A kind of refining method of creatine phosphate disodium salt

Abstract

The invention discloses a refining method of disodium phosphocreatine. The method comprises steps that: a sodium phosphocreatine crude product is dissolved in water, the solution is filtered, and a micro-molecular solvent is dropped into the filtrate while stirring, such that a large amount of oily matters are precipitated; the oily matters are settled and precipitated, a supernatant is removed, methanol is dropped into the oily matters while stirring, a large amount of crystals are precipitated, and the crystals are beaten and filtered; the filter cake is transferred into a reaction bottle, washed by using a micro-molecular solvent while stirring, and is filtered; the filter cake is dried with reduced pressure at a temperature of 40 to 45 DEG C, such that disodium phosphocreatine tetrahydrate with a high quality is obtained. The refining method provided by the invention has advantages of mild technical condition, simple and easy-to-control method, high yield, and stable product quality. The method satisfies the requirement of large-scale productions, and brings in good social and economic benefits.

Description

technical field [0001] The invention relates to a method for refining creatine phosphate disodium salt, in particular to a method for refining creatine phosphate disodium salt tetrahydrate. [0002] Background technique [0003] Creatine phosphate disodium salt (also known as creatine phosphate sodium salt) is an important derivative of creatine and a high-energy storage substance in the human body. Its tetrahydrate (that is, creatine phosphate sodium) has been widely used as One of the prevention and treatment medicines for various heart diseases, in addition to being taken directly as a nutritional product, it can also be widely used in clinical diagnosis as a biochemical agent. At present, the forms of creatine phosphate disodium salt recognized by researchers include creatine phosphate disodium salt hexahydrate and creatine phosphate disodium salt tetrahydrate, and now the tetrahydrate can be directly used in pharmaceuticals , and the relevant pharmaceutical and clinic...

AI Technical Summary

Problems solved by technology

These two methods are obtained and it is easier to obtain crystalline high-water-containing hexahydrate. Although this kind of crystal has medicinal prospects, its research is not yet mature.

[0006] For the tetrahydrate of creatine phosphate disodium salt (i.e. creatine phosphate sodium), Chinese patent CN101812088A uses a preparation chromatographic column for separation and purification to obtain creatine phosphate sodium Refined products, this method uses chromatographic columns to refine, not only the cost is high, the process conditions are complicated, and it is not conducive to industrial production

Chinese patent CN101492470A uses high-volume ethanol for repeated recrystallization. This method takes a long time to crystallize and uses a large amount, and needs to be repeated many times. Not only is the cost high, but the timeliness is poor

Chinese patent CN101486730A directly adds water-containing ethanol and crystallizes after standing still for a long time. This process takes a long time, the product quality is not high, and the yield is low, which is not conducive to large-scale production.

However, the yield of methanol refining crystallization is very low, and the scale of ultrasonic crystallization of ethanol is small, which are not conducive to industrial production.

[0008] All of the above methods cannot obtain high-quality and high-yield creatine phosphate sodium under the condition of low cost, and the timeliness is not good, and some links are difficult to control, and Leading to unstable product quality, it is difficult to achieve large-scale production