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Surface modifying method for improving antibacterial property and biological activity of medicinal titanium

A bioactive and surface modification technology, applied in the direction of metal material coating process, coating, solid diffusion coating, etc., can solve the problems of poor antibacterial and biological activity, and achieve the effect of no toxic effect.

Inactive Publication Date: 2012-01-25
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to solve the problem of poor antibacterial properties and biological activity of medical titanium metal in the prior art, the present invention provides a surface modification method for improving the antibacterial properties and biological activity of medical titanium metal, so as to meet the requirements of implanting titanium metal materials. Required antimicrobial and biological activity requirements

Method used

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  • Surface modifying method for improving antibacterial property and biological activity of medicinal titanium
  • Surface modifying method for improving antibacterial property and biological activity of medicinal titanium
  • Surface modifying method for improving antibacterial property and biological activity of medicinal titanium

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] A pure titanium metal sheet of 10mm×10mm×1mm was treated with 5wt% oxalic acid at 100°C for 2 hours, cleaned ultrasonically with deionized water, and dried naturally.

[0033] Put the pure titanium metal sheet pretreated by oxalic acid into the autoclave, pour hydrogen peroxide with a mass fraction of 30% into the autoclave, add 5ml of hydrogen peroxide to each pure titanium metal sheet, and treat at 80°C 6h.

[0034] The samples after hydrothermal treatment for 6 h were taken out and dried naturally. Using plasma immersion ion implantation technology, silver is implanted into the titanium metal substrate after hydrothermal treatment. The specific process parameters are shown in Table 1:

[0035] Table 1 Silver ion implantation parameters

[0036] Injection voltage (kV)

15

Pulse width (μs)

450

Injection time (h)

0.5h

Background vacuum (Pa)

3.6×10 -3

Negative high voltage current (mA)

2.2

Frequency (Hz) ...

Embodiment 2

[0040] A pure titanium metal sheet of 10mm×10mm×1mm was treated with 5wt% oxalic acid at 100°C for 2 hours, cleaned ultrasonically with deionized water, and dried naturally.

[0041] Put the pure titanium metal sheet pretreated by oxalic acid into the autoclave, pour hydrogen peroxide with a mass fraction of 30% into the autoclave, add 5ml of hydrogen peroxide to each pure titanium metal sheet, and treat at 80°C 24h.

[0042] The samples after hydrothermal treatment for 24 h were taken out and dried naturally. Using plasma immersion ion implantation technology, silver is implanted into the titanium metal substrate after hydrothermal treatment. The specific process parameters are shown in Table 2:

[0043] Table 2 Silver ion implantation parameters

[0044] Injection voltage (kV)

15

Pulse width (μs)

450

Injection time (h)

1h

Background vacuum (Pa)

3.6×10 -3

Negative high voltage current (mA)

2.2

Frequency (Hz) ...

Embodiment 3

[0048] A pure titanium metal sheet of 10mm×10mm×1mm was treated with 5wt% oxalic acid at 100°C for 2 hours, cleaned ultrasonically with deionized water, and dried naturally.

[0049] Put the pure titanium metal sheet pretreated by oxalic acid into the autoclave, pour hydrogen peroxide with a mass fraction of 30% into the autoclave, add 5ml of hydrogen peroxide to each pure titanium metal sheet, and treat at 80°C 72h.

[0050] Take out the sample after hydrothermal treatment for 72h, and let it dry naturally. Using plasma immersion ion implantation technology, silver is implanted into the titanium metal substrate after hydrothermal treatment. The specific process parameters are shown in Table 3:

[0051] Table 3 Silver ion implantation parameters

[0052] Injection voltage (kV)

15

Pulse width (μs)

450

Injection time (h)

1h

Background vacuum (Pa)

3.6×10 -3

Negative high voltage current (mA)

2.2

Frequency (Hz)

...

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Abstract

The invention discloses a surface modifying method for improving the antibacterial property and the biological activity of medicinal titanium, which comprises the following steps of: feeding the titanium in hydrogen peroxide and carrying out hydro-thermal treatment at the temperature of 70-90DEG C; and injecting silver ions on the surface of the titanium subjected to the hydro-thermal treatment by using a plasma immersion ion injection technology (PIII). The surface of the titanium subjected to the modification treatment is covered by nanometer titanium dioxide with different morphologies; and after silver is injected, silver nano-particles which have particle size of about 10nm and exist in an elemental form are distributed on the surface of the titanium dioxide. A nanometer titanium dioxide layer can endow the titanium with osteogenic potential; and due to the existence of the silver nano-particles, the antimicrobial activity of the titanium can be remarkably improved. Therefore, the titanium subjected to modification treatment in the invention is a novel implant material with biological activity and antibacterial property, has no toxic action on cells as well as has practical value.

Description

technical field [0001] The present invention relates to a method for surface modification of titanium metal, in particular, relates to a method for surface modification of medical titanium metal by combining chemical method (hydrothermal method) and physical method (plasma immersion ion implantation technology), The invention relates to endowing medical titanium metal materials with good biological activity and antibacterial properties, and belongs to the technical field of surface modification of metal materials. Background technique [0002] Titanium metal is widely used as an implant material because of its good mechanical properties and biocompatibility. However, titanium metal is a biologically inert material. After being implanted into the human body, it is rejected as a foreign body and easily induces inflammation. In addition, bacteria in the surrounding environment may be brought in during the implantation process, thereby causing postoperative infections such as os...

Claims

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Application Information

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IPC IPC(8): C23C8/16C23C10/00
Inventor 刘宣勇李晋波
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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