Composite microspheres of nano liposome capable of being automatically assembled into insoluble medicament in situ and preparation method for composite microspheres

Abstract

The invention discloses composite microspheres of nano liposome capable of being automatically assembled into an insoluble medicament in situ and a preparation method for the composite microspheres. The composite microspheres are compounded by using hydrophilic polymer, soybean lecithin and insoluble medicament in a mass ratio of (15-35): (0.5-5): (0.1-1). The preparation method for the composite microspheres comprises the following steps of: dissolving the hydrophilic polymer, the insoluble medicament and the soybean lecithin by using a co-solvent to form a co-dissolved solution, spraying the co-dissolved solution to a powder receiving plate in a horizontal distance of 15 to 30 centimeters far away from a spraying port of a high-pressure electrostatic spraying device by adopting the high-pressure electrostatic spraying device, and thus obtaining the composite microspheres. The obtained composite microspheres improve the dissolution and dispersion performance of the water-insoluble medicament and the absorption performance of a permeable membrane. In addition, the composite microspheres are prepared by a single step without heating or shearing, and the preparation method is suitable for industrialized production.

Description

technical field [0001] The invention belongs to the field of self-assembled drug-loaded nanoparticles and the preparation thereof, in particular to a composite microsphere capable of in-situ self-assembly into nano liposomes of insoluble drugs and a preparation method thereof. Background technique [0002] Self-assembly is a common phenomenon in life systems and is one of the most essential contents of life. The self-assembly process involves the organization of various material levels from molecules to planets and various interactions between them. At the end of the last century, during the development of supramolecular chemistry, one of the most cutting-edge chemical fields, scientists clearly proposed the concept of self-assembly. It is generally believed that the self-assembly process is a process in which atoms, molecules, particles, and other basic units are spontaneously assembled to form functional structures driven by system energy. Self-assembly also means that ...

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Problems solved by technology

[0009] Based on electrospray, combined with the composite application of materials with different properties, if a new type of self-assembled functional material can be prepared, then due to the wide applicability of the electrospray process, this method will make it possible to construct more and more extensive nanometer self-assembled materials. Opening up a new situation, the applicant has not seen any relevant reports at home and abroad

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