Ferroferric oxide magnetic nanoparticles and preparation method thereof

Abstract

The invention relates to ferroferric oxide magnetic nanoparticles and a preparation method thereof. The nanoparticles comprises ferroferric oxide nanocores, silicon dioxide network molecules, an amino chain hydrocarbon compound, and a carboxyl chain hydrocarbon compound, wherein the silicon dioxide network molecules form shell layers which cover the ferroferric oxide nanocores, and the amino chain hydrocarbon compound and the carboxyl chain hydrocarbon compound are interlinked on the shell layers. The surfaces of the ferroferric oxide magnetic nanoparticles are modified with amino and carboxyl at the same time, so ferroferric oxide magnetic nanoparticles have an acidic dissociation property and an alkaline dissociation property and can absorb biological macromolecules with negative charges such as DNA in a micro acidic environment and dissociate the biological macromoles easily in a micro alkaline environment, and biological macromolecules can be separated and purified without adding high-salt solution. The preparation method of the nanoparticles is simple, the raw material is relatively cheap, overmuch toxic reagent is not needed, and the promotion and application are convenient.

Description

【Technical field】 [0001] The invention relates to the field of nanometer materials, in particular to ferroferric oxide magnetic nanoparticles and a preparation method thereof. 【Background technique】 [0002] As a special nanomaterial, nanoparticles not only have regular shape, uniform size and large specific surface area, but also their surface properties can be precisely controlled by changing their particle size, shape and surface group properties. Besides that, nanoparticles of different materials have unique physicochemical properties due to their obvious size effect. Therefore, nanoparticles, as a new functional material, have been applied in many fields of biomedicine and have shown good application prospects. With the continuous deepening of the research work on nanoparticles, its application range has gradually penetrated into the field of separation science. Based on its surface properties and unique physical and chemical properties, new nanoparticle materials hav...

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Problems solved by technology

But at the same time, these nanoparticle materials have certain limitations when using electrostatic adsorption to separate biological macromolecules such as nucleic acids.

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