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Clathrate of paeonol and preparation method and quality detection method thereof

A paeonol and clathrate technology, which is applied in the field of clathrates of active ingredients in traditional Chinese medicine, can solve the problems of long time spent, low yield, unfavorable large-scale industrial production, etc.

Active Publication Date: 2012-10-03
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The existing paeonol β-cyclodextrin inclusion technology is heating and stirring method, ultrasonic method, etc., which is not conducive to large-scale industrial production, and the yield is not high, and it takes a long time

Method used

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  • Clathrate of paeonol and preparation method and quality detection method thereof
  • Clathrate of paeonol and preparation method and quality detection method thereof
  • Clathrate of paeonol and preparation method and quality detection method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0141] 1. Preparation of paeonol inclusion compound:

[0142] Take β-cyclodextrin of 6 times the amount of paeonol, add 2 times the amount of water and stir well, heat to 55°C; take paeonol and add 4 times the amount of 85% ethanol, heat to dissolve and pour into β-cyclodextrin Grind in the fine solution for 15 minutes with a colloid mill, discharge the material, place it at room temperature for 14 hours, filter it with suction, and dry it at 40°C to obtain paeonol inclusion compound.

[0143] 2. Detection of paeonol inclusion complex

[0144] (1) Chromatographic conditions: gas chromatograph; capillary chromatographic column with 5% diphenyl-95% dimethylsilane copolymer as stationary phase; inlet temperature: 230°C; detector temperature (FID): 240°C ;Split ratio: 25:1; Temperature program: initial temperature 80°C, keep for 2min, increase to 160°C at 20°C per minute, keep for 6min, measure; carrier gas: nitrogen, flow rate: 1.0ml / min; injection: 2μl ; The number of theoreti...

Embodiment 2

[0150] 1. Preparation of paeonol inclusion compound:

[0151] Take β-cyclodextrin of 10 times the amount of paeonol, add 2.7 times the amount of purified water and stir well, heat to 60°C; take paeonol and add 5 times the amount of 95% ethanol, heat to dissolve and pour into β-cyclodextrin Grind in dextrin solution for 20 minutes with a colloid mill, discharge, stand at room temperature for 24 hours, filter with suction, and dry at 50°C to obtain paeonol inclusion compound. Detection of paeonol inclusion complex

[0152] (1) Chromatographic conditions: gas chromatograph; capillary chromatographic column with 5% diphenyl-95% dimethylsilane copolymer as stationary phase; inlet temperature: 220°C; detector temperature (FID): 230°C ;Split ratio: 20:1; Temperature program: initial temperature 80°C, keep for 2min, increase to 160°C at 20°C per minute, keep for 6min, measure; carrier gas: nitrogen, flow rate: 1.0ml / min; injection: 5μl ; The number of theoretical plates is calculat...

Embodiment 3

[0158] 1. Preparation of paeonol inclusion compound:

[0159] Take β-cyclodextrin with 14 times the amount of paeonol, add 4 times the amount of water and stir well, heat to 70°C; take paeonol and add 7 times the amount of 90% ethanol, heat to dissolve and pour into β-cyclodextrin Grind in the fine solution for 30 minutes with a colloid mill, discharge the material, place it at room temperature for 24 hours, filter it with suction, and dry it at 60°C to obtain paeonol inclusion compound.

[0160] 2. Detection of paeonol inclusion complex

[0161] (1) Chromatographic conditions: gas chromatograph; capillary chromatographic column with 5% diphenyl-95% dimethylsilane copolymer as stationary phase; inlet temperature: 240°C; detector temperature (FID): 250°C ;Split ratio: 25:1; Temperature program: initial temperature 80°C, keep 2min, increase to 160°C at 20°C per minute, keep 6min, measure; carrier gas: nitrogen, flow rate: 1.0ml / min; injection: 10μl ; The number of theoretical ...

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Abstract

The invention relates to a clathrate of paeonol and the preparation method and the quality detection method thereof. The preparation method of the clathrate of paeonol comprises the following steps: adding beta-cyclodextrin into water, stirring, and heating; adding paeonol into ethanol, heating to dissolve, pouring into the beta-cyclodextrin solution, milling with a colloidal mill, discharging, standing at room temperature, performing suction filtering, and drying.

Description

Technical field: [0001] The invention relates to an inclusion compound of an active ingredient of a traditional Chinese medicine, a preparation method and a quality detection method thereof, in particular to an inclusion compound of paeonol, the main component of the Chinese medicine Cortex Moutan, and a preparation method and a quality detection method thereof. technical background: [0002] Paeonol is the main active ingredient of the traditional Chinese medicine Moutan Cortex, which has a wide range of pharmacological effects. Because paeonol has strong volatility and is unstable when exposed to light, heat, and humidity, β-cyclodextrin (cyclodextrin, β- CD) clathrate paeonol to reduce its volatility, increase its stability, and make paeonol crystal solid powder, which is convenient for making various dosage forms and improving curative effect. [0003] "Strait Pharmacy" No. 5, 2005 recorded Zhang Jianjun and Tu Yaosheng's paper "Research on Paeonol Inclusion Process by O...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/12A61K47/48G01N30/02G01N30/06A61K47/69
Inventor 萧伟王振中王正宽窦霞邓彬章晨峰陈凤龙
Owner JIANGSU KANION PHARMA CO LTD