Composite microspheres of nano liposome capable of being automatically assembled into insoluble medicament in situ and preparation method for composite microspheres

A technology for nano-liposomes and insoluble drugs, which is applied in the directions of liposome delivery, medical preparations of inactive ingredients, pharmaceutical formulations, etc., to achieve the effects of simple preparation process, improved dissolution and dispersion performance, and good reproducibility
CN102335142AInactive Publication Date: 2012-02-01UNIV OF SHANGHAI FOR SCI & TECH
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Patent Information

Authority / Receiving Office
CN ยท China
Patent Type
Applications(China)
Current Assignee / Owner
UNIV OF SHANGHAI FOR SCI & TECH
Publication Date
2012-02-01
Estimated Expiration
Not applicable ยท inactive patent

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Abstract

The invention discloses composite microspheres of nano liposome capable of being automatically assembled into an insoluble medicament in situ and a preparation method for the composite microspheres. The composite microspheres are compounded by using hydrophilic polymer, soybean lecithin and insoluble medicament in a mass ratio of (15-35): (0.5-5): (0.1-1). The preparation method for the composite microspheres comprises the following steps of: dissolving the hydrophilic polymer, the insoluble medicament and the soybean lecithin by using a co-solvent to form a co-dissolved solution, spraying the co-dissolved solution to a powder receiving plate in a horizontal distance of 15 to 30 centimeters far away from a spraying port of a high-pressure electrostatic spraying device by adopting the high-pressure electrostatic spraying device, and thus obtaining the composite microspheres. The obtained composite microspheres improve the dissolution and dispersion performance of the water-insoluble medicament and the absorption performance of a permeable membrane. In addition, the composite microspheres are prepared by a single step without heating or shearing, and the preparation method is suitable for industrialized production.
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Description

technical field

[0001] The invention belongs to the field of self-assembled drug-loaded nanoparticles and the preparation thereof, in particular to a composite microsphere capable of in-situ self-assembly into nano liposomes of insoluble drugs and a preparation method thereof. Background technique

[0002] Self-assembly is a common phenomenon in life systems and is one of the most essential contents of life. The self-assembly process involves the organization of various material levels from molecules to planets and various interactions between them. At the end of the last century, during the development of supramolecular chemistry, one of the most cutting-edge chemical fields, scientists clearly proposed the concept of self-assembly. It is generally believed that the self-assembly process is a process in which atoms, molecules, particles, and other basic units are spontaneously assembled to form functional structures driven by system energy. Self-assembly also means that ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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