A kind of slow-release magnetic particles of total alkaloids of Sophora japonica and preparation method thereof
A technology of magnetic particles and bitter bean seeds, which can be used in pharmaceutical formulations, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc., can solve adverse drug reactions, poor patient compliance, toxic side effects, and increased complications, etc. problems, to achieve the effect of good patient compliance, low medication frequency, and high bioavailability
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Embodiment 1
[0028] (1) dissolving chitosan in an aqueous acetic acid solution with a volume ratio of 0.2% to 2%, and the concentration of chitosan in the aqueous acetic acid solution is 0.005 to 0.05g / mL to obtain an acetic acid solution of chitosan. The preparation method of the chitosan acetic acid solution in the following each embodiment is the same.
[0029] (2) Preparation of Sophora sophora total alkali drug-loaded magnetic particles: get 0.6g of Sophora sophora total alkali extract and add in 6ml of 0.025g / mL chitosan 1% acetic acid solution, then add microcrystalline cellulose (cellulose content is 97.0%~102%, the colloidal viscosity can reach 3000~5000mPa s when the concentration is 3%, the microcrystalline cellulose in other embodiments of the present invention is the same) 0.9g and iron ferric oxide nanoparticles (particle size is 20nm, The iron ferric oxide nanoparticle particle size in other embodiments of the present invention is the same as this) 0.9g, stir evenly, make so...
Embodiment 2
[0032] (1) Preparation of the total alkaloid drug-loaded magnetic particles of Sophora sophorae: Take 0.6 g of total alkaloid extract of Sophora sophora and add it to 8 mL of 0.025 g / mL chitosan 1% acetic acid solution, then add 0.9 g of microcrystalline cellulose and tetraoxide Three iron nanoparticles 0.9g, stir evenly, make soft material. Pass through a 65-mesh sieve to granulate, dry at a constant temperature of 50°C, sieve through a 65-mesh sieve, and granulate to obtain drug-loaded magnetic particles.
[0033] (2) Preparation of slow-release magnetic particles of Sophora sophora total alkaloids: get 1.3 g of chitosan, add 52 ml of 1% acetic acid aqueous solution, wait for its natural peptization, stir well, and spray the chitosan acetic acid solution on the drug-loaded magnetic particles surface, or wrap the drug-loaded magnetic particles in chitosan-acetic acid solution, repeat the spraying or wrapping process several times, sieve through a 50-mesh sieve, size the parti...
Embodiment 3
[0035] (1) Preparation of Sophora sophorae total alkali drug-loaded magnetic particles: Take 0.6 g of Sophora sophora sophora total alkali extract and add it to 6 ml of 0.025 g / mL chitosan 1% acetic acid solution, then add microcrystalline cellulose 1.2 g and tetroxide 1.2g of three iron nanoparticles, stirred evenly, made soft material. Pass through a 65-mesh sieve to granulate, dry at a constant temperature of 50°C, sieve through a 65-mesh sieve, and granulate to obtain drug-loaded magnetic particles.
[0036] (2) Preparation of slow-release magnetic particles of total alkaloids of Sophora sophora: take 1.65 g of chitosan, add 66 ml of 1% acetic acid aqueous solution, wait for its natural peptization, stir well, and spray the chitosan acetic acid solution on the drug-loaded magnetic particles surface, or wrap the drug-loaded magnetic particles in chitosan-acetic acid solution, repeat the spraying or wrapping process several times, sieve through a 50-mesh sieve, size the partic...
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