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Low dosage burnet root solid preparation

A solid preparation, low-dose technology, applied in the direction of pill delivery, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problem that the active ingredient of low-dose Burnet eucalyptus preparations can not be evenly distributed and other problems, to achieve the effect of uniform content of active ingredients, stable curative effect, and obvious therapeutic effect

Active Publication Date: 2011-06-22
CHENGDU DIAO PHARMA GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] In summary, the method for preparing low-dose Burnet preparations disclosed in the prior art cannot achieve the technical effect that the active ingredient of the low-dose Burnet preparation——the Burnet is evenly distributed in the preparation

Method used

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  • Low dosage burnet root solid preparation
  • Low dosage burnet root solid preparation
  • Low dosage burnet root solid preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Take Burnet medicinal material 5Kg, sucrose 32Kg, dextrin 47Kg, starch 16Kg, Burnet medicinal material pulverize into fine powder and pass through 80 mesh sieve, if sucrose is agglomerated, powder and sieve likewise, set aside.

[0046] Get 2kg of starch and 4kg of powdered sucrose, and prepare 25kg of adhesive (mass concentration 24%) by boiling pulp method.

[0047] Put the Burnet powder in the trough mixing equipment, conventionally add the remaining 28kg sucrose powder, 47kg dextrin and 14kg starch, and mix for 0.5h; Granulate with a 16-mesh sieve, dry at 70-80°C, and set aside; crush the granules into fine powder, pass through a 80-mesh sieve, mix for 10 minutes, add the remaining 6kg of binder and an appropriate amount of water, make soft materials, and pass through a swing granulator Granulate with a 16-mesh sieve, dry at 70-80°C, granulate, compress into tablets, and coat with film as usual. Each tablet weighs 100mg and contains 5mg of Burnet. After testing, t...

Embodiment 2

[0049] Burnet elm medicinal material 5kg, sucrose 40kg, dextrin 30kg, starch 25kg, Burnet sieve through 120 mesh sieve respectively, if sucrose is agglomerated, powder and sieve in the same way, set aside.

[0050] Get 1kg of sucrose powder and 3kg of starch, and prepare 40kg of binder (mass concentration 10%) by water boiling pulp method, and set aside.

[0051] Put the Burnet powder in the trough mixing equipment, add the remaining auxiliary materials as usual, add 30kg of binder after mixing for 1 hour, make soft material, granulate through a 12-mesh sieve with a swing granulator, and dry at 70-80°C; The obtained granules are crushed into fine powder, passed through a 120-mesh sieve, and mixed for 1 hour; the remaining 10kg of binder is added to moisten, and soft material is made, passed through a 16-mesh sieve by a swinging granulator for granulation, dried at 70-80°C, and granulated; Tablets, coated with sugar as usual. Each tablet weighs 100mg, and each tablet contains ...

Embodiment 3

[0053] Burnet elm medicinal material 1kg, sucrose 27kg, dextrin 59kg, starch 12kg, magnesium stearate 1kg, Burnet sifted through a 200-mesh sieve, if sucrose is agglomerated, also powdered and sieved, set aside.

[0054] Get 1.5kg of sucrose powder and 4.5kg of starch, and prepare 30Kg of adhesive by the method of boiling pulp with water (mass concentration 20%) for subsequent use.

[0055] Put the Burnet powder in the mixing equipment, add the remaining auxiliary materials as usual, mix for 30 minutes, add 11kg of binder, make soft materials, granulate through a 18-mesh sieve with a swing granulator, and dry at 70-80°C; crush the obtained granules into fine powder, pass through a 65 mesh sieve, and mix for 30 minutes; add the remaining 19kg of adhesive to moisten, make soft material, pass through a 18 mesh sieve with a swing granulator to granulate, dry at 70-80°C, and granulate; tablet, 100mg / tablet, each containing Burnet 1mg. After testing, the content uniformity of Burne...

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Abstract

The invention discloses a low dosage burnet root solid preparation. The preparation method of the preparation comprises the following steps of: (1) taking 1-10 parts of burnet root, and pulverizing the burnet root into fine powder; (2) taking 90-99 parts of auxiliary materials, wherein the auxiliary materials contain cane sugar and starch; (3) taking a part of the cane sugar and starch in the step (2) and preparing into an adhesive; (4) mixing the fine powder obtained in the step (1) with the remaining auxiliary materials in the step (2) to obtain a mixture; (5) adding the obtained adhesive to the mixture obtained in the step (4), pelletizing, drying, pulverizing and remixing; and (6) pelletizing, drying and sifting with the remaining adhesive, or water, or the remaining adhesive and water, or an ethanol solution of 5-40% volume concentration, and then preparing into a tablet, a capsule, a pill or a granule. The burnet root in the burnet root preparation of the invention has uniform content and favorable curative effect, is safe, effective and controllable in clinical use and is quickly disintegrated.

Description

[0001] The present invention is a divisional application, the original application number is 201010170742.0, the original application date is April 30, 2010, and the original application name is a preparation method of low-dose Burnet elm solid preparation. technical field [0002] The invention relates to a low-dose burnet solid preparation, which belongs to the field of pharmaceutical preparations. Background technique [0003] Burnet is a perennial herb of the family Rosaceae. As a commonly used traditional Chinese medicine, Burnet has the functions of cooling blood to stop bleeding, clearing heat, detoxifying, reducing swelling and astringing sores. Modern research shows that Burnet has various pharmacological activities such as hemostasis, anti-inflammation, promoting wound healing, antibacterial, etc., and has the effect of treating leukopenia. effect. [0004] The drug standard No. WS-11020 (ZD-1020)-2002 of the Drug and Food Administration of the People's Republic o...

Claims

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Application Information

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IPC IPC(8): A61K36/739A61K9/16A61K9/20A61K9/28A61K9/48A61K47/36A61K47/38A61P7/00A61P7/04A61P17/02
Inventor 汤美健黄沛刘瑜邹文俊王军姬建新姚华
Owner CHENGDU DIAO PHARMA GROUP
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