Method for sintering anhydrous calcium sulfate biomedical material

Abstract

The invention relates to a method for sintering an anhydrous calcium sulfate biomedical material, which comprises the following steps of: preparing an anhydrous calcium sulfate material, and adding a sintering aid into the anhydrous calcium sulfate material, so that the sintering aid and the anhydrous calcium sulfate material are mixed fully to form a mixture to be sintered; performing compression molding on the mixture to be sintered; and performing heat treatment on the mixture which is subjected to the compression molding and is to be sintered, so that the mixture to be sintered is sintered to form the anhydrous calcium sulfate biomedical material. The sintering aid contains a first sintering additive and a second sintering additive, wherein the first sintering additive is formed by calcium phosphate, and the second sintering additive is formed by at least one of sodium carbonate, calcium oxide and silicon dioxide. The anhydrous calcium sulfate prepared by the method has excellent sintering capacity and high breaking strength and biologic compatibility, and the degradation rate of the anhydrous calcium sulfate biomedical material implanted into human bodies can be controlled.

Description

technical field [0001] The invention relates to a sintering method of calcium-containing biomedical materials, in particular to a sintering method of anhydrous calcium sulfate biomedical materials. Background technique [0002] In the human body, the bones that support the head, trunk and limbs are mainly composed of bone tissue and bone growth cells. Among them, the main component of bone tissue is calcium phosphate compounds. In real life, some bones may have congenital defects, and human body functions may decline with age, resulting in bone aging and defects. People have been engaged in various jobs for many years, which may also cause mechanical fatigue damage to bone tissue. In addition, when the human body is subject to severe mechanical impact (such as sports injuries or accidents such as falls), it may also cause serious damage to the bones. [0003] In fact, due to factors such as bone aging, mechanical impact or fatigue injury, bone defects (such as cracks or e...

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Problems solved by technology

[0008] As far as calcium sulfate hemihydrate and its derivative products are concerned, since most of the products related to calcium sulfate hemihydrate are products at room temperature (without heat treatment), it is mainly because calcium sulfate hemihydrate does not have sintering behavior after heat treatment, As a result, the final product not only has no formability, but also has relatively weak mechanical strength, which is also the biggest limitation in the application of calcium sulfate hemihydrate

[0009] In addition, if calcium sulfate hemihydrate is directly replaced by anhydrous calcium sulfate material, although anhydrous calcium sulfate biomedical materials can be barely sintered in a lower temperature heat treatment process, it still has low sintering ability and low mechanical strength. Weak, low biocompatibility, and the inability to control the degradation rate of the sintered anhydrous calcium sulfate biomedical material after implantation in the human body, thus lacking commercial application value

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