A kind of high-content liquid gingerol and preparation method thereof

A high-content technology of gingerol, which is applied in the field of plant extracts and its preparation, can solve the problems of heavy metal residues in products, low separation efficiency, and high production costs, and achieve better product quality, good repeatability, and quality. Guaranteed effect

Active Publication Date: 2011-11-30
湖南和广生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] So far, the methods for preparing high-content gingerol mainly include solvent extraction separation-multiple solvent extraction methods, supercritical extraction combined with column chromatography methods, etc., these methods have to go through higher temperatures in the separation and purification process, or use A large amount of organic solvents, or contact with separation materials containing a lot of heavy metals, will easily lead to product changes or heavy metal residues, and the disadvantages are complicated process, low separation efficiency, and high production cost.

Method used

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  • A kind of high-content liquid gingerol and preparation method thereof
  • A kind of high-content liquid gingerol and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] The preparation method of the high-content liquid gingerol described in the present embodiment may further comprise the steps:

[0034] (1) With 0.5 kilogram of ginger resin, its gingerol content is 38.2%, the condition of supercritical carbon dioxide extraction is: extraction pressure / temperature 30MPA / 40 ℃, primary separation pressure / temperature 12MPA / 45 ℃, secondary separation pressure / Temperature 5MPA / 35°C. The ginger resin is obtained in the primary separator, and mainly volatile components in the secondary separator. Adding 2.25 kilograms of weight percent concentration in ginger resin is 70% ethanol aqueous solution, stirs, removes a small amount of insoluble matter by filtration, obtains clear ginger resin alcohol solution;

[0035] (2) if figure 1 As shown, the alcohol solution of the above-mentioned ginger resin is transferred to a glass liquid-liquid extractor (90 mm in diameter × 1100 mm in height), and then petroleum ether (boiling range 60 to 90° C.) i...

Embodiment 2

[0039] The preparation method of the high-content liquid gingerol described in the present embodiment may further comprise the steps:

[0040](1) With 1.0 kilograms of ginger resin, its gingerol content is 39.4%, the condition of supercritical carbon dioxide extraction is: extraction pressure / temperature 30MPA / 45 ℃, primary separation pressure / temperature 13MPA / 45 ℃, secondary separation pressure / Temperature 5MPA / 35°C. The ginger resin is obtained in the primary separator, and mainly volatile components in the secondary separator. Adding 4.0 kilograms of concentration by weight wherein is 75% ethanol aqueous solution, stirs, removes a small amount of insoluble matter by filtration, obtains clear ginger resin alcohol solution;

[0041] (2) the alcoholic solution of above-mentioned ginger resin is transferred in the glass liquid-liquid extractor (diameter 90 millimeters × height 1100 millimeters), then sherwood oil (boiling range 60~90 ℃) is passed through the bottom of the ex...

Embodiment 3

[0045] The preparation method of the high-content liquid gingerol described in the present embodiment may further comprise the steps:

[0046] (1) With 2.0 kilograms of ginger resin, its gingerol content is 37.1%, the condition of supercritical carbon dioxide extraction is: extraction pressure / temperature 32MPA / 45 ℃, primary separation pressure / temperature 14MPA / 50 ℃, secondary separation pressure / Temperature 5MPA / 35°C. The ginger resin is obtained in the primary separator, and mainly volatile components in the secondary separator. Adding 7.5 kilograms of weight percent concentration therein is the ethanol aqueous solution of 80%, stirs, removes a small amount of insoluble matter by filtration, obtains clear ginger resin alcohol solution;

[0047] (2) the alcoholic solution of above-mentioned ginger resin is transferred in the glass liquid-liquid extractor (diameter 110 millimeters × height 1300 millimeters), then with metering pump 8 petroleum ether (boiling range 60~90 ℃) ...

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Abstract

The invention discloses high-content liquid gingerols and a preparation method thereof. In the preparation method, on the basis of the characteristics that components in high-quality pure natural ginger resin obtained through supercritical carbon dioxide extraction have greater difference in solubility in ethanol and petroleum ether with certain concentration, liposoluble impurity components are continuously extracted from an ethanol phase with the petroleum ether, and extraction separation and purification are further performed by using diethyl ether to finally obtain the high-content liquidgingerols. The high-content liquid gingerols is light brownish red liquid with worse fluidity and has the advantages of elegant and pure fragrance and durable base note, moreover, gingerols content is higher than 90%, and residual quantities of heavy metals such as arsenic, cadmium, lead, mercury and the like are all less than 0.1ppm.

Description

technical field [0001] The invention relates to a plant extract and a preparation method thereof, in particular to a high-content gingerol and a preparation method thereof. Background technique [0002] Ginger is a medicinal and edible plant that is closely related to people's life and health. Regardless of ancient or modern times, or at home and abroad, ginger and its products have never left people's lives. Studies have shown that the main active ingredients of raw (dry) ginger are volatile oil and gingerol. Gingerol is a general term for a variety of structurally similar substances in raw (dry) ginger, all of which contain 3-methoxy-4-hydroxyphenyl functional groups, mainly including gingerols (Gingerols) , Shogals, Paradols, Zingerones, Gingerdiones, Gingerdiols, and gingerol is its main component. [0003] Modern pharmacological research has found that gingerol is the main active ingredient in the pharmacological effects of ginger and its preventive and health care ef...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61K31/12A61P7/02A61P3/06A61P9/10A61P9/00A61P1/04A61P1/16A61P29/00A61P31/12A61P25/08A61P39/06A61P35/00A61P37/08A61P17/16A61P1/08
Inventor 曾健青左雄军
Owner 湖南和广生物科技有限公司
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