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Silver-loaded biliary tract stent with multiple layers of film coatings and preparation method of silver-loaded biliary tract stent

A multi-layer film and bile duct technology, applied in coating, medical science, surgery, etc., can solve the problems of complicated preparation method, complexity and sterilization performance of biliary stent, and achieve the effect of preventing retrograde infection of biliary tract and prolonging patency period.

Inactive Publication Date: 2011-08-17
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, polymer bactericides have their own complexity. The relative molecular weight and distribution of polymer bactericides, the morphology in solution or coating and the degree of cross-linking of polymers will have a great impact on the bactericidal performance.
[0008] Current reports on biliary stents, such as the Chinese invention patent with publication number CN1586655A, provide a method for preparing a multi-layer drug-composite degradable biliary stent visible under X-rays. However, one of the biliary stents described in this patent document is The preparation method is complicated, and the second is to effectively prevent restenosis and infection from the perspective of utilizing degradation

Method used

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  • Silver-loaded biliary tract stent with multiple layers of film coatings and preparation method of silver-loaded biliary tract stent
  • Silver-loaded biliary tract stent with multiple layers of film coatings and preparation method of silver-loaded biliary tract stent
  • Silver-loaded biliary tract stent with multiple layers of film coatings and preparation method of silver-loaded biliary tract stent

Examples

Experimental program
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Effect test

Embodiment 1

[0045] (1) Preparation of chitosan-loaded nano-silver solution: First, slowly add 0.0849g of silver nitrate into 50ml of chitosan solution (pre-adjusted with HCl to pH = 3.8), and then stir evenly to obtain a chitosan solution of 10mM silver ions. Dissolve 60mg of sodium borohydride in 20ml of triple distilled water, take 5ml and slowly add the above chitosan at a rate of 0.01ml per second. After the dropwise addition, continue to stir for 0.5h, and then process the solution with a microporous membrane to remove large-sized particles and prevent particle agglomeration, and take it immediately. Ultraviolet detection was used to characterize the synthesis results of nanosilver. The prepared chitosan-loaded nano-silver solution was stored in the refrigerator in the dark, and it was detected by ultraviolet light for different days. It was found that the peak position of the nano-silver in the first 8 days basically did not move, and was stable at 396nm, indicating that the prepare...

Embodiment 2

[0048] (1) Preparation of chitosan-loaded nano-silver solution: same as in Example 1, except that the prepared chitosan-loaded nano-silver solution has a concentration of 0.01 mg / ml.

[0049] (2) Preparation of silver-loaded multilayer film-coated biliary stent: immerse the positively charged metal biliary stent in 0.01 mg / ml heparin solution for 30 minutes, wash with triple distilled water three times, and then immerse the metal biliary stent in 0.01 mg / ml chitosan Sugar-loaded nano-silver solution for 30 minutes, washed three times with triple-distilled water, and circulated the above process to obtain 20 layers of silver-loaded multilayer film-coated biliary stents arranged alternately by chitosan nano-silver layers and heparin layers. The total thickness is 100 nm.

Embodiment 3

[0051] (1) Preparation of chitosan-loaded nano-silver solution: same as in Example 1, except that the prepared chitosan-loaded nano-silver solution has a concentration of 10 mg / ml.

[0052] (2) Preparation of silver-loaded multilayer film-coated biliary stent: immerse the positively charged PET polyester biliary stent in 5 mg / ml heparin solution for 1 min after amination treatment with hexamethylenediamine small-molecule amination reagent, Wash with water three times, then immerse the PET polyester biliary stent in 10mg / ml chitosan-loaded nano-silver solution for 1min, wash with three-distilled water three times, repeat the above process, and obtain 18 layers arranged alternately by chitosan nano-silver layer and heparin layer The silver-loaded multilayer film-coated biliary stent, the total thickness of the multilayer film coating is 500nm.

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Abstract

The invention relates to the field of medical materials, in particular to a silver-loaded biliary tract stent with multiple layers of film coatings, which comprises a biliary tract stent body, wherein a multiple layers of film coatings which are alternately arranged according to chitosan nano silver layers and heparin layers are coated on the surface of the biliary tract stent body, the total layer quantity of the multiple layers of film coatings is not less than 4, and the total thickness of the multiple layers of film coatings is between 100 and 2000nm. The invention also provides a preparation method of the silver-loaded biliary tract stent with multiple layers of film coatings, which comprises the steps of: dip-coating the biliary tract stent body in a heparin solution and then dip-coating in a chitosan-loaded nano silver solution, and circularly repeating the steps. The silver-loaded biliary tract stent with multiple layers of film coatings, prepared by utilizing the preparation method disclosed by the invention, has the functions of resisting bacteria, virus and mycete; and due to the adoption of the silver-loaded biliary tract stent, the unobstructed period of the biliary tract stent can be prolonged and the inverse infection of the biliary tract can be prevented.

Description

technical field [0001] The invention relates to the field of medical materials, in particular to a silver-loaded multilayer film-coated biliary stent with antibacterial properties and a preparation method thereof. Background technique [0002] Pathogenic microorganisms such as bacteria and fungi often cause pathological changes in body tissues, seriously threatening human physical and mental health. According to the statistics of the World Health Organization (WHO) in 1998, there were 52 million deaths worldwide in 1995, of which about 33% were caused by bacterial infections, and this proportion is still increasing today. Therefore, the development of medical antibacterial materials and products has received more and more attention. [0003] Medical antibacterial materials can effectively reduce the risk of the body getting sick by blocking, inhibiting or killing pathogenic microorganisms. A good medical antibacterial material should have the following characteristics: 1) ...

Claims

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Application Information

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IPC IPC(8): A61L31/10A61L31/16
Inventor 郑树森杨富春计剑秦运升朱琳吴健
Owner ZHEJIANG UNIV
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