Medicament packing cork composite film and manufacturing process thereof

Abstract

The invention provides a medicament packing cork composite film and a manufacturing process thereof. The film consists of a surface layer, an intermediate layer and an inner layer, wherein the surface layer and the intermediate layer are mainly made of a thermoplastic elastomer, polyolefin and Teflon nano-powder; and the inner layer is made of a thermoplastic elastomer, polyolefin and a tackifying compatibilizer. The method for processing and forming the composite film for the medicament bottle cork comprises the following steps: metering the raw materials of each layer respectively; mixing and granulating; and manufacturing the film by virtue of a three-layer co-extrusion cast film forming unit or a film blowing unit. A nano-technology is applied to the film, so a medicament cannot be corroded and deteriorated by the cork, the quality guarantee period of the medicament is effectively prolonged; and the elasticity and elongation of the film and a rubber substrate are similar, so the product can be formed easily, the yield is high, the seal performance of the composite film cork is good, the film layer has less possibility of being separated, and application of the film cork and the sealing face of a bottle mouth has no special requirement, therefore, the composite film cork can be produced by utilizing conventional common mould equipment, energy and investment are saved, and the composite film is favorable for popularization and application.

Description

technical field [0001] The invention relates to a medicine packaging material, in particular to a medicine packaging bottle stopper composite diaphragm. Background technique [0002] State Food and Drug Administration Document No. 462 stipulates that from January 1, 2005, all pharmaceutical packaging bottles will stop using natural rubber stoppers and use butyl rubber stoppers or coated rubber stoppers instead. Although the drug packaging has changed to Dingsai rubber stoppers, although the internal cleanliness, chemical stability, air tightness and biological properties of the rubber stoppers are all good, due to the complex rubber formula and the concentration gradient relationship of the added raw materials, it is not related to some molecular activities. After the relatively strong drug is encapsulated, it is absorbed, adsorbed, leached, penetrated, etc. by the drug, which causes compatibility problems between the rubber plug and the drug. The more prominent ones are so...

AI Technical Summary

Problems solved by technology

But the Teflon diaphragm has two major disadvantages: one is that Teflon is a plastic material, and rubber is an elastomer material, and there is a huge difference in elasticity between the two. This will affect the sealing of the end face of the bottle mouth, resulting in leakage of the package and deterioration of the medicine in the bottle

The production of parylene-coated rubber stoppers requires the introduction of expensive special equipment and technology, and currently there is no domestic enterprise producing them