Preparation method of supercritical extractive for Jinxuan hemorrhoid fumigating powder

A technology of supercritical extracts and Jinxuan hemorrhoids, which is applied in the direction of medical preparations containing active ingredients, drug combinations, and pharmaceutical formulas, can solve the problem of extraction and purification technology that has not been reported in relevant materials, does not meet the modernization requirements of the traditional Chinese medicine industry, and is effective The ingredients are easily damaged by heat, etc., to reduce safety hazards, the extraction method is simple, and the effect is not easy to damage

Inactive Publication Date: 2011-07-27
MAYINGLONG PHARMA GROUP
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The preparation method of this production process has disadvantages such as the active ingredients are easily damaged by heat, the yield is low, and the time is long, which does not meet the modernization requirements of the traditional Chinese medicine industry.
[0004] The present invention adopts the common key technology of modernization of traditional Chinese medicine supercritical CO 2 Extraction, to obtain a higher yield of volatile oil effective substances, this extraction and purification technology has no relevant data reports at home and abroad

Method used

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  • Preparation method of supercritical extractive for Jinxuan hemorrhoid fumigating powder
  • Preparation method of supercritical extractive for Jinxuan hemorrhoid fumigating powder
  • Preparation method of supercritical extractive for Jinxuan hemorrhoid fumigating powder

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] A method for preparing supercritical extracts of herbal medicines in Jinxuanzhike Fumigation Powder, the steps are as follows: take honeysuckle, nepeta, and purslane three kinds of medicinal materials, pulverize, sieve, mix, and place in supercritical CO 2 extraction in an extractor to obtain supercritical CO 2 Extracts.

[0030] a. Take honeysuckle, nepeta, and purslane three herbal medicines in proportion, mix them in a ratio of 3:4:3, dry the medicinal materials, pulverize them separately, and pass through 20 or 30 or 40 or 55 or 65 or 74 or 80 or 90 or 100 mesh screen.

[0031] b. Set supercritical CO 2 Extraction in the extraction apparatus, extraction temperature 30 or 35 or 40 or 45 or 50 or 55 or 60 ° C, extraction pressure 15 or 20 or 24 or 28 or 31 or 35 MPa, extraction time 30 or 40 or 55 or 65 or 78 or 85 Or 96 or 105 or 120 or 130 or 140 or 150min. Supercritical CO 2 Extracts. A supercritical extract was obtained. Seal it, weigh it, and store it in a...

experiment example 1

[0040] Below in conjunction with embodiment the method of the present invention will be further described.

[0041] Supercritical CO 2 Extraction process test of extract

[0042] (1) Supercritical CO 2 Extraction process test: using L 9 (3 4 ) Orthogonal test method, take the yield of volatile oil and the content of active ingredient pulegone as investigation index, determine the process parameters of factors such as extraction temperature, extraction pressure, extraction time, and adopt gas chromatography to analyze pulegone in the extract The content of pulegone was determined, and the optimal extraction and preparation process was optimized by taking the yield of volatile oil and the content of pulegone as evaluation indicators. The results are shown in Table 3-Table 6.

[0043] Table 3 Orthogonal test factor level table

[0044]

[0045] Table 4 Supercritical extraction orthogonal test results

[0046]

[0047]

[0048] Table 5 extraction rate analysis of v...

experiment example 2

[0059] Experimental Example 2: Pilot Scale-up Test

[0060] Grind the medicinal materials of honeysuckle, Nepeta, and purslane, pass through a 40-mesh sieve, mix evenly according to the mass ratio of 3:4:3, weigh three portions, each 2.5kg, put them into a 10L extraction kettle, and proceed according to the above-mentioned optimal process parameters Extract, collect the extract, weigh, and determine the yield of the extract and the extraction amount of pulegone. Using the above method, a pilot scale-up test was carried out, and the results are shown in Table 6.

[0061] Table 6 pilot test results

[0062]

[0063] The results show that the process parameters studied in this experiment are feasible, and the process conditions can be transferred to industrial production after further adjustment in the pilot test.

[0064] 1, a kind of preparation method of supercritical extract of herbal medicine in Jinxuanzhike fumigation powder prescription, its steps are:

[0065] a. Ta...

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Abstract

The invention discloses a preparation method of a supercritical extractive of honeysuckle, fineleaf schizonepeta herb, purslane and other vegetable drugs in a Jinxuan hemorrhoid fumigating powder formula, which comprises the following steps of: taking the honeysuckle, the fineleaf schizonepeta herb and the purslane in proportions according to the formula, and then pulverizing and sieving the three medicinal materials; and extracting in a supercritical CO2 extractor, wherein an extracting temperature is 35-55 DEG C, an extraction pressure is 15-35 MPa, and an extraction time is 30-150 min. The yield of the supercritical extractive for the Jinxuan hemorrhoid fumigating powder reaches 2.36%, wherein the content of pulegone as an active constituent reaches 16.78 mg / g. The extractive has the obvious effects of resisting inflammations and easing pains. The extraction process of the extractive has simple process and higher content of the active constituent, reduces production cost, saves energy sources, controls environmental pollution, reduces potential safety hazards in production and meets the requirement of modernization of a Chinese medicine industry.

Description

technical field [0001] The invention relates to the technical field of extraction of effective parts of compound Chinese medicines, and more specifically relates to a preparation method of a supercritical extract of Jinxuanzhike fumigation powder. Background technique [0002] Jinxuan Zhike Fumigation Powder is a Chinese patent medicine variety produced by Wuhan Mayinglong Pharmaceutical Company. The traditional Chinese medicine is prepared from five flavors of Xuanming powder, dry alum, honeysuckle, Nepeta, and purslane, and has the effects of reducing swelling, relieving pain, and expelling wind and dampness; it is clinically used to treat inflammatory external hemorrhoids and anal hemorrhoids caused by hemorrhoid surgery. Inflammation, swelling, pain and other diseases, it has the characteristics of quick onset, good curative effect and convenient use. Therefore, this traditional Chinese medicine variety is quite popular with patients and has a broad market prospect. Ho...

Claims

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Application Information

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IPC IPC(8): A61K36/538A61P9/14A61P29/00A61K33/04A61K33/06
Inventor 刘焱文苏光祥周璐章文颖
Owner MAYINGLONG PHARMA GROUP
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