgesic, anesthetic and other directions, can solve the problems of unsatisfactory anti-inflammatory and analgesic effects, and achieve excellent transdermal absorption and ease skin irritation. , excellent permeability and diffusivity

Inactive Publication Date: 2011-05-18
TEIKOKU SEIYAKU KK TEIKOKU SEIYAKU CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0016] However, when considering the actual skin application, the reality of these topical agents is that the anti-inflammatory and analgesic effects of non-steroidal anti-inflammatory analgesics are not ideal, and further improvement is needed.

Method used

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  • Analgesic anti-inflammatory preparation for external application
  • Analgesic anti-inflammatory preparation for external application
  • Analgesic anti-inflammatory preparation for external application

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0055] The preparation method of the external preparation provided by the present invention is not particularly limited. According to the desired dosage form, it can be prepared by fully kneading each component and the required matrix components, etc. for preparing an ordinary external preparation.

[0056] When preparing cataplasms and patches, it can be prepared by spreading the kneaded mixture on release paper, drying the kneaded mixture, bonding it to a soft support, and cutting it into a desired size.

[0057] The external preparations provided by the present invention, for example, when they are ointments, liquid preparations (suspensions, emulsions, lotions, etc.), aerosols, and external powders, are used according to the following usual methods of use: direct application by smearing, etc. Use on affected parts of the skin, or after applying or soaking on a support such as cloth.

[0058] In the case of a cataplasm or a patch, these preparations are directly attached to...

Embodiment 1

[0062] Drug-containing matrices of the formulations shown in Table 1 below were prepared. Specifically, felbinac was dissolved in crotamiton, oxybucaine was dissolved in propylene glycol, and the two were mixed, and then these dissolved substances and other ingredients shown in Table 1 were mixed until uniform to obtain Medicinal base. The drug-containing matrix prepared in this way was treated with 1000g / m 2 Spread on non-woven fabric, lined with polypropylene, then cut into 10×14cm 2 , to obtain an external patch.

[0063] [Table 1]

[0064]

[0065] Unit: parts by weight

Embodiment 2

[0067] Drug-containing matrices of the formulations shown in Table 2 below were prepared. Specifically, indomethacin was dissolved in crotamiton and oxybucaine was dissolved in propylene glycol.

[0068] Then, these solubilized substances were mixed with other ingredients shown in Table 2 until uniform to obtain a drug-containing matrix. The drug-containing matrix prepared in this way was treated with 1000g / m 2 Spread on non-woven fabric, lined with polypropylene, then cut into 10×14cm 2 , to obtain an external patch.

[0069] [Table 2]

[0070]

[0071] Unit: parts by weight

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Abstract

Disclosed is a preparation for external application, which can exhibit the analgesic anti-inflammatory effect of a non-steroidal analgesic anti-inflammatory agent contained therein effectively, can reduce the irritation on an area on the skin to which the preparation is applied, and has an excellent effect on pain associated with an inflammation, such as rheumatoid arthritis, osteoarthritis and lumbago. The preparation for external application is characterized by comprising the non-steroidal analgesic anti-inflammatory agent and oxybuprocaine or a pharmaceutically acceptable salt thereof, wherein the non-steroidal analgesic anti-inflammatory agent is contained in an amount of 0.1 to 10 wt% and oxybuprocaine or the pharmaceutically acceptable salt thereof is contained in an amount of 0.01 to 60 wt%, both relative to the total weight of the preparation. The preparation for external application may take the form of an ointment, a liquid, a suspension, an emulsion, a lotion, an adhesive skin patch, a tape, an aerosol, or a powder for external application.

Description

technical field [0001] The present invention relates to anti-inflammatory and analgesic drugs, in particular, relates to non-steroidal anti-inflammatory and analgesic drugs and oxybucaine as a local anesthetic or pharmaceutically acceptable salts as active ingredients, anti-inflammatory An external preparation with significantly improved analgesic effect. Background technique [0002] So far, people have developed a variety of non-steroidal anti-inflammatory analgesics to replace steroidal anti-inflammatory analgesics with many side effects, and gradually used in clinical practice. [0003] Although these non-steroidal anti-inflammatory analgesics exhibit excellent anti-inflammatory and analgesic effects, their side effects of gastrointestinal dysfunction are strong when administered orally. Therefore, studies have been made on transdermal absorption as an administration route that reduces side effects. Preparations, as external preparations containing non-steroidal anti-in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61K9/06A61K9/08A61K9/10A61K9/12A61K9/14A61K9/70A61K31/165A61K31/192A61K31/245A61K31/381A61K31/405A61K31/5415A61P29/00
CPCA61K9/7023A61K31/192A61K31/381A61K31/165A61K31/405A61K31/5415A61K31/245A61K9/7038A61K45/06A61P23/02A61P25/00A61P29/00A61K2300/00A61K9/06A61K9/70
Inventor 猪尾胜幸川田光裕
Owner TEIKOKU SEIYAKU KK TEIKOKU SEIYAKU CO LTD
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