Method for preparing gingko extract with low acid number by ultrasonic extraction

A technology of Ginkgo biloba extract and low acid value is applied in the directions of medical raw materials, drug combinations, antidote and the like derived from Ginkgo biloba, and can solve the problems of high removal cost, inability to meet requirements, and reduced ginkgo flavone and lactone content, etc. To achieve the effect of good deacidification, low production cost and short production cycle

Inactive Publication Date: 2011-06-15
江苏九久环境科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, most of the methods used by domestic manufacturers to remove ginkgophenolic acid use solvent extraction, and one or more times of column chromatography column adsorption. These processes either have poor removal effect and cannot meet the requirements; High cost; or while removing ginkgolic acids, the content of ginkgo flavonoids and lactones is also reduced

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment one: a kind of method for the preparation of low-acid value ginkgo extract by ultrasonic extraction, comprises the following processing steps:

[0022] (1) Ginkgo leaves were dried at 60°C for 24 hours, and pulverized to obtain 100-mesh ginkgo leaf powder;

[0023] (2) the ginkgo leaf powder that step (1) obtains is mixed with the ethanol solution that concentration is 10%, and the ratio of ginkgo powder and ethanol solution is 1g: 5ml, under the condition of 30 ℃, ultrasonic extraction 15 minutes obtains extract, ultrasonic The frequency is 20Hz;

[0024] (3) After the extract obtained in step (2) is concentrated under reduced pressure to remove ethanol, the concentrated solution is obtained, and the vacuum degree of concentrated under reduced pressure is 0.05MPa; in the concentrated solution, precipitant MgCl is added 2 Saturated solution until the pH value of the concentrated solution is 5; the clear solution is obtained after suction filtration;

[0025...

Embodiment 2

[0027] Embodiment two: a kind of method for the preparation of low-acid value ginkgo extract by ultrasonic extraction, comprises the following processing steps:

[0028] (1) Ginkgo leaves were dried at 80°C for 48 hours, and pulverized to obtain 150-mesh ginkgo leaf powder;

[0029] (2) the ginkgo leaf powder that step (1) obtains is mixed with the ethanol solution that concentration is 50%, and the ratio of ginkgo powder and ethanol solution is 1g: 30ml, ultrasonic extraction 3 hours obtains extract under the condition of 70 ℃, ultrasonic The frequency is 28Hz;

[0030] (3) obtain concentrated solution after the extract solution obtained by step (2) is concentrated under reduced pressure and removes ethanol, and the vacuum degree of concentrated under reduced pressure is 0.098MPa; Add precipitant AlCl in concentrated solution 3 Saturated solution until the pH value of the concentrated solution is 10; the supernatant solution is obtained after suction filtration or centrifuga...

Embodiment 3

[0033] Embodiment three: a kind of ultrasonic extraction prepares the method for low-acid value ginkgo extract, comprises the following processing steps:

[0034] (1) Ginkgo leaves were dried at 70°C for 36 hours, and pulverized to obtain 100-mesh ginkgo leaf powder;

[0035] (2) the ginkgo leaf powder that step (1) obtains is mixed with the ethanol solution that concentration is 30%, and the ratio of ginkgo powder and ethanol solution is 1g: 10ml, obtains extraction solution under the condition of 50 ℃ of ultrasonic extraction 2 hours, ultrasonic The frequency is 35Hz;

[0036] (3) the extract obtained in step (2) is concentrated under reduced pressure to remove ethanol to obtain a concentrate, and the vacuum of concentration under reduced pressure is 0.06MPa; in the concentrate, add precipitant CaCl 2 Saturated solution until the pH value of the concentrated solution is 6; the clear solution is obtained after suction filtration or centrifugation;

[0037](4) The supernatan...

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Abstract

The invention relates to a method for preparing a gingko extract with a low acid number by ultrasonic extraction, comprising the following processing steps: (1) baking ginkgo leaves, crushing to obtain ginkgo leaf powder; (2) mixing the ginkgo leaf powder with an ethanol solution, performing ultrasonic extraction to obtain an extracted solution; (3) concentrating the extracted solution by pressure reduction to obtain a concentrated solution; adding a precipitant to the concentrated solution, regulating the pH value of the concentrated solution to 5-10; filtering by suction or centrifuging to obtain a clear solution; (4) enriching the clear solution by macroporous resin columns so that the gingko extract component in the clear solution are enriched on the resin; eluting the macroporous resin columns with an eluent; collecting the solution passing through the columns, namely the liquid eluted by the eluent; and (5) concentrating the solution passing through the columns by pressure reduction, then drying by high-pressure spray to obtain the gingko extract. The method provided by the invention is simple and convenient in operation and has a short production cycle, low production cost and good deacidification effect.

Description

technical field [0001] The invention relates to a method for preparing low acid value ginkgo extract by ultrasonic extraction, which belongs to the technical field of traditional Chinese medicine preparation. Background technique [0002] Ginkgo biloba extract is extracted and separated from the leaves of the Ginkgo biloba plant of the genus Ginkgo biloba. It has been included in the pharmacopoeia in almost all developed western countries. a great contribution. At present, Ginkgo biloba extract and its downstream products have formed an annual sales scale of more than 5 billion US dollars in the international market, and can be called the "king of natural herbal medicines". [0003] The active ingredients in Ginkgo biloba extract are mainly flavonoids and lactones, which can treat cardiovascular and cerebrovascular diseases, senile dementia, brain insufficiency, mental disorders, memory function decline, coronary heart disease, hypertension, It has pharmacological effects ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/16A61P9/00A61P25/28A61P25/18A61P9/10A61P9/12A61P3/06A61P39/06A61P17/00A61K127/00
Inventor 李百健吴超
Owner 江苏九久环境科技有限公司
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