Substituted triazine phenyl urea derivatives and application thereof

A kind of technology of substituent and compound, applied in the field of substituted triazine phenylurea derivatives and their uses, can solve problems such as no effect
CN102250065AInactive Publication Date: 2011-11-23ZHEJIANG HISUN PHARMA CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
ZHEJIANG HISUN PHARMA CO LTD
Publication Date
2011-11-23
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to substituted triazine phenyl urea derivatives and application of the derivatives used as protein kinases, especially as Raf-1 inhibitors. The compounds provided by the invention can be used for treating various disorders and diseases, especially the protein-kinase-related diseases such as cancers, miocardial infarction, cerebral thrombosis, anaemia, hepatitis C (HCV) and other diseases.
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Description

Technical field

[0001] The present invention relates to substituted triazine phenylurea derivatives and their application as inhibitors of protein kinases, especially Raf-1. The compounds of the present invention can be used to treat various disorders and diseases, especially diseases related to protein kinases, such as cancer. , Myocardial infarction, cerebral thrombosis, anemia and hepatitis C (HCV), etc. Background technique

[0002] Many processes of tumor production, growth and metabolism are regulated by cell signaling pathways triggered by activated tyrosine kinases. RAS (a proto-oncogene, named after it was first discovered in the rat sarcoma virus) can regulate several downstream receptor tyrosine kinases (RTKs). The activation of the RAS cell signaling pathway is a key step in the growth of human cancer cells. The activation process of the RAS channel is caused by the activation of the mutation of the RAS oncogene, or the influencing factors of the downstream RAS. Th...

Claims

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