Compound medicinal composition for reducing blood pressure, and compound tablet for reducing blood pressure

Abstract

The invention discloses a compound medicinal composition for reducing blood pressure and a compound tablet for reducing blood pressure. The compound medicinal composition for reducing blood pressure comprises levamlodipine or pharmaceutically acceptable salt thereof and indapamide, wherein the weight ratio of indapamide to levamlodipine is 1:(1.5-12). The novel compound preparation for reducing blood pressure improves the effect of reducing blood pressure by using synergism among medicines, has a stable effect of reducing blood pressure and excellent cost performance, reduces a side effect, and can be widely popularized and applied to crowds. The compound tablet for reducing blood pressure has high stability and can effectively prolong a validity period.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a compound antihypertensive pharmaceutical composition and a compound antihypertensive tablet. Background technique [0002] In recent years, with the improvement of living standards, the change of dietary structure, and the increase of life pressure, the incidence of hypertension in our country has a tendency to gradually increase. Hypertension is currently a cardiovascular disease with a relatively high incidence rate. It is also the main factor leading to coronary heart disease, stroke, and congestive heart failure. The morbidity and mortality rate rank first in the world. Hypertension is a complex disease with complex etiology and pathogenesis, which often affects the structure and function of various tissues and organs. At the same time, most patients are accompanied by complications of heart, brain, kidney, blood vessel and other diseases. According to data studies, the incidence r...

AI Technical Summary

Problems solved by technology

[0003] For a long time, the stepwise treatment and sequential treatment strategies used in drug treatment of hypertension are based on single drug therapy. The advantages of single drug therapy are simplicity and low cost. But there are also many disadvantages:

[0004](1) Generally, a single drug can only control blood pressure of 40%-60%, or even fewer patients, and the effect on severe hypertension is even worse;

[0005](2) The dose-response curve of commonly used drugs is low and flat, and the effect is not good. When the dose is increased, the curative effect does not increase much, but the side effects can increase logarithmically;

[0007](4) Patients with coexisting diseases or risk factors are often difficult to take into account, thus limiting the use of adequate doses

[0009]However, not all drugs used for prevention and treatment can be used in combination, and random combination of drugs without doctor’s advice will result in half the result with twice the effort in mild cases, and cause adverse consequences in severe cases, even fatal

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