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Medical application of spearmint oil preparation

A technology of spearmint oil and medicine, applied in the field of natural plants, can solve the problems that have not been used for the treatment of diseases, and achieve the effects of enhanced and reduced protein expression and improved airway remodeling.

Inactive Publication Date: 2011-06-15
ZHEJIANG UNIV
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

There are no reports of spearmint oil being used to treat diseases

Method used

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  • Medical application of spearmint oil preparation
  • Medical application of spearmint oil preparation
  • Medical application of spearmint oil preparation

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Abstract

The invention provides a medical application of spearmint oil in preparation of medicaments for treating chronic obstructive pulmonary diseases. The spearmint is taken from labiatae mentha, is obtained by vapor distillation and rectification, and mainly contains 20-60% of limonene and 20-70% of carvone. The pharmacodynamics proves that the spearmint oil provided by the invention lowers the contents of lung tissue TNF (tumor necrosis factor)-alpha and IL-1 beta for lipopolysaccharide, inhibits the over-expression of MMP-9, has an effect on improving models of Klebsiella pneumoniae infection and rat chronic obstructive pulmonary diseases caused by LPS (lipopolysaccharide), has an effect on reducing expression enhancement of lung tissue Nrf2 protein of a COPD (chronic obstructive pulmonary disease) model, and lowers the content of lung tissue IL-8 and the expression of a CCR2 receptor. The spearmint oil provided by the invention is natural and nontoxic and can be used for preparing medicaments for treating chronic obstructive pulmonary diseases.

Description

Medicinal use of a spearmint oil preparation technical field The invention belongs to the use of natural plants, and relates to the application of traditional Chinese medicine spearmint oil in preparing medicines for treating chronic obstructive pulmonary disease. Background technique Spearmint (Menthaspicata (L.) Hudson), also known as spearmint, coriander, etc., English name spearmint, belongs to the Lamiaceae (Lamiaceae) mint genus (Mentha), is a perennial perennial herb. According to the "National Compendium of Chinese Herbal Medicine", spearmint has the functions of dispelling wind, regulating qi, and relieving pain. For colds, coughs, headaches, abdominal distention, dysmenorrhea. Modern research has shown that spearmint decoction, alcohol extract and volatile oil have a certain inhibitory effect on animal pathogens: Salmonella gallis, Escherichia coli, Enterococcus suis and Staphylococcus suis in vitro, especially on Staphylococcus suis. The non-essential oil comp...

Claims

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Application Information

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IPC IPC(8): A61K36/534A61P11/00
Inventor 唐法娣王砚
Owner ZHEJIANG UNIV
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