Corn germ oil nano emulsion and preparation method thereof

A technology of corn germ oil and nanoemulsion, which is applied in pharmaceutical formulas, cosmetic preparations, dressing preparations, etc., can solve the problem of corn germ oil penetrating into the deep layer of the skin, achieve slow release of corn germ oil, improve stability, good water solubility

Active Publication Date: 2011-08-31
KARLIE COSMETICS MFG CO LTD +1
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  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are no patent reports on the preparation of corn germ oil nanometers at home and abroad. Therefore, corn germ oil is wrapped and prepared into corn germ oil nanoemulsion through phospholipid encapsulation technology, which not only improves the stability of corn germ oil, but also benefits the production of corn germ oil. Penetrates deep into the skin and exerts its effect

Method used

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  • Corn germ oil nano emulsion and preparation method thereof
  • Corn germ oil nano emulsion and preparation method thereof

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preparation example Construction

[0032] The preparation method of the present invention is as follows:

[0033] 1) Mixing 100 parts by weight of corn germ oil, 65-150 parts by weight of phospholipid and 35-100 parts by weight of nonionic surfactant at a temperature of 25°C to 60°C and stirring conditions to form a homogeneous mixture;

[0034] 2) The above mixed solution is mixed with 85-500 parts by weight of glycerin and 170-650 parts by weight of deionized water at a temperature of 25° C. to 60° C. under stirring conditions to prepare corn germ oil colostrum.

[0035] 3) The corn germ oil primary emulsion obtained in step 2) is processed by mature high-pressure homogenizer technology, the high-pressure homogenization pressure is 500bar to 1500bar, and the number of cycles is 3 to 18 times, and the corn germ oil nanometer can be obtained. lotion.

Embodiment 1

[0038] 1) Weigh 65g of soybean lecithin (phosphatidylcholine content ≈ 72%) and stir with 100g of corn germ oil and 50g of polyoxyethylene 40 hydrogenated castor oil at 60°C and 200rpm to form a homogeneous mixture;

[0039] 2) Mix the above mixed solution with 200g glycerin and 450g deionized water at 60°C and 1800rpm, and continue to stir until a uniform emulsion is formed.

[0040] 3) Finally, the transparent corn germ oil nanoemulsion was obtained by subjecting the above emulsion to a high-pressure homogenizer for 5 cycles under the pressure of 800 bar, and the average particle size was 82nm as measured by a laser scattering instrument.

Embodiment 2

[0042] 1) Weigh 100g egg yolk phospholipid (phosphatidylcholine content ≈ 72%) and stir with 100g corn germ oil and 35g polyoxyethylene 20 sorbitan monooleate at 55°C and 400rpm to form a uniform mixture;

[0043] 2) Mix the above mixture with 500g glycerin and 650g deionized water at 50°C and 1800rpm, and continue to stir until a uniform emulsion is formed;

[0044] 3) Finally, the above-mentioned emulsion was processed through a high-pressure homogenizer for 4 cycles under a pressure of 1000 bar to obtain a transparent corn germ oil nanoemulsion, and the average particle size was 68nm as measured by a laser scattering instrument.

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Abstract

The invention relates to a corn germ oil nano emulsion and a preparation method thereof, in particular to a corn germ oil nano emulsion and a preparation method thereof. The corn germ oil nano emulsion is characterized by consisting of the following components in part by weight: 100 parts of corn germ oil, 65 to 150 parts of phospholipids, 35 to 100 parts of stabilizer, 85 to 500 parts of glycerol and 170 to 650 parts of deionized water. The preparation method comprises the following steps of: mixing the components to form corn germ oil early emulsion; and performing high-pressure homogenizing circulation on the corn germ oil early emulsion by using a high-pressure homogenizer to prepare the corn germ oil nano emulsion. The nano corn germ oil concentrated emulsion has the average particle size of less than 100nm and is transparent or semi-transparent; the stability of the corn germ oil is improved, and the compatibility of the corn germ oil and water-soluble materials is improved; and the corn germ oil nano emulsion has high penetration and absorption performance and moisture retention performance and can be used for preparing cosmetics.

Description

technical field [0001] The invention belongs to the technical field of cosmetics, and in particular relates to a corn germ oil nanoemulsion and a preparation method thereof. Background technique [0002] Corn germ oil is rich in nutrients and has high nutritional value. More than oleic acid, linoleic acid and linolenic acid are unsaturated fatty acids in its fatty acid composition. It does not contain cholesterol and is rich in vitamins. It has the ability to prevent atherosclerosis and Anti-aging effect, is increasingly becoming an ideal healthy and nutritious food. Long-term consumption of corn germ oil can improve the function of human brain cells, enhance memory, alleviate the aging of the human body mechanism and the formation of senile plaques, prevent muscle atrophy, enhance physical vitality, prevent cerebral thrombosis and myocardial infarction, and control blood cholesterol. In recent years, it has been used more and more in cosmetics. Corn germ oil is mixed into...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/97A61K8/92A61Q19/00
Inventor 段明星周华锋徐之伟严泽民
Owner KARLIE COSMETICS MFG CO LTD
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