A chemical enzymatic resolution preparation method of (r)-1-(1-naphthyl)ethylamine
A chemical enzyme and ethylamine technology, which is applied in the field of chemical enzyme resolution of (R)-1-(1-naphthyl)ethylamine, can solve the problems of low yield, large pollution, poor optical selectivity, etc., and achieve The effect of high catalytic efficiency and high optical purity
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Embodiment 1
[0014] A (R) -1- (1-萘) chemical enzyme split preparation method of ethyne. The 1- (1-萘 ethyl) ethyleine of 1- (1-萘 萘) is the raw material, and the alcohol ethyl acetateSupply, fixed Antarctic Ferrye yeast lipase is catalyst, toluene is a solvents, for dynamic splitting, the operating conditions are controlled as follows: temperature 30 ° C, the volume ratio of the raw material and solvents is 1: 25, the quality ratio of raw materials and catalysts is to the mass ratio of the catalyst is to be the mass ratio of the catalyst to1: 0.02, the Moorbi of the raw material and the alcohol ethyl acetate is 1: 1.2.After 48 hours of reaction, the conversion rate of the substrate can reach 48%, and the E.E. value of the product can reach more than 99%.
Embodiment 2
[0016] A (R) -1- (1-萘) chemical enzyme split preparation method of ethyne. The 1- (1-萘 ethyl) ethyleine of 1- (1-萘 萘) is the raw material, and the alcohol ethyl acetateSupply, fixed Antarctic fake silk yeast lipase is catalyst, toluene is a solvents, for dynamic splitting, the operating conditions are controlled as follows: temperature 40 ° C, the volume ratio of the raw material and the solvents is 1: 30, the quality ratio of raw materials and catalysts is to the mass ratio of catalysts to1: 0.025, the Moorbi of the ingredients and benzoryl ethyl acetate is 1: 2.0.After 42 hours of reaction, the conversion rate of the substrate can reach 48%, and the E.E. value of the product can reach more than 99%.
Embodiment 3
[0018] A (R) -1- (1-萘) chemical enzyme split preparation method of ethyne. The 1- (1-萘 ethyl) ethyleine of 1- (1-萘 萘) is the raw material, and the alcohol ethyl acetateSupply, fixed Antarctic Ferrye yeast lipase is catalyst, toluene is a solvents, for dynamic splitting, the operating conditions are controlled as follows: temperature 50 ° C, the volume ratio of the raw material and solvents is 1: 35, the quality ratio of raw materials and catalysts is to the mass ratio of the catalyst is1: 0.03, the Moorbi of the raw material and the alcohol ethyl acetate is 1: 3.0.After 38 hours of reaction, the conversion rate of the substrate can reach 50%, and the E.E. value of the product can reach more than 99%.
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