Allogeneic bone cement for bone defect repair and preparation method thereof

Abstract

The invention discloses an allogeneic bone cement for bone defect repair, which is composed of a component A and a component B, wherein the component A is prepared by mixing allogeneic muscle tendon collagen fibers and allogeneic bone particles according to a ratio of 1:(2-8); the component B is a colorless, transparent and viscous sodium hyaluronate solution of which the pH value is 6-7 and the concentration is 5-20mg / ml; and the component A and the component B are mixed according to a ratio of 1g:(1.5-3.5)ml. The allogeneic bone cement has good biological activity and biodegradability, has no kidney toxicity, has fine osteoinduction and osteophony effects, and is convenient to use, thereby being widely used in the field of bone defect repair.

Description

Technical field [0001] The invention relates to the technical field of medical bone injury repairing composite materials, in particular to an allogeneic bone paste for repairing bone defects and a preparation method thereof. Background technique [0002] At present, there are many kinds of medical repair composite materials clinically used for bone injury, such as polymer materials, metal materials, various bioactive materials and ceramics. However, although these composite materials for restoration are widely used, their biocompatibility and biodegradability are not ideal due to the long-term placement of these composite materials in the human body, and this shortcoming has not been well resolved. In recent years, bone cement, as a new type of bone graft material, has attracted extensive attention from those skilled in the art due to its good biocompatibility and biodegradability. Bone cement is easy to operate in clinical operations, and can be arbitrarily molded and fill...

AI Technical Summary

Problems solved by technology

However, although these composite materials for restoration are widely used, their biocompatibility and biodegradability are not ideal due to the long-term placement of these composite materials in the human body, and this shortcoming has not been well resolved.

And in the existing bone paste preparation method, mostly adopt glycerin or gelatin as curing agent, because glycerol itself has nephrotoxicity, the application amount of the bone paste of prior art can not exceed 2ml / kg in human body, and use gelatin bone paste The strength of bone cement is poor, and it is difficult to achieve the strength required for bone damage repair, so the practical application of bone cement is limited.