Preparation method of notopterygium root spray of nine ingredients

A technology of spray and notopterygium, which is applied in the field of preparation of Jiuwei notopterygium spray, can solve the problems that the extraction method is not scientific and rigorous, the active ingredients are easily degraded by heat, and the active ingredients of volatile oil are lost, so as to improve the bad smell and increase the bioavailability , the effect of flexible administration

Inactive Publication Date: 2011-10-05
JIANGXI POZIN PHARMA
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Problems solved by technology

However, the preparation methods of Jiuwei notopterygium preparations disclosed in the Pharmacopoeia and the above invention patents are all prepared by immersion, percolation extraction, steam distillation to extract the volatile oil in the medicinal materials, decoction to extract water-soluble components, and concentration. The process is relatively rough, and the extraction method is not scientific and rigorous, resulting in low extraction rate and serious waste of Chinese medicinal materials. Some active ingredients are easily degrade

Method used

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Examples

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Example Embodiment

[0021] Example 1.

[0022] Prescription composition: Qianghuo 3kg, windproof 3kg, atractylodes 3kg, asarum 1kg, Ligusticum chuanxiong 2kg, Angelica dahurica 2kg, scutellaria baicalensis 2kg, licorice 2kg, rehmannia 2kg, poloxamer 0.6kg, peppermint flavor 0.5kg, sodium benzoate 0.3kg. A total of 500 bottles were made.

[0023] Use the following steps to prepare: the above nine Chinese medicinal materials, Qianghuo, Fangfeng, Cangzhu, Asarum, Chuanxiong, Angelica dahurica use supercritical CO 2 The volatile oil is extracted by fluid extraction technology (extraction pressure is 30MPa, extraction temperature is 60℃, extraction 3h), the extracted medicinal residue, scutellaria baicalensis, licorice, and rehmannia glutinosa are added to 10 times the amount of water, and ultrasonic extraction is carried out twice, each 0.5h (Ultrasonic power 100W, ultrasonic frequency 28kHz, temperature 25℃), filter, concentrate the filtrate to concentrate the filtrate to a relative density of 1.00~1.3 (...

Example Embodiment

[0024] Example 2.

[0025] Prescription composition: Qianghuo 3kg, Fangfeng 3kg, Atractylodes 3kg, Asarum 1kg, Ligusticum chuanxiong 2kg, Angelica dahurica 2kg, Scutellaria baicalensis Georgi 2kg, Licorice 2kg, Rehmannia glutinosa 2kg, polyethylene glycol stearate 0.8kg, rose essence 0.6kg, sodium benzoate and 0.2kg of peppermint oil each. A total of 500 bottles were made.

[0026] Use the following steps to prepare: the above nine Chinese medicinal materials, Qianghuo, Fangfeng, Cangzhu, Asarum, Chuanxiong, Angelica dahurica use supercritical CO 2 The volatile oil is extracted by fluid extraction technology (extraction pressure is 20MPa, extraction temperature is 35°C, extraction 5h). The extracted medicinal residue is added to 10 times the amount of water together with the rest of scutellaria, licorice and rehmannia, and ultrasonically extracted twice, each time 0.25h (ultrasonic power 120W, ultrasonic frequency 60kHz, temperature 20℃), filter and concentrate the filtrate to con...

Example Embodiment

[0027] Example 3.

[0028] Prescription composition: Qianghuo 1.5kg, Fangfeng 1.5kg, Atractylodes 1.5kg, Asarum 0.5kg, Ligusticum chuanxiong 1kg, Angelica dahurica 1kg, Scutellaria baicalensis 1kg, Licorice 1kg, Rehmannia glutinosa 1kg, Poloxamer and polyethylene glycol stearate 0.2 each kg, musk essence 0.3kg, cinnamon oil 0.2kg. A total of 250 bottles were made.

[0029] Use the following steps to prepare: the above nine Chinese medicinal materials, Qianghuo, Fangfeng, Cangzhu, Asarum, Chuanxiong, Angelica dahurica use supercritical CO 2 The volatile oil is extracted by fluid extraction technology (extraction pressure is 45MPa, extraction temperature is 70℃, extraction 2h). The extracted medicinal residue, scutellaria baicalensis, licorice, and rehmannia glutinosa are added with 10 times the amount of water, and ultrasonic extraction is performed twice, each time is 0.75h (Ultrasonic power 80W, ultrasonic frequency 20kHz, temperature 40℃), filter, concentrate the filtrate, conce...

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Abstract

The invention provides a preparation method of a notopterygium root spray of nine ingredients, relating to a preparation method of a traditional Chinese medicine spray. The notopterygium root spray of nine ingredients is composed of notopterygium root, divaricate saposhnikovia root, Chinese atractylodes, asarum herb, chuanxiong rhizome, angelia, baical skullcap root, licorice and rehmannia root. The preparation method comprises the following steps of: extracting volatile oils from the notopterygium root, the divaricate saposhnikovia root, the Chinese atractylodes, the asarum herb, the chuanxiong rhizome and the angelica; performing ultrasonic extraction on the dregs after extraction, the baical skullcap root, the licorice and the rehmannia root, filtering after extraction; concentrating the obtained filtrate, adding ethanol, standing and filtering; and concentrating the filtrate, recovering the ethanol, adding the volatile oils, a surfactant, an essence and a preservative to the concentrated solution, mixing evenly, supplementing distilled water, filtering, subpackaging and sterilizing. The preparation method provided by the invention has the characteristics of short extraction time, high yield, no need of heating, and the like, saves the production time, improves the extraction rate, avoids degradation of thermal instable ingredients, is favorable to full utilization of medicinal materials, and saves energy and cost.

Description

technical field [0001] The invention relates to a preparation method of a traditional Chinese medicine spray, in particular to a preparation method of a nine-flavor notopterygium spray. Background technique [0002] Jiuwei Qianghuo is composed of Qianghuo, Fangfeng, Cangzhu, Asarum, Chuanxiong, Baizhi, Scutellaria, Licorice, and Dihuang. It has the effects of relieving the exterior, dispersing cold, and dehumidifying. The combination of nine medicinal materials can not only cure wind-cold and damp pathogens, but also coordinate the exterior and interior. Together, they form a medicine for sweating and dampness, and at the same time clearing internal heat. It is a classic prescription for treating wind-cold and cold. [0003] The main documents that have publicly recorded Jiuwei Qianghuo include: Jiuwei Qianghuo Oral Liquid, Jiuwei Qianghuo Pills and Jiuwei Qianghuo Granules, which are included in the first part of the Pharmacopoeia of the People's Republic of China; the appl...

Claims

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Application Information

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IPC IPC(8): A61P29/00A61K9/12A61K36/804
Inventor 肖军平吴永忠余宝平余显英李旭郭锋张荷英
Owner JIANGXI POZIN PHARMA
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