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External preparation containing analgesic/Anti-inflammatory agent

A topical, anti-inflammatory technology, applied in the direction of anti-inflammatory agents, medical preparations containing active ingredients, medical preparations without active ingredients, etc., to achieve the effects of excellent stability, improved skin permeability, and excellent aesthetics

Inactive Publication Date: 2012-02-01
KOWA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, there is no specific description or suggestion in any of the documents regarding the improvement of the transdermal absorbability of amfenac or its salt and the improvement of the stability of amfenac or its salt in external preparations by the combined use of organic amines.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0096] Embodiment 1 patch

[0097] In 100.0 g of ethyl acetate, 30.0 g of styrene-isoprene-styrene block copolymer (SIS5505P, JSR Co., Ltd.), 24.0 g of terpene resin (YS resin PX1150N, Yasuhara Chemical Co., Ltd. ), 20.0 g of polybutene (polybutene 3SH, NOF Corporation) and 10.5 g of light liquid paraffin (HICALL M72: Kaneda Corporation) to obtain a binder phase.

[0098] Add 1.0 g of amfenac sodium to 5.0 g of polyoxyethylene (2) lauryl ether (NIKKOL BL-2, Nihon Surfactant Kogyo K.K), and after confirming the dissolution, add 0.5 g of diisopropanolamine (diisopropyl Alcoholamine, Mitsui Fine Chemical Inc.), 5.0g oleyl alcohol (NOVOL J, Croda Japan K.K) and 4.0g l-menthol (l-menthol (menthol), Suzuki Mentha (strain)), add the previously prepared Adhesive phase, fully mixed to obtain liquid medicine.

[0099] Spread the drug solution on a silicone-treated PET film by a calcined plaster manufacturing device, and laminate it with a support (woven fabric: TV-105, Japan Vilene Co...

Embodiment 2

[0100] Embodiment 2 patch

[0101] Except for changing light liquid paraffin to 10.0 g and diisopropanolamine to 1.0 g, it was carried out in the same manner as in Example 1 to obtain a patch containing 1% by mass of amfenac sodium.

Embodiment 3

[0102] Embodiment 3 patches

[0103] Except for changing light liquid paraffin to 9.5 g and diisopropanolamine to 1.5 g, it was performed in the same manner as in Example 1 to obtain a patch containing 1% by mass of amfenac sodium.

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PUM

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Abstract

Disclosed is an external preparation which contains the following components (A) and (B). (A) a nonsteroidal analgesic / anti-inflammatory agent (B) an organic amine The external preparation has improved skin permeation, and the nonsteroidal analgesic / anti-inflammatory agent contained in the external preparation has excellent stability. In addition, the external preparation has excellent appearance.

Description

technical field [0001] The present invention relates to external preparations containing nonsteroidal analgesic-anti-inflammatory agents. Background technique [0002] Amfenac or its salt, a non-steroidal anti-inflammatory analgesic of phenylacetic acid, is used for chronic rheumatoid arthritis, osteoarthritis, low back pain, frozen shoulder, neck, shoulder and wrist syndrome, temporomandibular joint disease and after surgery , After trauma, after tooth extraction, etc., anti-inflammatory-analgesic as a function-effect, a capsule containing 50 mg of amfenac sodium in 1 capsule was used. However, amfenac or a salt thereof must be administered orally four times a day because of its short blood half-life. In addition, since amfenac or a salt thereof inhibits the biosynthesis of prostaglandins, it may cause damage to the gastrointestinal mucosa as a side effect (Non-Patent Document 1). [0003] In order to solve such a problem, amfenac or a salt thereof has been demanded as an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61K9/06A61K9/08A61K9/12A61K9/70A61K31/196A61K47/06A61K47/08A61K47/10A61K47/18A61K47/34A61P29/00
CPCA61K9/7053A61K31/16A61K31/196A61K45/06A61P29/00A61K2300/00A61K9/08A61K9/06A61K9/70
Inventor 三浦诚司粟村努山崎裕洋藤井裕也
Owner KOWA CO LTD