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Burdock aglycone microemulsion

A technology of arctigenin and milk preparation, applied in the field of medicine, can solve the problems of low bioavailability, difficult preparation of microemulsion, poor water solubility and the like

Active Publication Date: 2014-06-04
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The bioavailability of intragastric administration in rabbits is only 9.5%. The main reason for the analysis is that arctigenin is a fat-soluble compound with poor water solubility, which leads to very low oral bioavailability.
Invention patent application publication specification CN 101036644A discloses a pharmaceutical composition containing arctigenin, the invention includes arctigenin in cyclodextrin derivatives to solve the problem of poor water solubility and bioavailability of arctigenin low problem
[0008] However, there are many difficulties in the preparation of microemulsions.

Method used

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  • Burdock aglycone microemulsion
  • Burdock aglycone microemulsion
  • Burdock aglycone microemulsion

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] Preparation and quality evaluation of embodiment 1 arctigenin microemulsion

[0064] 1. Prescription of arctigenin microemulsion concentrate

[0065] components

Weight / g

Arctigenin

5

Glyceryl Caprylate

15

Nonylphenol polyoxyethylene ether

50

1,2-propanediol

12.5

Absolute ethanol

12.5

[0066] 2. Preparation process of arctigenin microemulsion

[0067] Weigh the prescription amount of caprylic capric acid glyceride, nonylphenol polyoxyethylene ether, 1,2-propylene glycol, absolute ethanol, mix and stir evenly, then add arctigenin, ultrasonic treatment to accelerate the dissolution, and obtain a clear concentrated solution , which is arctigenin microemulsion concentrate. The microemulsion concentrate obtained above is diluted with water according to the weight ratio of 1:10-20 to a clear solution to obtain the microemulsion.

[0068] 3. Investigation of physical and chemical properties o...

Embodiment 2

[0096] Embodiment 2 microemulsion concentrate

[0097] components

[0098] Preparation process: Weigh the prescription amount of glyceryl caprylate, polyoxyethylene castor oil EL-40, and 1,2-propanediol, mix and stir evenly, then add arctigenin to dissolve, ultrasonicate to accelerate the dissolution, and obtain a clear concentrated solution, namely It is arctigenin microemulsion concentrate. The microemulsion concentrate obtained above is diluted with water according to the weight ratio of 1:10-20 to a clear solution to obtain the microemulsion. The particle size was measured by a laser particle size analyzer, and the average particle size was 15nm.

Embodiment 3

[0099] Embodiment 3 microemulsion concentrate

[0100] components

[0101] The preparation process is the same as in Example 2. The particle size was measured by a laser particle size analyzer, and the average particle size was 35nm.

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Abstract

A microemulsion formulation contains arctigenin and microemulsion carriers, said microemulsion carriers comprise oil phase and emulsifier, and the microemulsion has an average particle size of 10-90 nm.

Description

technical field [0001] The invention belongs to the field of medicine and relates to a microemulsion preparation. In particular, the present invention relates to microemulsion formulations of arctigenin. Background technique [0002] Arctium burdock is the dry and ripe fruit of the Compositae plant Burdock. It is a commonly used traditional Chinese medicine. It has the functions of evacuating wind-heat, clearing the lungs and rash, detoxifying and relieving the throat. It is used for wind-heat cold, cough with excessive phlegm, measles, rubella, sore throat, Pruritus mumps erysipelas, carbuncle sores. The traditional Chinese medicine contains lignans, mainly arctiin and arctigenin. Although the content of arctigenin (also known as arctigenin) in arctium is very low, but its precursor arctiin is high in the traditional Chinese medicine burdock and burdock burdock fruit, so a large amount of arctiin can be obtained through the conversion of arctiin aglycone. According to l...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/107A61K31/365A61K47/14A61K47/32A61K47/34A61K47/44A61P9/00A61P25/28A61P31/04A61P31/12A61P35/00
CPCA61K31/7048A61K9/1075A61K31/365A61P9/00A61P11/00A61P25/28A61P31/00A61P31/04A61P31/12A61P35/00
Inventor 赵志全郝贵周姚景春
Owner LUNAN PHARMA GROUP CORPORATION