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Oil-in-water type spearmint oil nano emulsion and method for preparing same

A technology of spearmint oil and oil-in-water type, which is applied in the field of medicine, can solve the problems of affecting the curative effect of spearmint oil, easy volatilization of spearmint oil, and low bioavailability, so as to improve bioavailability, improve sensory quality, The effect of improving solubility

Inactive Publication Date: 2011-08-31
NORTHWEST A & F UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But spearmint oil is volatile, and loss is huge in processing; And spearmint oil is fat-soluble medicine, and water solubility is poor, and bioavailability is low, has influenced the exertion of the curative effect of spearmint oil

Method used

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  • Oil-in-water type spearmint oil nano emulsion and method for preparing same
  • Oil-in-water type spearmint oil nano emulsion and method for preparing same
  • Oil-in-water type spearmint oil nano emulsion and method for preparing same

Examples

Experimental program
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Effect test

Embodiment 1

[0059] Embodiment 1 oil-in-water type spearmint oil nanoemulsion

[0060] Mix 40.00g of RH-40 with 11.00g of absolute ethanol, then add 3.00g of vitamin E, 3.00g of ethyl acetate and mix well, then add 8.00g of spearmint oil and mix well, slowly add 35.00g of distilled water at room temperature, and Add distilled water and stir until a clear, transparent, colorless or yellow liquid with low viscosity and good fluidity is formed.

Embodiment 2

[0061] Embodiment 2 oil-in-water type spearmint oil nanoemulsion

[0062] Tween-80 50.00g, absolute ethanol 10.00g, ethyl acetate 15.00g, spearmint oil 0.01g, distilled water 25.00g.

Embodiment 3

[0063] Embodiment 3 oil-in-water type spearmint oil nanoemulsion

[0064] RH-40 48.00g, absolute ethanol 12.00g, ethyl acetate 3.00g, spearmint oil 12.00g, distilled water 25.00g.

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Abstract

The invention discloses oil-in-water type spearmint oil nano emulsion. The nano emulsion is 1 to 100nm in grain size and consists of the following raw materials in percentage by weight: 20.00 to 50.00 percent of surfactant, 3.00 to 24.00 percent of cosurfactant, 2.00 to 15.00 percent of oil phase, 0.01 to 12.00 percent of spearmint oil and the balance of distilled water. The nano emulsion is yellow or colorless, clarified and transparent liquid, has high stability, and can improve the medical stability of spearmint oil during processing, improve the solubility and the bioavailability of spearmint oil, prolong the in vivo metabolism time of spearmint oil and enjoy a wide market prospect in medical field.

Description

technical field [0001] The invention belongs to the field of medicine and relates to a new dosage form of spearmint oil, in particular to a stable and clear oil-in-water type spearmint oil nanoemulsion and a preparation method thereof. Background technique [0002] Spearmint oil is a spice oil extracted from the stems and leaves of spearmint. The main components are celeriac oil terpene ketones, lemon hydrocarbons, cress oil hydrocarbons, etc. It is used in food, cosmetics and pharmaceutical industries. Spearmint oil has mild antibacterial ability, can control the growth of bacteria on the skin surface, and is suitable for acne treatment; it is also very beneficial to the digestive system, especially the stomach, liver and small intestine, it has anti-spasmodic effect, can calm the smooth muscles of the stomach and intestines, It can treat colic, diarrhea, indigestion, vomiting and nausea; in addition, because of the cool smell of spearmint oil, it can relieve headaches or s...

Claims

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Application Information

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IPC IPC(8): A61K36/534A61K9/107A61K47/34A61K47/44A61P1/02A61P1/08A61P1/12A61P1/14A61P17/00A61P17/10A61P25/00A61P37/04A61K47/26
Inventor 欧阳五庆尚朋朋李雅
Owner NORTHWEST A & F UNIV
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