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Preparation and application of amiodarone molecular imprinting solid-phase extraction column

A molecular imprinting and amiodarone technology, applied in other chemical processes, material testing products, biological testing, etc., can solve problems such as preparations that have not been reported

Inactive Publication Date: 2011-06-22
XINJIANG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no report about the preparation of amiodarone hydrochloride MISPE column at present

Method used

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  • Preparation and application of amiodarone molecular imprinting solid-phase extraction column
  • Preparation and application of amiodarone molecular imprinting solid-phase extraction column
  • Preparation and application of amiodarone molecular imprinting solid-phase extraction column

Examples

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Embodiment Construction

[0010] A) Put the template, functional monomer, cross-linking agent, initiator, and porogen in a 50mL round-bottomed flask at a ratio of 1mmol: 4mmol: 16mmol: 78.5mg, fully dissolve and mix, ultrasonically degas for 5min, pass Nitrogen for 5 minutes, heated in a constant temperature oil bath at 50°C for 24 hours.

[0011] B) Grind the polymer prepared in step A) into powder, sieve the powder, collect the polymer with a particle size of 38-75 μm, and use a Soxhlet extractor to dissolve the powder containing glacial acetic acid-methanol (1:9, V / V) Wash the solution until no amiodarone is detected, continue to wash away acetic acid with methanol, and finally vacuum-dry to constant weight to obtain amiodarone hydrochloride MIP particles.

[0012] The selectivity of amiodarone hydrochloride MIP particles was evaluated by HPLC. The washed MIP particles were dry-packed in a stainless steel chromatographic column (50mm×4.6mm), using methanol:pH=4.0 (75:25, v / v) as the mobile phase, t...

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Abstract

The invention relates to preparation of an adsorbing material and application of the adsorbing material to separation and enrichment of medicaments. The invention relates to an amiodarone hydrochloride molecular imprinting polymer, and preparation and application of an amiodarone hydrochloride molecular imprinting solid-phase extraction column. In the molecular imprinting polymer, amiodarone serves as a template; 4-vinyl pyridine is a functional monomer; ethylene glycol dimethacrylate is a crosslinking agent; and chloroform is a porogenic agent. The molecular imprinting polymer is synthesized by a bulk polymerization method; and molecular imprinting polymer particles are filled in the solid-phase extraction column uniformly so as to obtain the amiodarone hydrochloride molecular imprinting solid-phase extraction column. Amiodarone hydrochloride in biological samples is separated, enriched and purified efficiently. Compared with relative techniques such as the past common solvent extraction method, a C18 solid-phase extraction method and the like, the invention has the advantages that: selectivity is high; and the amiodarone hydrochloride molecular imprinting solid-phase extraction column can be reused, has low cost and is expected to become a necessary method for pretreatment of the amiodarone hydrochloride in the biological samples.

Description

1. Technical field: [0001] The invention relates to the field of drug analysis, in particular to a molecularly imprinted solid-phase extraction (MISPE) column of amiodarone hydrochloride and a preparation method thereof, and is mainly used for highly selective separation and enrichment of amiodarone hydrochloride in biological samples and purification. 2. Background technology: [0002] Amiodarone hydrochloride, referred to as amiodarone, its chemical name is (2-butyl-3-benzofuryl)[4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl] Methyl ketone hydrochloride is a class III antiarrhythmic drug widely used in the treatment and prevention of ventricular and supraventricular arrhythmias. The half-life of amiodarone hydrochloride is very long, and long-term use will accumulate in the body. At the same time, the range of medicinal use is very narrow, and it is easy to produce side effects on the human body. Therefore, it is necessary to detect the concentration of amiodarone hydrochl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/26B01J20/285B01J20/30G01N33/48
Inventor 吐尔洪・买买提刘翠
Owner XINJIANG UNIVERSITY
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