Mistletoe extract, its preparation method and its application

A technology of mulberry parasites and extracts, applied in the field of biochemistry, can solve the problems of high toxicity and side effects, not suitable for long-term use, etc., and achieve the effect of high safety and uric acid reduction

Inactive Publication Date: 2012-03-14
温尧林 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Western medicine mainly treats hyperuricemia and gout with drugs that prevent purine synthesis (such as allopurinol)

Method used

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  • Mistletoe extract, its preparation method and its application
  • Mistletoe extract, its preparation method and its application
  • Mistletoe extract, its preparation method and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Put 10 kg of mulberry medicinal materials into the reflux extraction tank, and extract with 80L pure water for 1.5 hours; filter, filter the residue with 40L pure water for reflux extraction for 1 hour, filter, combine the two extracts, concentrate to 10L, filter, and absorb the filtrate In D101 resin, remove impurities by eluting with 10% ethanol of 5 times the column volume, then elute with 50% ethanol of 5 times the column volume, concentrate the eluate, and dry to obtain 350 g of total flavonoids of Sangjishen, with a total flavonoid content of 58 % (calculated as storage glycosides, quercetin and quercetin).

Embodiment 2

[0030] Put 10 kg of mulberry medicinal materials into a reflux extraction tank, reflux extraction with 80L of 40% ethanol for 1.5 hours; filter, filter the residue with 40L of 40% ethanol for reflux extraction for 1 hour, filter, combine the two extracts, concentrate and recover ethanol, add water After diluting to 10L, filter, apply polyamide adsorption resin to the filtrate, remove impurities by eluting with 10% ethanol of 5 times the column volume, and then elute with 60% ethanol of 5 times the column volume, concentrate the eluent, and dry to obtain Sangjizi The total flavonoids are 310g, and the total content of flavonoids reaches 63% (calculated by glucoside, quercetin and quercetin).

Embodiment 3

[0032] Put 10 kilograms of mulberry medicinal materials into a reflux extraction tank, and extract with 80 L of 80% ethanol for 1.5 hours under reflux; filter, and then filter the residue with 40 L of 80% ethanol for reflux extraction for 1 hour, filter, combine the two extracts, concentrate and recover ethanol, After diluting the concentrated solution with 3 times the amount of water, add 1 / 2 amount of petroleum ether with a boiling range of 60-90°C to degrease 3 times, extract the water layer with 1 / 2 amount of ethyl acetate three times, combine the extracts, concentrate, and dry to obtain The total flavonoids of Mulberry mulberry is 380g, and the total content of flavonoids can reach 55% (calculated by glucoside, quercetin and quercetin).

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Abstract

The invention belongs to the plant pharmaceutical chemistry field, and provides a mistletoe extract. The mistletoe extract takes dry stems and leaves of mistletoe as a raw material, and is obtained by extraction and purification. In the mistletoe extract, by weighting three flavonoids of avicularin, quercetin and quercitin, the weight percentage of the flavonoids is greater than 50%. The invention provides a method for preparing the mistletoe extract, and also provides an application of the mistletoe extract for preparing medicines or health foods to prevent or treat hyperuricemia or gout. Animal test results show that the mistletoe total flavonoid has substantial effect for reducing uric acid in the blood of hyperuricemia model animals, the mistletoe extract has high security and can be used for medicines and health foods for preparing, preventing and treating hyperuricemia and gout.

Description

Technical field: [0001] The present invention relates to the field of biochemistry, in particular to flavonoids from mulberry vines, in particular to a mulberry mulberry extract and its preparation method and application. Background technique: [0002] Gout is a metabolic disease caused by long-term purine metabolism disorder and increased blood uric acid; hyperuricemia is an important biochemical basis of gout, and is also a risk factor for many diseases. For example, hyperuricemia can not only induce gouty arthritis, urinary Stone disease, uric acid nephropathy, and elevated blood uric acid levels are closely related to abnormal lipid metabolism, obesity and other diseases. [0003] In the past, this disease was relatively rare in Asians or Orientals, but more common in Europe and the United States. However, since the 1990s, Japan, Taiwan and other regions have developed rapidly, and gout and hyperuricemia have gradually become common diseases. After the 1980s, the preval...

Claims

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Application Information

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IPC IPC(8): A61K36/185A23L1/30A61P19/06A61K127/00A61K135/00
Inventor 温尧林李鹏李坤
Owner 温尧林
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