Preparation method of nicotinic acid

Abstract

The invention relates to a preparation method of nicotinic acid, which comprises the following steps: placing 700-900 parts of 3-cyanopyridine in a container, adding 1600-1800 parts of de-ionized water into the 3-cyanopyridine in the container, and stirring to obtain a solution; dropwisely adding 760-770 parts of 40% sodium hydroxide solution at 90-95 DEG C, and reacting for 58-62 minutes to generate a sodium nicotinate solution; diluting the solution to 15%; passing the 15% sodium nicotinate solution through an ammonium cation exchange resin layer for ion exchange at a flow rate of 300 liters per hour, collecting to obtain an ammonium nicotinate solution; and evaporating the ammonium nicotinate solution to dryness so as to obtain nicotinic acid. In the invention, 3-cyanopyridine used as the raw material reacts with the sodium hydroxide solution used as hydrolytic agent at a temperature above 90 DEG C for 58-62 minutes to obtain sodium nicotinate. Thus, compared with the prior art, the invention overcomes the defects of high equipment requirements and large equipment corrosion of the original technology, and has the advantages of simpler process, more convenient operation, less waste, lower cost and higher conversion rate.

Description

technical field

[0001] The invention relates to the technical field of chemical intermediate synthesis, in particular to a preparation method of nicotinic acid. Background technique

[0002] Niacin also known as vitamin B 3 , or vitamin PP, molecular formula: C 6 h 5 NO 2 , heat resistance, can sublimate. Nicotinic acid is also known as nicotinic acid and anti-peaceae factor. In the human body also includes its derivative nicotinamide or nicotinamide. It is one of the 13 kinds of vitamins necessary for the human body. It is a water-soluble vitamin and belongs to the vitamin B group. Nicotinic acid is converted into nicotinamide in the human body. Niacinamide is a component of coenzyme I and coenzyme II, and participates in lipid metabolism in the body, the oxidation process of tissue respiration and the process of anaerobic decomposition of carbohydrates. The product and nicotinamide are collectively referred to as vitamin PP, which is used to resist pellagra, and can...