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Application of nano-selenium in antineoplastic drug carrier

An anti-tumor drug and nano-selenium technology, which is applied in the direction of anti-tumor drugs, drug combinations, medical preparations of non-active ingredients, etc., can solve the problems of uneven distribution of doxorubicin and limit the curative effect of doxorubicin, so as to avoid adverse effects effect, reduce toxic and side effects, reduce the effect of toxic effects

Inactive Publication Date: 2012-01-25
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, P-glycoprotein efflux, cardiotoxicity, nephrotoxicity, myelosuppression, and isomerase restriction lead to uneven distribution of doxorubicin and limit the efficacy of doxorubicin

Method used

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  • Application of nano-selenium in antineoplastic drug carrier
  • Application of nano-selenium in antineoplastic drug carrier
  • Application of nano-selenium in antineoplastic drug carrier

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Example 1 Preparation of anti-tumor drug functionalized nano-selenium particles

[0035] At normal temperature and pressure (15 ~ 35 o C, 1 standard atmosphere), prepare 5 mmol L -1 of selenium dioxide or sodium selenite and 20 mmol·L -1 Vitamin C and other reducing solutions. Prepare 32.5 mg·mL -1 5-fluorouracil solution. Take an appropriate amount of antineoplastic drug solution, and then add it at a concentration of 25 mmol L -1 1.0 ml of reductive solution such as vitamin C, shake gently to make it fully mixed, then add dropwise at a concentration of 5 mmol·L -1 1.0 ml of sodium selenite solution, shake gently while adding dropwise, after the dropwise addition, add water to make up to 5 ml volumetric flask. Or stored in powder form, the reaction time is 24 hours. That is, the concentration of nano-selenium is 1 mmol L -1 , the concentration of vitamin C was 4 mmol·L -1 .

Embodiment 2

[0036] Example 2 Preparation of anti-tumor drug functionalized nano-selenium particles

[0037] At normal temperature and pressure (15 ~ 35 o C, 1 standard atmosphere), prepare 5 mmol L -1 of selenium dioxide or sodium selenite and 20 mmol·L -1 Vitamin C and other reducing solutions. Prepare 32.5 mg·mL -1 5-fluorouracil solution. Take the concentration as 20 mmol·L -1 1.0 ml of reducing solution such as vitamin C, the dropwise concentration is 5 mmol·L -1 1.0 ml of sodium selenite solution, shake gently while adding dropwise, add appropriate amount of antineoplastic drug solution, then add and shake gently to make it fully mixed, after the addition is complete, add water to the volumetric flask of 5 ml , when the red color no longer deepened, the product was transferred to an aqueous solution at 4°C and stored in the form of sol or powder, and the reaction time was 24 hours. That is, the concentration of nano-selenium is 1 mmol L -1 , the concentration of vitamin C w...

Embodiment 3

[0038] Example 3 Preparation of 5-fluorouracil functionalized nano-selenium particles

[0039] At normal temperature and pressure (15 ~ 35 o C, 1 standard atmosphere), prepare 5 mmol L -1 of sodium selenite and 20 mmol·L -1 Vitamin C solution 10 ml each. Prepare 32.5 mg·mL -1 5-fluorouracil solution. Then add the concentration of 20 mmol·L -1 1.0 ml of vitamin C solution, shake gently to make it fully mixed, then add dropwise to a concentration of 5 mmol·L -1 1.0 ml of sodium selenite solution, shake gently while adding dropwise, after the dropwise addition, add water to make up to 5 ml volumetric flask. Or stored in powder form, the reaction time is 24 hours. That is, the concentration of nano-selenium is 1 mmol L -1 , the concentration of vitamin C was 4 mmol·L -1 , the concentration of 5-fluorouracil is 6.5 mg·mL -1 product of. The morphology of nano-selenium and 5-fluorouracil functionalized nano-selenium characterized by TECNAI-10 transmission electron micr...

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Abstract

The invention discloses application of nano-selenium in an antineoplastic drug carrier. The nano-selenium is used as a carrier and is used for loading an antineoplastic drug to obtain an antineoplastic drug compound system. The nano-selenium is applied to the antineoplastic drug compound system, so that the prepared antineoplastic drug compound system can bring the synergistic action of an antineoplastic drug and the nano-selenium in resisting tumors into play, and while the penetrability of the antineoplastic drug is enhanced, the toxic or side effect of the antineoplastic drug to human body normal tissues is also reduced. The antineoplastic drug compound system can be preserved in the form of hydrosol in a liquid phase, the preparation process is simple, the condition is mild, the stability is high, and the preservation time is long, so that the antineoplastic drug compound system is suitable for popularization and application.

Description

technical field [0001] The invention relates to the field of antitumor drug carriers, in particular to the application of nanometer selenium in antitumor drug carriers. Background technique [0002] Since cancer is one of the deadliest diseases, 10 million people die from cancer every year. Although diagnostic equipment and treatment techniques have been greatly improved in recent years, and the mortality rate has declined, cancer treatment drugs are generally toxic and lethal to benign human tissues and cells, which needs to be improved urgently (Dan Peer and Jeffrey M. Karp, Nat. Nanotechnol., 2007, 2: 751-760.). The development of nanotechnology seems to have brought light to the heart, and is now applied in engineering, physics, chemistry and biology (Mauro Ferrari , Nat. Rev. Cancer, 2005, 5:161–171.), due to its high specific surface area, small size, and high activity, nanoparticles can overcome the difficulties of cancer treatment and have also been studied as...

Claims

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Application Information

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IPC IPC(8): A61K47/48A61K47/02A61K33/04A61P35/00
Inventor 陈填烽郑文杰刘雯
Owner JINAN UNIVERSITY
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