A kind of preparation method of α-tocopheryl acetate

Abstract

The invention discloses a method for preparing alpha-tocopheryl acetate. According to the method, a condensation reaction is carried out on the raw materials including trimethylhydroquinone and isophytol. A catalyst is a mixture of concentrated sulfuric acid and 1-butyl-3-methylimidazolium bis[(trifluoromethyl)sulfonyl]imide or a mixture of concentrated sulfuric acid and 1-ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide. The method disclosed by the invention comprises two main steps of firstly carrying out the condensation reaction to prepare an alpha-tocopheryl crude product and esterifying the alpha-tocopheryl crude product. According to the method disclosed by the invention, the addition amount of the catalyst can be largely reduced during production, and the recycle operation program of the catalyst is simplified; simultaneously, the corrosivity of matters in a system on a reactor is low, the generation of waste water including halogen ions, zinc ions and iron ions is avoided, the production condition is gentle, and the indiscriminate use ratio of the catalyst is higher, thus the invention has the advantage of remarkably reduced comprehensive cost.

Description

technical field [0001] The present invention relates to a process for the preparation of alpha-tocopheryl acetate. Background technique [0002] Vitamin E, also known as tocopherol, has an anti-oxidant effect. It has an important impact on the reproductive function and lipid metabolism of the human body. Vitamin E deficiency will cause related diseases. Among them, α-tocopherol is a form of vitamin E that is widely distributed and has the highest activity in nature. Since natural α-tocopherol alone is far from meeting the needs, a considerable part of it is artificially synthesized; and in most cases, it is esterified to make a more stable and oxidatively stronger α-tocopherol. Phenyl acetate. The existing artificial synthesis method is to allow trimethylhydroquinone (C 9 h 12 o 2 ) and isophytol (C 20 h 40 O) A condensation reaction is carried out to obtain a crude product, which is then esterified to obtain the finished product α-tocopheryl acetate. In the prior ar...

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Problems solved by technology

These catalysts have the advantage of mild reaction conditions; but there is a large amount of catalyst (based on trimethylhydroquinone, compared with mass, the amount of these catalysts is 1 to 1.2 times that of trimethylhydroquinone), and the catalyst It is difficult to recycle, the corrosion of equipment is serious, and the environmental pollution is relatively large.

After changing the catalyst to boron trifluoride, it can overcome some of the above-mentioned shortcomings of the catalyst. However, boron trifluoride still has a strong corrosive effect on the equipment, and the requirements for product purification are relatively high and strict. Otherwise, the remaining boron trifluoride will bring toxic side effects to the product

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