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Medicament composition, and preparation and application thereof

A technology of pharmaceutical preparations and compositions, applied in the field of treatment, prevention of cardiovascular and cerebrovascular diseases, can solve problems such as bleeding, and achieve the effect of good antithrombotic activity

Active Publication Date: 2011-11-16
天津药物研究院药业有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the activity of the broad-spectrum anti-platelet aggregation drug clopidogrel is better than that of aspirin, there is still a risk of gastrointestinal bleeding in clinical use, and the risk of side effects is not significantly different from that of aspirin

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Antithrombotic effect of aspirin-diosgenin composition

[0019] 1. Materials:

[0020] 1.1 Reagents:

[0021] Heparin Sodium: Distributed by Tianjin Chemical Reagent Wholesale Department, batch number: 891125.

[0022] Sodium chloride: product of Tianjin Tanggu Chemical Reagent Factory.

[0023] Sodium carboxymethyl cellulose: product of Tianjin Fuchen Chemical Reagent Factory, batch number: 20050407.

[0024] Tween 80: product of Tianjin Fine Chemicals Co., Ltd., batch number: 920311.

[0025] 1.2 Drugs

[0026] Aspirin-diosgenin composition; provided by the Innovative Drug Research Center of Tianjin Pharmaceutical Research Institute;

[0027] Aspirin: as a reserved sample within the group;

[0028] Diosgenin: Provided by the Innovative Drug Research Center of Tianjin Pharmaceutical Research Institute;

[0029] The preparation method is 180mg+10d Tween+1%CMC-Na to 18ml;

[0030] 1.3 Animals

[0031] Wistar rats, male, weighing 260-320 g, were purchased from th...

Embodiment 2

[0041] Aspirin 50g and diosgenin 50g were granulated with appropriate amount of 15% starch slurry containing tartaric acid, dried, added 10% dry starch, 5% talcum powder and pressed into tablets to obtain 1000 tablets, specification: 100mg / tablet

Embodiment 3

[0043] Aspirin 40g, diosgenin 60g, lactose-microcrystalline fiber (5:1) 100g, use appropriate amount of tartaric acid to obtain 15% starch slurry to granulate, dry, add 10% dry starch, 5% talcum powder and press into tablets to obtain 1000 tablets , specification: 200mg / tablet

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PUM

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Abstract

The invention provides a medicament composition of aspirin and diosgenin in view of the limitations of antithrombotic medicaments. The composition has antithrombotic activity significantly higher than aspirin, can significantly reduce the therapeutic dose of aspirin, simultaneously has gastric mucosal protective effect, and can be safely used for long term.

Description

technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to a pharmaceutical composition with antithrombotic effect, its preparation, and its application in the prevention and treatment of cardiovascular and cerebrovascular diseases. technical background [0002] Platelet aggregation and thrombus formation are important causes of ischemic heart and brain injury. Platelet activation, adhesion and aggregation are one of the initiating factors of thrombosis in arteries, and play a role in the pathogenesis of atherosclerosis, coronary events (unstable angina, acute myocardial infarction, sudden cardiac ischemic death), stroke, etc. key role. Therefore, antiplatelet and anticoagulant therapy has become a hot spot in the treatment of reducing clinical ischemic events. [0003] Aspirin is the drug of choice for the prevention and treatment of arterial thrombosis. It is used to prevent transient ischemic attack, myocardial infarctio...

Claims

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Application Information

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IPC IPC(8): A61K31/616A61P7/02A61P9/00A61K31/58
Inventor 韩英梅张士俊付晓丽赵娜夏夏广萍
Owner 天津药物研究院药业有限责任公司
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