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Extraction method of key components of Chinese magnoliavine fruit medicament

An extraction method and a technology of key components, which are applied in the extraction of key components of medicines in Schisandra chinensis, and in the field of extraction of key components of Schisandra medicines, can solve the problems of less research on volatile oil of Schisandra chinensis, increased difficulty in product drying, and long extraction cycle and other issues, to achieve the effect of improving comprehensive utilization value, low production cost and high yield

Inactive Publication Date: 2013-05-01
INST OF PROCESS ENG CHINESE ACAD OF SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Schisandra volatile oil, as a bioactive component of traditional Chinese medicine, has good development and application prospects, but at present, there are few researches on the volatile oil of Schisandra chinensis at home and abroad, and it has not been developed and utilized.
The disadvantages of alcohol extraction and alcohol extraction after first boiling are: the extraction method has a long period, high temperature, and low extraction rate
Microwave extraction is time-consuming, solvent-saving, and easier to operate, especially the current single-focus microwave extraction can greatly reduce the risk of operation; the disadvantage is that polar solvents are required, and the extracted Schisandra lignan products contain a large amount of Volatile oil greatly increases the difficulty of product drying

Method used

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  • Extraction method of key components of Chinese magnoliavine fruit medicament
  • Extraction method of key components of Chinese magnoliavine fruit medicament
  • Extraction method of key components of Chinese magnoliavine fruit medicament

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] Crush Schisandra chinensis to 30-80 mesh, weigh 40g, add 400mL of water to soak for 12h, heat in an oil bath, stop heating after 5h while keeping a slight boil, leave it for a while, open the piston at the lower end of the volatile oil tester, and slowly release the water , until the upper end of the oil layer reaches 5mm above the 0 line on the scale. Leave it for 1-2 hours, then open the piston to collect the volatile oil in the lower layer, and use anhydrous Na 2 SO 4 After drying, 0.58 mL of Schisandra volatile oil was obtained.

[0060] Concentrate the mixed solution after oil extraction to 123.7g by evaporation under reduced pressure, add 320mL of methanol, at 20°C, ultrasonic power 800w, ultrasonication for 15min, and then suction filtration to obtain Schisandra lignan extract.

[0061] The schisandra lignan extract was concentrated to 80 g under reduced pressure, washed with 120 g of water, left to stand for about 14 hours, and the lower solid phase was remove...

Embodiment 2

[0063] Crush Schisandra chinensis to 30-80 mesh, weigh 50g, add water 400mL, soak for 6h, heat in an oil bath, stop heating after 5h while keeping a slight boil, leave it for a while, open the piston at the lower end of the volatile oil tester, and slowly release the water, Until the upper end of the oil layer reaches 5mm above the 0 line on the scale. Leave it for 1-2 hours, then open the piston to collect the volatile oil in the lower layer, add anhydrous Na 2 SO 4 After drying, 0.7 mL of Schisandra volatile oil was obtained.

[0064] Concentrate the mixed solution after oil extraction to 147g by evaporation under reduced pressure, add 400mL of methanol, at 20°C, ultrasonic power 600w, ultrasonic 20min, and then suction filter to obtain Schisandra lignan extract.

[0065] The schisandra lignan extract was concentrated to 124.3 g under reduced pressure, washed with 100 g of water, left to stand for about 10 hours, and the lower solid phase was removed to dry to obtain 0.72 ...

Embodiment 3

[0067] Crush Schisandra chinensis to 30-80 mesh, weigh 40g, add 400mL of water and soak for 12h, heat in an oil bath, stop heating after 5h while maintaining slight boiling, let it stand for a while, open the piston at the lower end of the volatile oil tester, and slowly release the water, Until the upper end of the oil layer reaches 5mm above the 0 line on the scale. Leave it for 1-2 hours, then open the piston to collect the volatile oil in the lower layer, add anhydrous Na 2 SO 4 After drying, 0.6 mL of Schisandra volatile oil was obtained.

[0068] The mixed solution after oil extraction was evaporated and concentrated under reduced pressure to 121.6g, and 320mL of methanol was added, at 20°C, with an ultrasonic power of 800w, for 15min, and then suction-filtered to obtain a schisandra lignan extract.

[0069] Concentrate the extract of Schisandra lignans to 88g under reduced pressure, add 300mL of petroleum ether, ultrasonically extract for 45min, take the petroleum eth...

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Abstract

The invention discloses an extraction method of key components of a Chinese magnoliavine fruit medicament. The extraction method comprises the following steps: extracting volatile oil from Chinese magnoliavine fruit powder which serves as a raw material by adopting a steam distillation method; extracting schisandra lignanoids from residues after the volatile oil is extracted by using an ultrasonic circular extraction method; and purifying by a water precipitation or petroleum ether extraction method so as to improve the content of the schisandra lignanoids in a product. According to the method, two active components, namely volatile oil and lignanoids, in the Chinese magnoliavine fruit are simultaneously extracted, and the comprehensive utilization value of the Chinese magnoliavine fruit medicinal material is remarkably improved.

Description

technical field [0001] The invention relates to a method for extracting Chinese medicinal materials, in particular to a method for extracting key components of schisandra chinensis, in particular to a method for extracting key components of schisandra chinensis. The new extraction method can simultaneously obtain the two key component products of schisandra volatile oil and lignan. Background technique [0002] Schisandra chinensis is commonly known as mountain pepper, weighing tuozi, medicine schisandra, noodle vine, five plums, etc., and is the dry and mature fruit of Magnoliaceae Schisandra chinesnsis Baill. Tang et al.'s "Xinxiu Materia Medica" contains "the five flavors are sweet and sour in the skin and flesh, and hard in the core, all of which have a mature flavor", so it is named Schisandra. Ancient medical books call it Chuzhu, Xuanji, and Huiji, which were first listed in the top grade of Shennong’s Herbal Classic. The efficacy of traditional Chinese medicine lies...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/57C07C43/23C07C41/34C07D317/70A61P25/28A61P9/00A61P1/00A61P11/14A61P1/16A61P39/06A61P31/18A61P35/00A61K131/00
Inventor 肖清贵周玲徐红彬孙玉良高毅颖王学魁张懿
Owner INST OF PROCESS ENG CHINESE ACAD OF SCI