Highly active catalyst used for hydrosilation reaction of aldehyde and trimethylsilyl cyanide

Abstract

Belonging to the field of organic synthesis, the invention relates to a highly active catalyst used for a hydrosilation reaction of aldehyde and trimethylsilyl cyanide so as to synthesize a cyanohydrinsilylether compound. The catalyst is characterized by being a quaternary ammonium base or an alkali metal hydroxide both containing one or two hydroxyl anions. The catalyst can catalyze the hydrosilation reaction of aldehyde and trimethylsilyl cyanide efficiently in a mild condition and at a low catalyst concentration, and a racemic cyanohydrinsilylether compound can be obtained quantificationally, with the activity up to 3000000 turn over number/hour. Characterized by low price and easy availability, mild reaction condition, low catalyst dosage, short reaction time and wide application scope of substrate, the catalyst provided in the invention avoids the disadvantages of severe waterless and anaerobic conditions, high catalyst cost, environmental pollution and the like caused by employment of a metal catalyst, and has strong practicality.

Description

technical field [0001] The invention discloses a high-activity catalyst for synthesizing silicon cyanohydrin silicon ether compounds through the silicocyanation reaction of aldehydes and trimethylsilyl cyanide, belonging to the field of organic synthesis. Background technique [0002] Cyanohydrin compounds are an important class of organic synthesis intermediates, and are direct raw materials for the synthesis of α-hydroxy acids, α-hydroxy aldehydes, β-hydroxy amines, etc. Therefore, the preparation of cyanohydrins has attracted widespread attention, and the addition reaction of carbonyl compounds with trimethylsilyl cyanide (TMSCN) is one of the most effective methods for the synthesis of cyanohydrins. [0003] At present, there are many reports on the preparation of cyanohydrin silicon ethers by the silicocyanation reaction of carbonyl compounds at home and abroad. The commonly used catalysts mainly include Lewis acids, Lewis bases, and inorganic salts. Oxazoline and a ch...

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Problems solved by technology

[0005] The above-mentioned catalysts generally have disadvantages such as a large amount of catalyst used, the use of organic solvents in the reaction, or harsh reaction conditions, which do not meet the requirements of "green chemistry"

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