A kind of preparation method of α-tocopheryl acetate

A technology of tocopherol acetate and concentrated sulfuric acid, applied in the direction of organic chemistry, chemical recovery, etc., can solve the problems of difficult catalyst recovery, large amount of catalyst, toxic and side effects of products, etc., and achieves easy recovery and application, easy recovery, and catalyst usage. less effect

Inactive Publication Date: 2011-12-21
CHONGQING UNIV
View PDF4 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These catalysts have the advantage of mild reaction conditions; but there is a large amount of catalyst (based on trimethylhydroquinone, compared with mass, the amount of these catalysts is 1 to 1.2 times that of trimethylhydroquinone), and the catalyst It is difficult to recycle, the corrosion of equipment is serious, and the environmental pollution is relatively larg

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of preparation method of α-tocopheryl acetate
  • A kind of preparation method of α-tocopheryl acetate
  • A kind of preparation method of α-tocopheryl acetate

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0014] A kind of preparation method of α-tocopherol acetate, this method is to use catalyst to promote the method for condensation reaction of raw material trimethylhydroquinone and isophytol, in the present invention, described catalyst is concentrated sulfuric acid (H 2 SO 4 ) and amine ionic liquid, wherein the amine ionic liquid is 1-butyl-3-methylimidazolium trifluoromethanesulfonimide salt ([Bmim]Tf 2 N) or 1-ethyl-3-methylimidazoline bis(trifluoromethylsulfonyl)imide (C 6 h 11 N 2 ·C 2 f 6 NO 4 S 2 ); the method steps are as follows:

[0015] (1) Slowly add concentrated sulfuric acid to acetic acid C at 0°C under stirring 2～4 In the alkyl ester, to prepare the reaction solvent; Among them, acetic acid C 2～4 The purity of the alkyl esters is 99.5%; the volume ratio of the amount of added concentrated sulfuric acid to the total amount of the reaction solvent is 0.2~0.3:5;

[0016] It is clear to those skilled in the art that the concentration of concentrated sul...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a method for preparing alpha-tocopheryl acetate. According to the method, a condensation reaction is carried out on the raw materials including trimethylhydroquinone and isophytol. A catalyst is a mixture of concentrated sulfuric acid and 1-butyl-3-methylimidazolium bis[(trifluoromethyl)sulfonyl]imide or a mixture of concentrated sulfuric acid and 1-ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide. The method disclosed by the invention comprises two main steps of firstly carrying out the condensation reaction to prepare an alpha-tocopheryl crude product and esterifying the alpha-tocopheryl crude product. According to the method disclosed by the invention, the addition amount of the catalyst can be largely reduced during production, and the recycle operation program of the catalyst is simplified; simultaneously, the corrosivity of matters in a system on a reactor is low, the generation of waste water including halogen ions, zinc ions and iron ions is avoided, the production condition is gentle, and the indiscriminate use ratio of the catalyst is higher, thus the invention has the advantage of remarkably reduced comprehensive cost.

Description

technical field [0001] The present invention relates to a process for the preparation of alpha-tocopheryl acetate. Background technique [0002] Vitamin E, also known as tocopherol, has an anti-oxidant effect. It has an important impact on the reproductive function and lipid metabolism of the human body. Vitamin E deficiency will cause related diseases. Among them, α-tocopherol is a form of vitamin E that is widely distributed and has the highest activity in nature. Since natural α-tocopherol alone is far from meeting the needs, a considerable part of it is artificially synthesized; and in most cases, it is esterified to make a more stable and oxidatively stronger α-tocopherol. Phenyl acetate. The existing artificial synthesis method is to allow trimethylhydroquinone (C 9 h 12 o 2 ) and isophytol (C 20 h 40 O) A condensation reaction is carried out to obtain a crude product, which is then esterified to obtain the finished product α-tocopheryl acetate. In the prior ar...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): C07D311/72
CPCY02P20/584
Inventor 刘作华孙瑞祥陶长元杜军范兴吴春霞刘仁龙孙大贵左赵宏谢昭明李泽全
Owner CHONGQING UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap