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Patch and patch preparation

A preparation and patch technology, which is applied in the direction of film/sheet adhesives, adhesives, sheet conveying, etc., can solve problems such as detachment, and achieve sufficient bonding strength, limited movement inhibition, and good adhesion Effect

Active Publication Date: 2015-04-01
NITTO DENKO CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since the patch may be detached from the skin when attached to the skin surface for a long time or to a skin surface that moves greatly, the carboxyl- and sulfo-group-free patch disclosed in Japanese Laid-Open Patent Publication No. 2003-313122 Adhesive bond properties need additional improvement

Method used

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  • Patch and patch preparation
  • Patch and patch preparation
  • Patch and patch preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0072] [Example 1] patch

[0073] (1) First, 70 parts by weight of 2-ethylhexyl acrylate (hereinafter may be referred to as "2-EHA") as monomer (a), 10 parts by weight of N-hydroxyethyl propylene as monomer (b) Amide (hereinafter may be referred to as "HEAA"), 20 parts by weight of N-vinyl-2-pyrrolidone (hereinafter may be referred to as "N-VP") as monomer (c), and 333.3 parts by weight of acetic acid as solvent Ethyl ester was charged into a reaction vessel equipped with a cooling tube, nitrogen guide tube, thermometer, dropping funnel, and stirrer, and then the contents were stirred at room temperature for 1 hour while nitrogen bubbling (100 mL / min). After that, the contents in the reaction vessel were heated, and when the temperature of the contents reached 60° C., 0.2 parts by weight of 2,2′-azobisisobutyronitrile (AIBN) was added as a polymerization initiator. The temperature of the contents was controlled so as to be kept at 60° C., and then polymerization was performed...

Embodiment 2

[0076] [Example 2] patch

[0077] Use 50 parts by weight of 2-ethylhexyl acrylate as monomer (a), 10 parts by weight of N-hydroxyethylacrylamide as monomer (b) and 40 parts by weight of N-vinyl-2-pyrrolidone as Except for the monomer (c), an acrylic copolymer (2-EHA / HEAA / N-VP=50 / 10 / 40) was obtained in the same manner as in Example 1. A composition for forming an adhesive layer was prepared from an acrylic copolymer in the same manner as in Example 1, and then a patch was prepared.

Embodiment 3

[0112] [Example 3] patch preparation

[0113] (1) Pramipexole as a drug was added to the acrylic copolymer solution used in the preparation of the patch of Example 1 in an amount of 5.3 parts by weight relative to 100 parts by weight (solid content) of the acrylic copolymer. Further, isopropyl palmitate (IPP), as an organic liquid component, was added to the mixture in an amount of 72.7 parts by weight relative to 100 parts by weight (solid content) of the acrylic copolymer. Thus, a composition for forming an adhesive layer was prepared. It should be noted that pramipexole has one primary and one secondary amino group in its molecule as shown in formula (III) below.

[0114]

[0115] (2) apply the above-mentioned composition for forming an adhesive layer on the release surface of a release liner made of a polyethylene terephthalate (PET) film having a thickness of 75 μm with an applicator, It was then dried at 80° C. for 5 minutes. After that, a PET film having a thickne...

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Abstract

The patch according to an embodiment of the present invention includes: a support; and a pressure-sensitive adhesive layer on at least one surface of the support, wherein: the pressure-sensitive adhesive layer contains an acrylic copolymer obtained by copolymerizing monomer components containing (a) at least one kind of a monomer of a (meth)acrylic acid alkyl ester and (b) at least one kind of a monomer of an N-hydroxyalkyl (meth) acrylamide; a content of the (meth)acrylic acid alkyl ester monomer (a) with respect to a total amount of the monomer components is 50 wt% to 90 wt% and a content of the N-hydroxyalkyl (meth) acrylamide monomer (b) with respect to the total amount is 1 wt% to 20 wt%; and the monomer components are substantially free of a monomer having a carboxyl group.

Description

[0001] This application claims priority under 35 U.S.C. Chapter 119 to Japanese Patent Application No. 2009-265713 filed on November 20, 2009, which is incorporated herein by reference. technical field [0002] The present invention relates to a patch and a patch preparation for skin protection, transdermal drug administration, and the like. Background technique [0003] Both patches and patch preparations are required to have the following characteristics. The above-mentioned patches and patch preparations are all attached to the skin to achieve purposes such as protecting the skin, fixing various medical devices, and transdermally administering drugs. That is, patches and patch preparations exhibit sufficient adhesiveness when attached to the skin, and can be peeled off and removed without contaminating the skin surface (causing, for example, adhesive residue or stickiness) after its use . In addition, there is a need for both the patch and the patch preparation to be les...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C09J7/02C09J133/08A61K9/70A61K47/32
CPCA61L15/585Y10T428/2887C09J133/26Y10T428/2891A61F13/0246A61K9/7007A61K9/7023A61K9/7038A61K9/7046A61K9/7061C09J133/04C09J7/385C09J2301/302
Inventor 石仓准舟山赖人立川悠关谷纯一笠原刚桥野亮雨山智黑田英利
Owner NITTO DENKO CORP
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