Application of pine bark extract to preparation of medicament for treating liver injury

A pine bark extract, liver damage technology, applied in the field of pharmacy, can solve the problems of lagging development of natural liver protection products, uneven liver protection products, and ineffective liver protection effects

Inactive Publication Date: 2012-03-14
上海市第二中学
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, liver protection products are uneven, and the effect of liver protection is not obvious, and the development of natural liver protection products is relatively lagging behind

Method used

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  • Application of pine bark extract to preparation of medicament for treating liver injury
  • Application of pine bark extract to preparation of medicament for treating liver injury
  • Application of pine bark extract to preparation of medicament for treating liver injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Example 1 The test method used in the present invention is: ethanol induces liver damage in mice, establishes an acute ethanol poisoning model, observes the changes in the body and liver tissue of the mice after feeding the pine bark extract, and simultaneously measures the MDA content and SOD activity in the liver tissue Changes, whether there are differences compared with the normal control group and the model group.

[0013] 1. Materials:

[0014] 1.1 Drugs and reagents

[0015] Pine bark extract (water-soluble extract) (Juchen Bioengineering Research Institute), 56-degree Erguotou liquor (diluted with distilled water when used, prepared to a 35% volume ratio concentration), MDA, SOD assay kit (Nanjing Jiancheng Bioengineering Research Institute) So), 0.86% NaCL, 0.9% NaCL

[0016] 1.2 Instruments

[0017] 721 spectrophotometer, TGL-16C high-speed centrifuge, TDL-4 low-speed centrifuge, electric heating constant temperature water temperature box, electronic balanc...

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PUM

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Abstract

The invention belongs to the field of pharmacy, provides application of pine bark extract to preparation of a medicament for treating liver injury, and solves the technical problem of poor effect of the medicament in treatment of a liver injury disease in the prior art. The weight percentage of proanthocyanidin in the pine bark extract is 90-99 percent. The pine bark extract is a polyphenol type substance; and a main active ingredient is low molecular polymer of the proanthocyanidin. Pathological changes of mice organism and liver tissues reflect that the liver injury can be reduced by the pine bark extract, wherein MDA (Methylene Dioxyamphetamine) content of the injured liver tissues can be obviously reduced by 75-150mg / kg pine bark extract, meanwhile, SOD (Superoxide Dismutase) activity is improved; and this fully shows that the pine bark extract has a protection effect on the liver.

Description

technical field [0001] The invention belongs to the field of pharmacy, and in particular relates to a new application of medicine, specifically, the application of pine bark extract in the preparation of medicine for treating liver damage. Background technique [0002] In modern society, people cannot communicate without wine. Although it is said that "no wine can't make a feast", it is undeniable that wine is also "intestinal poison". A statistical data from the Institute of Mental Health of Peking University shows that the number of alcohol drinkers in my country has been on the rise in recent years. At present, the drinking rates of men and women are 84.1% and 29.3% respectively. In recent years, the number of adolescents who drink alcohol has increased. Some research reports noted that approximately 27 percent of adolescents are abusing alcohol. In my country, the incidence of alcoholic liver disease due to alcohol consumption is on the rise, and it has become a hidden k...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/15A61P1/16A61K129/00
Inventor 张岳梅孙玮
Owner 上海市第二中学
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