Preparation containing in-vitro cultivated calculus bovis for treating children cough, and preparation method thereof

A technology for cultivating bezoar and infantile cough in vitro, which can be applied to medical preparations containing active ingredients, anti-inflammatory agents, pharmaceutical formulas, etc., and can solve problems such as large differences in usage, low content of compound bilirubin calcium, and differences in clinical efficacy. , to ensure uniformity, improve symptoms and signs, and reduce moisture absorption

Inactive Publication Date: 2011-11-23
汤明昌 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As far as active ingredients are concerned, in the current statutory standards, the bilirubin (active ingredient) contained in artificial bezoar should not be less than 0.63%, while the bilirubin contained in in vitro cultivated bezoar and natural bezoar should not be less than 35.0%, according to Existing data show that the active ingredients of in vitro cultured bezoar and natural bezoar are compound bilirubin calcium, cholic acid and other active ingredients, while the content of compound bilirubin calcium in artificial bezoar is very low, mainly composed of free bilirubin, The clinical curative effect is far from that of natural bezoar and in vitro cultured bezoar
[0010] 2. The existing Baokening granules are made of artificial bezoar and other 15 herbal medicinal materials. Since the amount of artificial bezoar is greatly different from that of other drugs and auxiliary materials, the original mixing method (i.e. extracting medicinal materials) Clear ointment, add appropriate amount of sucrose and dextrin, and directly mix with imported bezoar fine powder to make granules) can not guarantee the uniformity of artificial bezoar dispersion in the medicine; in vitro cultured bezoar belongs to expensive and fine medicinal materials, and it can be used instead of artificial bezoar for medicine If you continue to prepare granules according to the original mixing method, the uneven dispersion of precious and fine medicinal materials will directly affect the efficacy of the drug

Method used

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  • Preparation containing in-vitro cultivated calculus bovis for treating children cough, and preparation method thereof
  • Preparation containing in-vitro cultivated calculus bovis for treating children cough, and preparation method thereof
  • Preparation containing in-vitro cultivated calculus bovis for treating children cough, and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0192] In vitro cultured bezoar 3g, perilla leaves 30g, mulberry leaves 30g, peucedanum 60g, Fritillaria 30g, ephedra 30g, bellflower 30g, araceae (made) 60g, tangerine peel 30g, bitter almond (fried) 60g, scutellaria baicalensis 60g, Qingdai 21g , trichosanthes 60g, citrus aurantium (fried bran) 60g, hawthorn (fried) 45g, licorice 15g

[0193] The above sixteen flavors are prepared into granules according to the following steps.

[0194] Step 1: Take the in vitro cultured bezoar and crush it into fine powder, pass through a 150-mesh sieve, and set aside;

[0195] Step 2: extract volatile oil from perilla leaves and tangerine peel, and collect the distilled aqueous solution in another device; , Citrus aurantii (stir-fried bran), hawthorn (stir-fried), licorice and other thirteen flavors are decocted twice, the first time is 2.5 hours, the second time is 1.5 hours, the decoction is combined, filtered, the filtrate is combined with the above aqueous solution, and concentrated ...

Embodiment 2

[0202] In vitro cultured bezoar 0.3kg, perilla leaves 3kg, mulberry leaves 3kg, peucedanum 6kg, Fritillaria 3kg, ephedra 3kg, bellflower 3kg, araceae (manufactured) 6kg, tangerine peel 3kg, bitter almond (fried) 6kg, scutellaria baicalensis 6kg, Qingdai 2.1kg, trichosanthemi 6kg, citrus aurantium (fried bran) 6kg, hawthorn (fried) 4.5kg, licorice 1.5kg

[0203] The above sixteen flavors are prepared into granules according to the following steps.

[0204] Step 1: Take the in vitro cultured bezoar and crush it into fine powder, pass through a 150-mesh sieve, and set aside;

[0205] Step 2: extract volatile oil from perilla leaves and tangerine peel, and collect the distilled aqueous solution in another device; , Citrus aurantii (stir-fried bran), hawthorn (stir-fried), licorice and other thirteen flavors are decocted twice, the first time is 2.5 hours, the second time is 1.5 hours, the decoction is combined, filtered, the filtrate is combined with the above aqueous solution, a...

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Abstract

The invention discloses a preparation containing in-vitro cultivated calculus bovis for treating children cough, and a preparation method thereof. The preparation is characterized in that: the preparation is prepared from materials of, by weight: 2 to 4 parts of in-vitro cultivated calculus bovis, 20 to 40 parts of purple perilla leaf, 20 to 40 parts of mulberry leaf, 40 to 80 parts of radix peucedani, 20 to 40 parts of Chekiang fritillary bulb, 20 to 40 parts of ephedra stem, 20 to 40 parts of balloonflower root, 40 to 80 parts of arisaema erubescens (wall.) schott (prepared), 20 to 40 parts of tangerine peel, 40 to 80 parts of bitter apricot kernel (stir-fried), 40 to 80 parts of baikal skullcap root, 14 to 28 parts of natural indigo, 40 to 80 parts of trichosanthes root, 40 to 80 parts of submature bitter orange (stir fried with bran), 30 to 60 parts of chinese hawthorn fruit (stir-fried), 10 to 20 parts of licorice, a proper amount of cane sugar, and a proper amount of dextrin. According to the invention, artificial bovis is substituted by in-vitro cultivated calculus bovis, such that problems of preparation safety and preparation efficiency are solved. With crushing and mixing methods aimed at valuable material in-vitro cultivated calculus bovis, dispersion uniformity of in-vitro cultivated calculus bovis can be ensured.

Description

technical field [0001] The invention relates to a preparation containing in vitro cultured bezoar for treating cough in children and a preparation method, belonging to the technical field of medicine production. Background technique [0002] The common cold and influenza in children are the most common childhood illnesses, often causing symptoms such as headache, body fever, cough with phlegm, shortness of breath, sore throat, restlessness and so on. [0003] In the classification of TCM syndromes, it belongs to exterior cold and interior heat syndrome. The onset of symptoms is usually upper respiratory tract infection symptoms. The cough is not severe at the beginning, but it is irritating and has little sputum. After 1 to 2 days, the cough intensifies, and the sputum changes from viscous to mucopurulent. Severe cases often have paroxysmal cough after getting up in the morning, going to bed late, changing body position, inhaling cold air or physical activity, sometimes even...

Claims

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Application Information

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IPC IPC(8): A61K36/8966A61K9/16A61P11/14A61P29/00A61P11/10A61P11/06A61P11/04A61K35/413
Inventor 不公告发明人
Owner 汤明昌
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