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Sugar-free embolism eliminating oral liquid and preparation method thereof

A technology of Xiaoshuan oral liquid and sugar-free type, applied in the field of medicine, can solve the problems of difficult filling, high viscosity, easy moisture absorption of sucrose, etc.

Inactive Publication Date: 2011-08-10
HULUNBEIER SONGLU PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Most of the currently available Xiaoshuan oral liquids in the market are sugar-containing, and only one company produces sugar-free ones. The sugar-containing ones all use sucrose as the flavoring agent. Sucrose is easy to absorb moisture and has a high viscosity, which is difficult to fill. The liquid is unstable during storage. Since the human body absorbs sucrose quickly, it has a great impact on blood sugar. It is not suitable for diabetics and obese patients.
Although the present commercially available sugar-free Xiaoshuan oral liquid has changed the above-mentioned defects, it has a bad taste and is difficult to take after examining its mouthfeel and stability, and a large amount of sediments are produced during storage.

Method used

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  • Sugar-free embolism eliminating oral liquid and preparation method thereof
  • Sugar-free embolism eliminating oral liquid and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Take astragalus 550g, angelica, 55g red peony, 55g earthworm, 25g chuanxiong, 25g peach kernel, 25g safflower, 25g safflower, and the above seven flavors, add water and boil three times, the first time is 1.5 hours, and the second and third times are 1 hour respectively. Combine the decoction, filter, and filtrate Concentrate under reduced pressure to a relative density of 1.15-1.25 (50°C), add ethanol to make the alcohol content 60%, refrigerate for 18 hours, take the supernatant, recover the ethanol, concentrate the liquid to 100ml, add 30g xylitol , heat to dissolve, let cool, filter, add 0.8g of sodium benzoate, dilute to 300ml with water, mix well, adjust the pH value to 4.5-6.5 with sodium dihydrogen phosphate-disodium hydrogen phosphate buffer solution, add citric acid and citric acid Appropriate amount of sodium composition, potting and sterilizing to obtain.

Embodiment 2

[0021] Take 600g of astragalus, 60g of angelica, 60g of red peony, 30g of earthworm, 30g of chuanxiong, 30g of peach kernel, 30g of safflower, 30g of safflower, and the above seven flavors, add water and boil three times, the first time is 1.8 hours, and the second and third time are 1.5 hours respectively. Combine the decoction, filter, and filtrate Concentrate under reduced pressure to a relative density of 1.15-1.25 (50°C), add ethanol to make the alcohol content 70%, refrigerate and stand for 20 hours, take the supernatant, recover ethanol, concentrate the liquid to 120ml, add 100g sorbitol, Heat to dissolve, let cool, filter, add 0.9g of benzoic acid, add water to dilute to 300ml, mix well, adjust the pH value to 4.5-6.5 with tartaric acid-sodium tartrate buffer solution, add an appropriate amount of the composition of citric acid and sodium citrate, Potting, sterilization, that is.

Embodiment 3

[0023] Take 650g of astragalus, 65g of angelica, 65g of red peony, 35g of earthworm, 35g of chuanxiong, 35g of peach kernel, 35g of safflower, 35g of safflower, and the above seven flavors. Concentrate under reduced pressure to a relative density of 1.15-1.25 (50°C), add ethanol to make the alcohol content 75%, refrigerate and let stand for 24 hours, take the supernatant, recover the ethanol, concentrate the liquid to 140ml, add mannitol 150g, Heat to dissolve, let cool, filter, add 1.0g of sorbic acid, add water to dilute to 300ml, mix well, adjust the pH value to 4.5-6.5 with sodium hydroxide, add an appropriate amount of the composition of citric acid and sodium citrate, potting, Sterilize, that is.

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Abstract

The invention belongs to the technical field of medicines, and particularly relates to sugar-free embolism eliminating oral liquid for treating hemiplegia, facial paralysis, aphasia, slobbering, atrophy and disability of lower limbs and frequent urination which are caused by stroke. Each 300 milliliters of sugar-free embolism eliminating oral liquid comprises 550 to 650 grams of astragalus, 55 to 65 grams of Chinese angelica, 55 to 65 grams of red paeony root, 25 to 35 grams of earthworm, 25 to 35 grams of szechuan lovage rhizome, 25 to 35 grams of peach seed, 25 to 35 grams of safflower, 30 to 210 grams of sweetener, 0.8 to 1.0 gram of preservative and one or more of pH regulator, a buffering agent and the like. The sugar-free embolism eliminating oral liquid has good mouthfeel and high stability, and is suitable for patients who suffer from the symptoms and particularly are suitable for patients who suffer from diabetes and adiposity.

Description

technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to a sugar-free Xiaoshuan oral liquid for treating hemiplegia caused by apoplexy, crooked mouth and eyes, astringent speech, drooling at the corners of the mouth, fistula of lower limbs, and frequent urination and a preparation method thereof. Background technique [0002] According to the ministerial drug standard WS 3 - Xiaoshuan Oral Liquid prepared by the preparation method given in B-2241-96 is a kind of oral liquid with the functions of invigorating qi, promoting blood circulation and dredging collaterals. It is a sugar-containing oral preparation for hemiplegia, crooked mouth and eyes, astringent speech, drooling in the corners of the mouth, fistula of the lower limbs, and frequent urination caused by stroke. It has been clinically proven to be effective. It is a commonly used drug for clinical and family treatment of the above diseases . The following is the WS...

Claims

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Application Information

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IPC IPC(8): A61K36/73A61K9/00A61P7/02A61P9/10A61K35/64A61K35/62
Inventor 马玉珠孙继春王延辉强振君王昌军
Owner HULUNBEIER SONGLU PHARMA
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