Nanometer pore hydroxyl calcium phosphate/aquogel materials

A calcium hydroxyphosphate and hydrogel technology, applied in the field of biomedicine, can solve problems such as ignoring the role of water-soluble proteins

Active Publication Date: 2013-06-05
CHANGZHOU KANGWEI BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional theoretical concepts ignore the role of water-soluble proteins

Method used

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  • Nanometer pore hydroxyl calcium phosphate/aquogel materials
  • Nanometer pore hydroxyl calcium phosphate/aquogel materials
  • Nanometer pore hydroxyl calcium phosphate/aquogel materials

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0074] The preparation method of the nanoporous calcium hydroxyphosphate / hydrogel material provided by the invention comprises the following steps:

[0075] (1) Prepare a hydrophilic polymer aqueous solution with a mass concentration of 1%, prepare a glutaraldehyde aqueous solution with a mass concentration of 3%, and prepare a polypeptide aqueous solution with a concentration of 10 μg / ml,

[0076] The above-mentioned hydrophilic polymer is collagen; the above-mentioned polypeptide is osteopontin (osteopontin, OPN) contained in bones; the hydrophilic polymer material is added with a mass percentage of 0.0001% of a small molecular compound that promotes the proliferation of osteoblasts .

[0077] (2) Preparation of hydrogel substrate: Mix the three aqueous solutions prepared in step (1) according to the volume ratio of 1:1:1, stir at room temperature for 0.5 minutes, and then place the mixture on the carrier, The hydrogel substrate was prepared by phase separation technique, a...

Embodiment 2

[0082] The preparation method of the nanoporous calcium hydroxyphosphate / hydrogel material provided by the invention comprises the following steps:

[0083] (1) Prepare a hydrophilic polymer aqueous solution with a mass concentration of 5%, prepare a glutaraldehyde aqueous solution with a mass concentration of 8%, and prepare a polypeptide aqueous solution with a concentration of 300 μg / ml,

[0084] The above-mentioned hydrophilic polymer is gelatin; the above-mentioned polypeptide is phosphophoryn or its fragments contained in teeth; the above-mentioned hydrophilic polymer material is added with a mass percentage of 5% of a small molecular compound that promotes the proliferation of osteoblasts.

[0085] (2) Preparation of hydrogel substrate: Mix the three aqueous solutions prepared in step (1) according to the volume ratio of 1:1:1, stir at room temperature for 10 minutes, and then place the mixture on the carrier, The hydrogel substrate was prepared by phase separation tech...

Embodiment 3

[0090] The preparation method of the nanoporous calcium hydroxyphosphate / hydrogel material provided by the invention comprises the following steps:

[0091] (1) Prepare a hydrophilic polymer aqueous solution with a mass concentration of 3%, prepare a glutaraldehyde aqueous solution with a mass concentration of 6%, and prepare a polypeptide aqueous solution with a concentration of 150 μg / ml,

[0092] The above-mentioned hydrophilic macromolecule is a composition of collagen and gelatin, and the weight ratio of collagen and gelatin is 1:3; the above-mentioned polypeptide is a polypeptide rich in aspartic acid, wherein the sum of said aspartic acid accounts for The weight percentage is 10%; the hydrophilic polymer material is added with a mass percentage of 2.5% of a small molecular compound that promotes the proliferation of osteoblasts.

[0093] (2) Preparation of hydrogel substrate: Mix the three aqueous solutions prepared in step (1) according to the volume ratio of 1:1:1, st...

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Abstract

The invention belongs to the field of biological medicines, and particularly relates to hydroxyl calcium phosphate / aquogel materials which are used as repair and implanting materials for bones or teeth. In order to solve the problems that high bonding interfaces are not formed between tooth implants and dental bones and the like during tooth or bone repair in the prior art, the invention providesnanometer pore hydroxyl calcium phosphate / aquogel materials, which are characterized in that an aquogel surface is modified by polypeptides, and hydroxyl calcium phosphate is deposited on aquogel by the bionic mineralization process. The nanometer pore hydroxyl calcium phosphate / aquogel materials are materials which are highly close to or consistent with materials of human bodies in aspects of macroscopic forms and microstructures and are used for orthopedics and dentistry, are high in biocompatibility, and can be used as repair materials, filling materials and biological support materials for the teeth or the bones.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to a calcium hydroxyphosphate / hydrogel material used as bone or tooth repair and implant material. Background technique [0002] According to relevant statistics, the incidence rate of caries in the population of our country is 37%, with an average of 2.47 caries per person. There is a great demand for filling materials for repairing caries, and the estimated annual demand is about 1 ton. However, none of the currently used dental filling materials can promote rapid restoration of tooth tissue. [0003] For lost carious teeth, an artificial tooth root is usually installed. Artificial tooth root, also known as dental implant, is a device that is surgically implanted into the jawbone of the missing tooth of the human body and repaired on its upper part after healing. Dental implants can be roughly divided into five types according to their materials, namely (1) metal and alloy...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/52A61L27/32A61L27/22A23L1/29A61K6/033A23L33/00A61K6/838
Inventor 戴立军
Owner CHANGZHOU KANGWEI BIOTECH
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